Clinical Trials Browser

Brain Diseases × CNS × Clear all

NCT03911388 2026-04-13

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Phase 1 Recruiting

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT05386108 2026-04-06

ELECTRA

Phase 1/2 Recruiting

Brain Diseases, Brain Neoplasms, Breast Diseases, Breast Neoplasms, Central Nervous System Diseases, Neoplasms, Neoplasms by Site, Central Nervous System Neoplasms

NCT05522387 2026-02-27

An Open-Label Extension of XPro1595 in Patients With Alzheimer's Disease

Phase 2 Terminated

Alzheimer Disease, Mental Disorders, Brain Diseases, Central Nervous System Diseases, Dementia, Inflammation, Nervous System Diseases, Neurodegenerative Diseases, Neurocognitive Disorders, Tauopathies

NCT05762419 2026-01-28

FUS Etoposide for DMG

Phase 1 Recruiting

Diffuse Intrinsic Pontine Glioma, Brain Diseases, Brain Neoplasms, Glioma, Nervous System Neoplasms, Central Nervous System Neoplasms

NCT00811148 2026-01-13

FCBTR

Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Nervous System Neoplasms, Central Nervous System Neoplasms

NCT04543188 2025-10-23

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

Phase 1 Terminated

65 enrolled 52 charts

CNSDermatologicThoracic

Brain Diseases, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasms, Central Nervous System Neoplasms

NCT05270707 2025-09-24

HyperArc Registry Study

Brain Diseases, Brain Neoplasms, Central Nervous System Neoplasms

NCT07126821 2025-08-17

A Vision-Language Foundation Model for Brain Disease Diagnosis From Multimodal Data

100,000 enrolled

Brain Diseases, Brain Neoplasms, Disease, Neoplasms, Neurologic Manifestations, Intracranial Arterial Diseases

NCT03593330 2025-05-02

TCP

Phase NA Terminated

Aneurysm, Brain Diseases, Brain Neoplasms, Hydrocephalus, Spinal Cord Neoplasms, Spinal Curvatures, Spinal Diseases, Spinal Stenosis, Trigeminal Neuralgia, Spinal Fractures

NCT05921786 2024-08-21

Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling-Establish Reliably Electrophysiological Readouts From Human-induced Pluripotent Stem Cells (hiPSCs)-Derived Cerebral Organoids and Surgically Dissected Human Live Brains

Phase NA Recruiting

Brain Diseases, Brain Neoplasms

NCT04755920 2024-05-09

SGM-CBM

Phase 2 Recruiting

CNSGastrointestinal

Brain Diseases, Brain Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05321498 2023-09-28

Study to Assess the Efficacy of XPro1595 in Patients With Mild Cognitive Impairment With Biomarkers of Inflammation

Phase 2 Withdrawn

Alzheimer Disease, Mental Disorders, Brain Diseases, Central Nervous System Diseases, Dementia, Inflammation, Nervous System Diseases, Neurodegenerative Diseases, Tauopathies, Cognitive Dysfunction

NCT01290692 2023-07-03

Study To Test the Safety and Efficacy of TVI-Brain-1 As A Treatment for Recurrent Grade IV Glioma

Phase 2 Completed

14 enrolled 11 charts

Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Glioblastoma, Glioma, Neoplasms, Nervous System Diseases, Nervous System Neoplasms, Central Nervous System Neoplasms

NCT01081223 2023-06-01

Phase I/II Study To Test The Safety and Efficacy of TVI-Brain-1 As A Treatment For Recurrent Grade IV Glioma

Phase 1/2 Completed

12 enrolled 11 charts

Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Glioblastoma, Glioma, Neoplasms, Nervous System Diseases, Nervous System Neoplasms, Central Nervous System Neoplasms

NCT03650452 2021-02-18

ELEKTRA

Phase 2 Completed

141 enrolled 24 charts

CDKL5 deficiency disorder, Brain Diseases, Central Nervous System Diseases, Epilepsy, Epilepsies, Myoclonic, Nervous System Diseases, Seizures, Spasms, Infantile, Tuberous Sclerosis, Hypoxia-Ischemia, Brain, Malformations of Cortical Development, Lennox Gastaut Syndrome

NCT00924820 2020-12-31

A Pilot Study of Bevacizumab for Neoplastic Meningitis

Phase 1/2 Completed

20 enrolled 7 charts

Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Meningeal Carcinomatosis

NCT02965144 2020-06-04

Long Term Survivors of High-grade Glioma and Their Caregivers

13 enrolled 8 charts

Brain Diseases, Depression, Glioma

NCT03629964 2020-05-08

Study to Develop Head Stabilizer for Use During Brain Radiation Therapy

Phase NA Withdrawn

Brain Diseases, Brain Neoplasms

NCT03710278 2019-09-18

LPat

Brain Diseases, Brain Neoplasms, Encephalitis, Meningitis, Subarachnoid Hemorrhage, Guillain-Barre Syndrome

NCT00895960 2018-11-08

Dasatinib Plus Radiation Therapy/Temozolomide in Newly-Diagnosed Glioblastoma

Phase 1 Terminated

Brain Diseases, Central Nervous System Diseases, Glioblastoma, Gliosarcoma

NCT00649207 2017-11-21

A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Patients With Brain Metastases

Phase 1 Completed

Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Neoplasm Metastasis, Nervous System Neoplasms

NCT01386580 2015-01-22

An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.

Phase 1/2 Completed

BreastCNSDermatologicThoracic

Brain Diseases, Brain Neoplasms, Breast Neoplasms, Central Nervous System Diseases, Glioma, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Site, Neoplastic Processes, Nervous System Diseases, Nervous System Neoplasms, Pathologic Processes, Central Nervous System Neoplasms

NCT00643890 2012-02-22

Study of AAV-GAD Gene Transfer Into the Subthalamic Nucleus for Parkinson's Disease

Phase 2 Terminated

Basal Ganglia Diseases, Brain Diseases, Central Nervous System Diseases, Movement Disorders, Nervous System Diseases, Parkinson Disease, Neurodegenerative Diseases, Parkinsonian Disorders, Ganglion Cysts

NCT00906516 2009-05-21

Neuradiab® Combined With Bevacizumab (Avastin) Therapy in Patients With Recurrent Glioblastoma Multiforme

Phase 2 Unknown

Brain Diseases, Brain Neoplasms, Glioblastoma