Announcements Trials
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Phase

Phase NA 2Phase 2 2Phase 3 1

Status

Recruiting 4Completed 1

Sponsor Class

OTHER 5

Study Type

Interventional 5

Sponsor

Cancer Type

CNS 7Thoracic 5Breast 5

Conditions

Breast Neoplasms 6Meningeal Carcinomatosis 5Lung Neoplasms 4Carcinoma, Non-Small-Cell Lung 3

Interventions

Magnetic Resonance Spectroscopy 6Spinal Puncture 5Specimen Handling 5Methotrexate 3Trastuzumab 2Radiotherapy, Intensity-Modulated 2Radiotherapy 2trastuzumab deruxtecan 1tipifarnib 1sacituzumab govitecan 1paclitaxel-Angiopep-2 conjugate 1merphos 1eribulin 1epothilone B 1Vinorelbine 1Sorafenib 1Referral and Consultation 1Radiation 1Probability 1Physical Examination 1Pemetrexed 1Immunotherapy, Adoptive 1Immunoenzyme Techniques 1Etoposide 1Cytarabine 1Craniospinal Irradiation 1Cisplatin 1Capecitabine 1Bevacizumab 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Meningeal Carcinomatosis × Spinal Puncture × Breast × Clear all
NCT06500481 2026-05-07

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

NRG Oncology

Phase 3 Recruiting
115 enrolled
BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT05746325 2026-04-02

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Mayo Clinic

Phase NA Recruiting
5 enrolled
BreastCNSThoracic

Breast Neoplasms, Lung Neoplasms, Meningeal Carcinomatosis

NCT05286684 2026-03-18

Exo-LCR

Centre Oscar Lambret

Phase NA Completed
7 enrolled
BreastCNS

Breast Neoplasms, Meningeal Carcinomatosis

NCT06518057 2025-12-11

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

University of Washington

Phase 2 Recruiting
22 enrolled
BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT06910761 2025-12-08

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

City of Hope Medical Center

Phase 2 Recruiting
35 enrolled
BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

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