Announcements Trials
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Phase

Phase 1/2 2Phase 1 1

Status

Completed 3

Sponsor Class

OTHER 3

Study Type

Interventional 3

Sponsor

Cancer Type

CNS 3

Conditions

Brain Neoplasms 14Glioblastoma 6Neoplasms 4Lymphoma, Non-Hodgkin 4Breast Neoplasms 4Testicular Neoplasms 3Precursor Cell Lymphoblastic Leukemia-Lymphoma 3Neuroblastoma 3Neoplasm Metastasis 3Meningeal Carcinomatosis 3Lymphoma 3Glioma 3Burkitt Lymphoma 3Vomiting 2Testicular Germ Cell Tumor 2Sezary Syndrome 2Recurrence 2Radiation Injuries 2Primary Myelofibrosis 2Pdgfra-Associated Chronic Eosinophilic Leukemia 2Oligodendroglioma 2Nausea 2Myeloproliferative Disorders 2Mycosis Fungoides 2Multiple Myeloma 2Melanoma 2Medulloblastoma 2Lymphoma, T-Cell, Cutaneous 2Lymphoma, Mantle-Cell 2Lymphoma, Large-Cell, Immunoblastic 2

Interventions

Pemetrexed 20Bevacizumab 10Radiotherapy 8Spinal Puncture 7osimertinib 6Methotrexate 6Magnetic Resonance Spectroscopy 6aflutinib 5Topotecan 5Specimen Handling 5Trastuzumab 4Temozolomide 4Radiotherapy, Intensity-Modulated 4Dexamethasone 3trastuzumab deruxtecan 2pembrolizumab 2paclitaxel-Angiopep-2 conjugate 2omburtamab I-131 2merphos 2lorlatinib 2aumolertinib 2WP 744 2Vitamin B 12 2Rituximab 2Radiation 2Folic Acid 2Drug Therapy 2Cytarabine 2Cyclophosphamide 2Capecitabine 2

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
Meningeal Carcinomatosis × Dexamethasone × CNS × Clear all
NCT05289908 2025-05-04

Intrathecal Pemetrexed for Leptomeningeal Metastasis

The First Hospital of Jilin University

Phase 1/2 Completed
34 enrolled
CNS

Meningeal Carcinomatosis

NCT03507244 2019-12-26

Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors

The First Hospital of Jilin University

Phase 1/2 Completed
34 enrolled
CNS

Meningeal Carcinomatosis

NCT03101579 2019-03-19

Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer

The First Hospital of Jilin University

Phase 1 Completed
13 enrolled
CNS

Recurrence, Meningeal Carcinomatosis

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