Announcements Trials
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Phase

Phase 1/2 1Phase 1 1

Status

Active not recruiting 2

Sponsor Class

OTHER 1NIH 1

Study Type

Interventional 2

Sponsor

Cancer Type

CNS 2Breast 2Thoracic 1

Conditions

Glioblastoma 108Brain Neoplasms 106Glioma 83Neuroblastoma 34Astrocytoma 26Neoplasms 25Medulloblastoma 25Central Nervous System Neoplasms 25Neurofibromatosis 1 23Meningioma 23Ependymoma 22Sarcoma 21Breast Neoplasms 18Rhabdoid Tumor 16Melanoma 16Neurofibroma, Plexiform 15Carcinoma, Non-Small-Cell Lung 15Osteosarcoma 14Wilms Tumor 13Rhabdomyosarcoma 13Thyroid Neoplasms 12Sarcoma, Ewing 12Hepatoblastoma 12Gliosarcoma 12Recurrence 11Diffuse Intrinsic Pontine Glioma 11Pheochromocytoma 10Pancreatic Neoplasms 10Neoplasm Metastasis 10Ovarian Neoplasms 9

Interventions

sapanisertib 1pertuzumab 1Trastuzumab 1Radiotherapy 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Meningeal Neoplasms × CNS × 30 days × Clear all
NCT04250545 2026-05-26

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

National Cancer Institute (NCI)

Phase 1 Active not recruiting
22 enrolled 14 charts
CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Neoplasms

NCT04588545 2026-05-26

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

H. Lee Moffitt Cancer Center and Research Institute

Phase 1/2 Active not recruiting
33 enrolled
CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

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