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Phase

Phase 1 1

Status

Completed 1

Sponsor Class

NIH 1

Study Type

Interventional 1

Sponsor

Cancer Type

Sarcoma 1Gynecologic 1Genitourinary 1Gastrointestinal 1CNS 1

Conditions

Glioblastoma 17Gliosarcoma 15Central Nervous System Neoplasms 14Astrocytoma 13Brain Neoplasms 10Glioma 8Oligodendroglioma 7Optic Nerve Glioma 3Medulloblastoma 3Familial ependymoma 3Choroid Plexus Neoplasms 3Ependymoma 2Wilms Tumor 1Testicular Neoplasms 1Teratoma 1Sarcoma 1Precursor Cell Lymphoblastic Leukemia-Lymphoma 1Ovarian Neoplasms 1Ovarian Germ Cell Cancer 1Osteosarcoma 1Neuroectodermal Tumors, Primitive, Peripheral 1Neuroectodermal Tumors, Primitive 1Neuroblastoma 1Lymphoma, Non-Hodgkin 1Lymphoma, Mantle-Cell 1Lymphoma, Large-Cell, Immunoblastic 1Lymphoma, Large B-Cell, Diffuse 1Lymphoma, Follicular 1Lymphoma, B-Cell, Marginal Zone 1Lymphoma 1

Interventions

Carboplatin 5Filgrastim 4Thiotepa 3Temozolomide 3Radiotherapy 3Cyclophosphamide 3sargramostim 2fludarabine 2aldesleukin 2Peripheral Blood Stem Cell Transplantation 2Melphalan 2Ifosfamide 2Granulocyte Colony-Stimulating Factor 2Etoposide 2Busulfan 2sodium thiosulfate 1pembrolizumab 1ixabepilone 1fludarabine phosphate 1etoposide phosphate 1erythromycin propionate-N-acetylcysteinate 1brodalumab 1Topotecan 1Thrombopoietin 1Tamoxifen 1Stem Cell Transplantation 1Sevoflurane 1Restraint, Physical 1Radiotherapy, Intensity-Modulated 1Quality of Life 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Liver Neoplasms × O(6)-benzylguanine × CNS × Clear all
NCT00020150 2015-04-29

Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors

National Cancer Institute (NCI)

Phase 1 Completed
CNSGastrointestinalGenitourinaryGynecologicSarcoma

Familial ependymoma, Ovarian Germ Cell Cancer, Astrocytoma, Kidney Neoplasms, Liver Neoplasms, Medulloblastoma, Wilms Tumor, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Optic Nerve Glioma

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