Clinical Trials

Phase 1 Active not recruiting

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT03696030 2026-04-23

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

24 enrolled

Brain Neoplasms, Breast Neoplasms, Neoplasms, Meningeal Carcinomatosis

NCT05746325 2026-04-02

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Phase NA Recruiting

5 enrolled

Breast Neoplasms, Lung Neoplasms, Meningeal Carcinomatosis

NCT05286684 2026-03-18

Exo-LCR

Phase NA Completed

7 enrolled

Breast Neoplasms, Meningeal Carcinomatosis

NCT06518057 2025-12-11

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

Phase 2 Recruiting

22 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT06910761 2025-12-08

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

Phase 2 Recruiting

35 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT01373710 2025-11-24

HIT

Phase 1/2 Completed

34 enrolled

Breast Neoplasms, Meningeal Carcinomatosis

NCT06462092 2025-09-29

Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer

Phase 1/2 Recruiting

34 enrolled

Breast Neoplasms, Meningeal Carcinomatosis

NCT03974204 2025-09-26

Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis.

Phase NA Withdrawn

Phase 1/2 Not yet recruiting

Breast Neoplasms, Meningeal Carcinomatosis

NCT07177950 2025-09-17

A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases

51 enrolled

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT04420598 2025-06-24

DEBBRAH

41 enrolled 32 charts

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Meningeal Carcinomatosis

NCT02948751 2024-06-06

Microfluidic Device to Diagnose Leptomeningeal Metastasis in Breast Cancer

Completed

14 enrolled 7 charts

Breast Neoplasms, Meningeal Carcinomatosis

NCT06137651 2024-04-01

Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Phase 1 Withdrawn

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT03661424 2022-12-20

BATs in Patients With Breast Cancer and Leptomeningeal Metastases

Phase 1 Terminated

3 enrolled

Breast Neoplasms, Meningeal Carcinomatosis

NCT01645839 2019-06-12

DEPOSEIN

Phase 3 Completed

74 enrolled

Breast Neoplasms, Meningeal Carcinomatosis

NCT00992602 2017-07-07

Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer

3 enrolled 8 charts

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT00450866 2014-02-28

Epothilone B in Treating Patients With CNS Metastases From Breast Cancer

55 enrolled 12 charts

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Breast Neoplasms, Male, Meningeal Carcinomatosis

NCT01281696 2013-10-16

Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis

40 enrolled

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT00964743 2013-09-09

Depocyt® With Sorafenib in Neoplastic Meningitis

Phase NA Terminated

2 enrolled 6 charts