Announcements Trials
Browse Landscape

Phase

Phase 1/2 2Phase 2 1

Status

Withdrawn 1No longer available 1Completed 1Active not recruiting 1

Sponsor Class

INDUSTRY 3OTHER 1

Study Type

Interventional 3Expanded_access 1

Sponsor

Cancer Type

CNS 8Breast 4

Conditions

Breast Neoplasms 34HER2-positive Breast Cancer 5Neoplasms 4Brain Neoplasms 4Triple Negative Breast Neoplasms 3Stomach Neoplasms 3Neoplasm Metastasis 3Colorectal Neoplasms 3Carcinoma, Non-Small-Cell Lung 3Meningeal Neoplasms 2Uterine Neoplasms 1Uterine Cervical Neoplasms 1Urologic Neoplasms 1Pathologic Complete Response 1Ovarian Neoplasms 1Neoplasms by Site 1Metastatic Breast Cancer With a Isolated Brain Progression 1Hemangiosarcoma 1HER2-positive Metastatic Breast Cancer 1Central Nervous System Diseases 1Breast Diseases 1Biliary Tract Neoplasms 1Anatomic Stage II Breast Cancer AJCC v8 1Anatomic Stage IA Breast Cancer AJCC v8 1

Interventions

Trastuzumab 18Radiosurgery 15Capecitabine 13Lapatinib 11Radiotherapy 9Magnetic Resonance Spectroscopy 9trastuzumab deruxtecan 7Temozolomide 6tucatinib 4pembrolizumab 4paclitaxel-Angiopep-2 conjugate 4eribulin 4Vinorelbine 4Specimen Handling 4Paclitaxel 4Methotrexate 4Cisplatin 4sacituzumab govitecan 3pyrotinib 3abemaciclib 3Radiation 3Fluorodeoxyglucose F18 3pertuzumab 2palbociclib 2neratinib 2durvalumab 2cediranib 2cabazitaxel 2Sodium Chloride 2Observation 2

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Brain Neoplasms × tucatinib × Breast × Clear all
NCT04538742 2025-12-08

DB-07

AstraZeneca

Phase 1/2 Active not recruiting
245 enrolled
BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT02614794 2023-08-14

HER2CLIMB

Seagen Inc.

Phase 2 Completed
612 enrolled 30 charts 1 FDA
BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT04512261 2022-07-01

TOPAZ

Cedars-Sinai Medical Center

Phase 1/2 Withdrawn
BreastCNS

Brain Neoplasms, Breast Neoplasms, Central Nervous System Diseases

NCT03424473 2020-02-25

Expanded Access Use of Tucatinib for HER2+ Metastatic Breast Cancer

Seagen Inc.

No longer available
BreastCNS

Brain Neoplasms, Breast Diseases, Breast Neoplasms, Neoplasms, Neoplasms by Site

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