Clinical Trials

Phase 2 Active not recruiting

Brain Neoplasms, Breast Neoplasms, Meningeal Neoplasms

NCT06048718 2026-03-10

TUXEDO-4

28 enrolled

Phase 2 Not yet recruiting

Brain Neoplasms, Breast Neoplasms

NCT07458113 2026-03-09

BERLIN

20 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Triple Negative Breast Neoplasms

NCT07454668 2026-03-06

Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases

20 enrolled

BreastCNSGastrointestinalGenitourinaryHead & NeckThoracic

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT04075305 2026-03-05

MOMENTUM

Recruiting

8,000 enrolled

Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Genital Neoplasms, Female, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Radiation Injuries, Rectal Neoplasms

NCT06315296 2026-03-03

An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer

Phase NA Terminated

1 enrolled

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms

NCT05376878 2026-02-23

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

Phase 4 Recruiting

10 enrolled

Brain Neoplasms, Breast Neoplasms

NCT04348747 2026-02-12

Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

Phase 2 Recruiting

23 enrolled

Brain Neoplasms, Triple Negative Breast Neoplasms

NCT05556473 2026-01-23

F-Tryptophan PET/CT in Human Cancers

BreastCNSEndocrineGastrointestinalNET

24 enrolled

Brain Neoplasms, Breast Neoplasms, Rectal Neoplasms, Neuroendocrine Tumors

NCT04711824 2025-12-23

SOLARA

Phase 1/2 Recruiting

41 enrolled

Phase 2 Active not recruiting

Brain Neoplasms, Breast Neoplasms

NCT05305365 2025-12-23

Study Assessing QBS72S For Treating Brain Metastases

21 enrolled

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms, Meningeal Neoplasms

NCT06247449 2025-12-18

MRI Screening for Brain Metastases Among Patients With Triple Negative or HER2+ Stage II or III Breast Cancer

Phase NA Recruiting

100 enrolled

Brain Neoplasms, Breast Neoplasms

NCT04965064 2025-12-15

Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling

Phase 2 Recruiting

22 enrolled

BreastCNSGastrointestinalSarcoma

Brain Neoplasms, Breast Neoplasms

NCT03823144 2025-12-11

Intravital Microscopy in Human Solid Tumors

Phase NA Recruiting

85 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Hepatocellular, Pancreatic Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT03807765 2025-12-04

Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases

Phase 1 Completed

14 enrolled

Brain Neoplasms, Breast Neoplasms

NCT07251868 2025-11-26

Evaluation of Trop-2 ADC in Breast Cancer Patients With Brain Metastases: A Real-World Study

Recruiting

100 enrolled

Brain Neoplasms, Breast Neoplasms

NCT06072807 2025-11-24

Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer

Phase 4 Recruiting

20 enrolled

Brain Neoplasms, Breast Neoplasms

NCT06171945 2025-10-27

AYAConnect

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOtherOther hematologic neoplasmSarcoma

63 enrolled

Psychological Well-Being, Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Hodgkin Disease, Kidney Neoplasms, Leukemia, Liver Neoplasms, Lymphoma, Non-Hodgkin, Melanoma, Motor Activity, Mouth Neoplasms, Neoplasms, Obesity, Pancreatic Neoplasms, Pharyngeal Neoplasms, Rectal Neoplasms, Sarcoma, Testicular Neoplasms, Thyroid Neoplasms, Weight Loss, Endometrial Neoplasms, Overweight

NCT06180460 2025-10-08

CALM: Managing Distress in Malignant Brain Cancer

BreastCNSDermatologicGastrointestinalGenitourinaryThoracic

60 enrolled

Brain Neoplasms, Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Lung Neoplasms, Melanoma

NCT06199050 2025-10-02

ENGAGE

BreastCNSGenitourinaryHead & NeckThoracic

292 enrolled

Anxiety Disorders, Brain Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Prostatic Neoplasms

NCT07177950 2025-09-17

A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases

Phase 1/2 Not yet recruiting

51 enrolled

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT06504719 2025-09-15

Safety and Efficacy Real-world Data of Trastuzumab Deruxtecan and Sacituzumab Govitecan

Completed

312 enrolled

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis

NCT06582849 2025-08-26

EARN

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmSarcomaThoracic

33 enrolled

Anus Neoplasms, Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms

NCT07118176 2025-08-12

Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers

BreastCNSEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETSarcomaThoracic

30 enrolled

Adrenal Gland Neoplasms, Anus Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Colorectal Neoplasms, Carcinoma, Medullary, Cholangiocarcinoma, Neuroendocrine Tumors, Solitary Fibrous Tumors

NCT04420598 2025-06-24

DEBBRAH

Phase 2 Completed

41 enrolled 32 charts

BreastCNSDermatologicGastrointestinalGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Meningeal Carcinomatosis

NCT04588246 2025-06-06

Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

Phase 3 Terminated

19 enrolled 19 charts

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Small Cell Lung Carcinoma

NCT06494046 2025-06-04

Defining Musical Toxicity and Its Effect on Patient Well-being

Withdrawn

BreastCNSGastrointestinalThoracic

Brain Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Lung Neoplasms

NCT06673329 2025-05-14

Brodalumab in the Treatment of Immune-Related Adverse Events

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

11 enrolled

Brain Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms

NCT00838929 2025-05-04

Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases

Phase 1 Completed

17 enrolled 8 charts

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms

NCT03696030 2025-04-13

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

Phase 1 Active not recruiting

24 enrolled

BreastCNSDermatologicGastrointestinalHead & NeckOther hematologic neoplasmThoracic

Brain Neoplasms, Breast Neoplasms, Neoplasms, Meningeal Carcinomatosis

NCT06168825 2025-02-27

MOM

Completed

40 enrolled

Brain Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Urogenital Neoplasms, Colorectal Neoplasms, Central Nervous System Neoplasms, Hematologic Neoplasms

NCT05131815 2025-02-26

The BurnAlong Pilot Study for Adolescent and Young Adult Cancer Survivors

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckLymphoidOther hematologic neoplasmPlasma cellSarcomaThoracic

8 enrolled

Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Gastrointestinal Neoplasms, Glioblastoma, Head and Neck Neoplasms, Hodgkin Disease, Leukemia, Lung Neoplasms, Lymphoma, Lymphoma, Non-Hodgkin, Motor Activity, Multiple Myeloma, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Skin Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms

NCT06835426 2025-02-19

High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins

Phase NA Recruiting

150 enrolled

BreastCNSDermatologicGenitourinaryHead & Neck

Brain Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, Parathyroid Neoplasms, Prostatic Neoplasms, Skin Neoplasms, Thyroid Neoplasms, Urogenital Neoplasms

NCT06793332 2025-01-27

BALISTA

Phase 2 Recruiting

39 enrolled

Phase NA Active not recruiting

Brain Neoplasms, Triple Negative Breast Neoplasms

NCT03881605 2025-01-20

SYMPToM

50 enrolled

Phase NA Active not recruiting

Brain Neoplasms, Breast Neoplasms, Triple Negative Breast Neoplasms

NCT03075072 2024-10-23

Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial

196 enrolled

BreastCNSDermatologicGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Kidney Neoplasms, Lung Neoplasms, Melanoma, Recurrence

NCT06611306 2024-10-15

BEAT-Breast

Phase NA Not yet recruiting

42 enrolled

Brain Neoplasms, Breast Neoplasms

NCT05689112 2024-08-21

Microscopy Imaging of Whole-mount Stained Human Tissues

Unknown

250 enrolled

BreastCNSDermatologic

Brain Neoplasms, Breast Neoplasms, Skin Neoplasms

NCT04395339 2024-08-01

GLORY

Phase 3 Terminated

51 enrolled

Brain Neoplasms, Breast Neoplasms, Gangliosidoses, Radiation Injuries, Gangliosidosis, GM1, Cognitive Dysfunction

NCT01706432 2024-07-31

Hypofractionated Image Guided Radiation Therapy in Treating Patients With Stage IV Breast Cancer

Completed

4 enrolled

BreastCNSGastrointestinalGenitourinaryHead & Neck

Breast Carcinoma In Situ, Brain Neoplasms, Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Breast Neoplasms, Male

NCT05184790 2024-07-26

LEARN

Recruiting

300 enrolled

Arrhythmias, Cardiac, Brain Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Spinal Neoplasms

NCT05549024 2024-07-05

68Ga-RM26-RGD PET/CT Imaging in the GRPR and αvβ3 Positive Tumor Patients

Phase EARLY_PHASE1 Recruiting

90 enrolled

BreastCNSGenitourinary

Brain Neoplasms, Breast Neoplasms, Prostatic Neoplasms

NCT04842812 2024-06-25

Engineered TILs/CAR-TILs to Treat Advanced Solid Tumors