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Phase

Phase 1 1

Status

Active not recruiting 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

Sarcoma 1Other solid neoplasm 1Genitourinary 1Gastrointestinal 1Dermatologic 1CNS 1

Conditions

Glioblastoma 40Brain Neoplasms 34Melanoma 15Glioma 13Carcinoma, Non-Small-Cell Lung 9Gliosarcoma 7Neoplasms 6Carcinoma, Renal Cell 6Stomach Neoplasms 5Ovarian Neoplasms 4Meningioma 4Lung Neoplasms 4Esophageal Neoplasms 4Colorectal Neoplasms 4Breast Neoplasms 4Astrocytoma 4Uterine Cervical Neoplasms 3Triple Negative Breast Neoplasms 3Sarcoma 3Recurrence 3Central Nervous System Neoplasms 3Uveal Melanoma 2Turcot syndrome 2Squamous Cell Carcinoma of Head and Neck 2Small Cell Lung Carcinoma 2Parkinson Disease 4, Autosomal Dominant Lewy Body 2Pancreatic Neoplasms 2Neuroblastoma 2Neoplasms, Germ Cell and Embryonal 2Neoplasm Metastasis 2

Interventions

Thiotepa 3fludarabine phosphate 2Melphalan 2Filgrastim 2thymoglobulin 1tanespimycin 1pembrolizumab 1omburtamab I-131 1fludarabine 1Zoledronic Acid 1Topotecan 1Tacrolimus 1Stem Cell Transplantation 1Peripheral Blood Stem Cell Transplantation 1Mycophenolic Acid 1Mesna 1Immunologic Techniques 1Imatinib Mesylate 1Granulocyte Colony-Stimulating Factor 1Etoposide 1Cytoreduction Surgical Procedures 1Cyclosporins 1Cyclosporine 1Cyclophosphamide 1Cisplatin 1Carboplatin 1CLR1404 1Busulfan 1Bone Marrow Transplantation 1Arsenic Trioxide 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Desmoplastic Small Round Cell Tumor × pembrolizumab × CNS × Clear all
NCT04483778 2026-04-28

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Seattle Children's Hospital

Phase 1 Active not recruiting
68 enrolled
CNSDermatologicGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Carcinoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

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