Clinical Trials Browser

Phase 2 × Meningeal Carcinomatosis × CNS × Clear all

NCT07551414 2026-04-24

Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI

Phase 2 Not yet recruiting

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT06812871 2026-04-02

High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis

Phase 2 Completed

Meningeal Carcinomatosis

NCT05805631 2026-03-24

Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC

Phase 2 Recruiting

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT04343573 2026-02-27

Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors

Phase 2 Completed

Meningeal Carcinomatosis

NCT06058988 2026-02-23

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Phase 2 Recruiting

Brain Neoplasms, Glioblastoma, Neoplasm Metastasis, Meningeal Carcinomatosis

NCT06296745 2026-01-30

Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib.

Phase 2 Recruiting

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT07304739 2025-12-26

Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases

Phase 2 Recruiting

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT06518057 2025-12-11

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

Phase 2 Recruiting

BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT06910761 2025-12-08

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

Phase 2 Recruiting

BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT05800275 2025-11-18

ETIC-LM

Phase 2 Recruiting

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT02939300 2025-11-14

Ipilimumab and Nivolumab in Leptomeningeal Metastases

Phase 2 Completed

18 enrolled 17 charts

Meningeal Carcinomatosis

NCT07193654 2025-09-26

Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced Spread

Phase 2 Recruiting

Glioblastoma, Meningeal Carcinomatosis

NCT04729348 2025-07-25

Pembrolizumab And Lenvatinib In Leptomeningeal Metastases

Phase 2 Terminated

Meningeal Carcinomatosis

NCT04420598 2025-06-24

DEBBRAH

Phase 2 Completed

41 enrolled 32 charts

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Meningeal Carcinomatosis

NCT06971406 2025-05-14

FLAME-1

Phase 2 Not yet recruiting

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT06901817 2025-03-30

A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases

Phase 2 Recruiting

Meningeal Carcinomatosis

NCT06861218 2025-03-06

Cerebrospinal Fluid Cytology-guided Intrathecal Chemo-holiday Therapy for EGFR-positive NSCLC Leptomeningeal Metastases

Phase 2 Not yet recruiting

Meningeal Carcinomatosis

NCT04233021 2025-02-03

ORBITAL

Phase 2 Completed

Brain Neoplasms, Meningeal Carcinomatosis

NCT05146219 2024-12-30

Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation

Phase 2 Completed

Brain Neoplasms, Meningeal Carcinomatosis

NCT06728865 2024-12-11

Better Brain

Phase 2 Recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT00801216 2024-12-10

SCNSL1

Phase 2 Completed

40 enrolled 11 charts

Lymphoma, B-Cell, Meningeal Carcinomatosis

NCT06441045 2024-06-04

Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKI

Phase 2 Not yet recruiting

Meningeal Carcinomatosis

NCT05813522 2023-04-14

Furmonertinib in Patients With Leptomeningeal Metastases Associated With EGFR Mutated NSCLC

Phase 2 Unknown

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT05810350 2023-04-13

Aumolertinib Combined Intrathecal Chemotherapy for Leptomeningeal Metastasis From EGFR-Mutated NSCLC and Prognostic Value of Dynamic Changes in cfDNA Profiles

Phase 2 Unknown

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT05385185 2022-05-23

Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung Cancer

Phase 2 Unknown

Meningeal Carcinomatosis

NCT02616393 2022-03-16

Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases

Phase 2 Completed

36 enrolled 22 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT04833205 2021-04-20

Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer

Phase 2 Unknown

Lung Neoplasms, Meningeal Carcinomatosis

NCT04425681 2020-06-11

OWBLM

Phase 2 Unknown

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT02684071 2020-01-10

Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors

Phase 2 Terminated

Familial ependymoma, Ependymoma, Medulloblastoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor, Meningeal Carcinomatosis

NCT04148898 2019-11-04

OWONBNSCLCLM

Phase 2 Unknown

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT03082144 2019-08-01

Concurrent Involved-field Radiotherapy and Intrathecal Chemotherapy for Leptomeningeal Metastases From Solid Tumors

Phase 2 Completed

Meningeal Carcinomatosis

NCT00992602 2017-07-07

Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer

Phase 2 Completed

3 enrolled 8 charts

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT02654106 2017-06-06

SRTRBM

Phase 2 Completed

Brain Neoplasms, Meningeal Carcinomatosis

NCT00450866 2014-02-28

Epothilone B in Treating Patients With CNS Metastases From Breast Cancer

Phase 2 Completed

55 enrolled 12 charts

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Breast Neoplasms, Male, Meningeal Carcinomatosis

NCT01818713 2013-10-29

Clinical and Pharmacological Study With 2B3-101 in Patients With Breast Cancer and Leptomeningeal Metastases

Phase 2 Unknown

Meningeal Carcinomatosis

NCT01281696 2013-10-16

Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis

Phase 2 Completed

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT00523939 2013-06-17

DepoCyt for Active Lymphomatous or Leukemic Meningitis

Phase 2 Terminated

4 enrolled 6 charts

CNSLymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Lymphoma, B-Cell, Meningeal Carcinomatosis

NCT00005812 2013-05-14

Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma

Phase 2 Terminated

Brain Neoplasms, Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00005811 2013-02-21

Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment

Phase 2 Completed

CNSLymphoidOther hematologic neoplasmSarcoma

Burkitt Lymphoma, Medulloblastoma, Recurrence, Lymphoma, Large B-Cell, Diffuse, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Dendritic Cell Sarcoma, Interdigitating, Meningeal Carcinomatosis

NCT00830245 2011-07-26

A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR Mutation Positive Non-small Cell Lung Cancer

Phase 2 Terminated

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis