Clinical Trials

Phase 2 Active not recruiting

Brain Neoplasms, Glioblastoma, Neoplasm Metastasis, Meningeal Carcinomatosis

NCT02721732 2026-01-29

Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic

157 enrolled 26 charts

CNSEndocrineGenitourinary

Adrenal Cortex Neoplasms, Carcinoma, Renal Cell, Neoplasm Metastasis, Neoplasms, Unknown Primary, Paraganglioma, Penile Neoplasms, Pheochromocytoma, Carcinoma, Small Cell, Vascular Neoplasms

NCT05673928 2026-01-21

A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)

Phase 2 Recruiting

30 enrolled

Phase 2 Active not recruiting

Brain Neoplasms, Neoplasm Metastasis

NCT05503251 2025-12-24

Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases

110 enrolled

Phase 2 Active not recruiting

Brain Neoplasms, Neoplasm Metastasis

NCT02374242 2025-12-10

ABC

76 enrolled

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT04420598 2025-06-24

DEBBRAH

41 enrolled 32 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Meningeal Carcinomatosis

NCT03898908 2025-05-21

EBRAIN-MEL

48 enrolled 24 charts

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT00843037 2024-10-17

SNIPP

25 enrolled 19 charts

Neoplasm Metastasis, Paraganglioma, Pheochromocytoma

NCT04860700 2024-06-12

The Efficacy and Safety of Anlotinib in Patients With Metastatic Pheochromocytoma or Paraganglioma

27 enrolled

Neoplasm Metastasis, Paraganglioma, Paraganglioma, Extra-Adrenal, Pheochromocytoma

NCT00445965 2024-04-04

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

CNSDermatologicGynecologicOther solid neoplasmSarcomaThoracic

78 enrolled 11 charts

Familial ependymoma, Uveal Melanoma, Astrocytoma, Brain Neoplasms, Chondrosarcoma, Ependymoma, Glioblastoma, Glioma, Lung Neoplasms, Medulloblastoma, Melanoma, Neoplasm Metastasis, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Glioma, Subependymal, Gliosarcoma, Rhabdoid Tumor, Optic Nerve Glioma, Small Cell Lung Carcinoma, Desmoplastic Small Round Cell Tumor

NCT01894633 2024-01-24

CLQ

73 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT00080938 2023-06-29

Temozolomide and Radiation Therapy in Treating Patients With Brain Metastasis Secondary to Non-Small Cell Lung Cancer

26 enrolled 8 charts

Adenocarcinoma of Lung, Brain Neoplasms, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT00003308 2023-06-22

Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma

CNSDermatologicGenitourinaryGynecologicSarcoma

Brain Neoplasms, Carcinoma, Renal Cell, Chondrosarcoma, Kidney Neoplasms, Melanoma, Neoplasm Metastasis, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT05885399 2023-06-02

The Efficacy and Safety of Penpulimab in the Treatment of Metastatic PPGL Patients Who Fail to Other Systemic Treatment

Phase 2 Unknown

5 enrolled

Neoplasm Metastasis, Paraganglioma, Extra-Adrenal, Pheochromocytoma

NCT05858177 2023-05-15

MPPGL

62 enrolled

Neoplasm Metastasis, Paraganglioma, Paraganglioma, Extra-Adrenal, Pheochromocytoma

NCT02115139 2022-11-08

GRAY-B

58 enrolled 15 charts

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT03868423 2022-02-18

Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers

Brain Neoplasms, Neoplasm Metastasis

NCT01967823 2021-03-24

T Cell Receptor Immunotherapy Targeting NY-ESO-1 for Patients With NY-ESO-1 Expressing Cancer

BreastCNSDermatologicGastrointestinalThoracic

11 enrolled 12 charts

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Liver Neoplasms, Melanoma, Meningioma, Neoplasm Metastasis

NCT00031967 2020-10-22

Melatonin and Radiation Therapy in Treating Patients With Brain Metastases

Brain Neoplasms, Neoplasm Metastasis, Radiation Injuries

NCT00012116 2020-08-03

Temozolomide in Treating Patients With Solid Tumors That Have Spread to the Brain

4 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT00006259 2020-07-27

Stereotactic Radiation Therapy in Treating Patients With Brain Metastases

10 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT00276783 2020-03-05

Pemetrexed Disodium in Treating Patients With Recurrent Malignant Gliomas, Primary CNS Lymphoma, or Brain Metastases

Phase 2 Unknown

31 enrolled

CNSLymphoidSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Lymphoma, Neoplasm Metastasis, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT02584400 2019-03-08

HX4 SD

CNSGastrointestinalGenitourinary

1 enrolled

Hypoxia, Brain Neoplasms, Esophageal Neoplasms, Neoplasm Metastasis, Prostatic Neoplasms, Rectal Neoplasms

NCT00814463 2019-02-26

Stereotactic Radiosurgery After Surgery in Treating Patients With Brain Metastases

1 enrolled 6 charts

Brain Neoplasms, Neoplasm Metastasis

NCT02796729 2019-01-28

CEST- Glucose Enhanced MRI for Metastatic Brain Tumours

3 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT02866981 2018-05-09

Observation for Patients With Asymptomatic CNS Metastatic Disease

33 enrolled

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT00617539 2018-04-20

Irinotecan and Temozolomide in Treating Patients With Breast Cancer Who Have Received Previous Treatment for Brain Metastases

30 enrolled 10 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Breast Neoplasms, Male

NCT02166658 2018-01-23

CaBaMet

8 enrolled

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Recurrence

NCT01227954 2017-09-27

Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases

113 enrolled 12 charts

Brain Neoplasms, Neoplasm Metastasis

NCT01736800 2017-09-19

Phase II Trial of Chemotherapy With Temodar With Topotecan for CNS Metastasis of Solid Tumors

Brain Neoplasms, Neoplasm Metastasis

NCT00280748 2017-06-23

NRR

10 enrolled 14 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT00034697 2017-05-23

Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung Cancer (Study P02143)

24 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00076856 2017-05-09

Temozolomide for Treatment of Brain Metastases From Non-Small Cell Lung Cancer (Study P03247)

95 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00068666 2016-12-15

Temozolomide and Radiation Therapy in Treating Patients With Stage IV Malignant Melanoma With Measurable and Unresectable Cancer of the Central Nervous System

41 enrolled

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT02047747 2016-09-22

A Phase II Study of Dacomitinib in Progressive Brain Metastases

4 enrolled 4 charts

Brain Neoplasms, Neoplasm Metastasis

NCT00462982 2015-12-30

Sunitinib in Treating Patients With Brain Metastases Caused by Kidney Cancer or Melanoma

CNSDermatologicGenitourinary

8 enrolled 6 charts

Brain Neoplasms, Carcinoma, Renal Cell, Kidney Neoplasms, Melanoma, Neoplasm Metastasis

NCT00910039 2014-09-29

Sunitinib Malate After Stereotactic Radiosurgery in Treating Patients With Newly Diagnosed Brain Metastases

14 enrolled 12 charts

Brain Neoplasms, Neoplasm Metastasis

NCT01514877 2014-07-23

Icotinib Combined With Whole Brain Radiotherapy in Treating Multiple Brain Metastases From Non-Small Cell Lung Cancer

20 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT00121420 2014-05-09

Study of Motexafin Gadolinium With Whole Brain Radiation Therapy Followed by Stereotactic Radiosurgery Boost in the Treatment of Patients With Brain Metastases

BreastCNSDermatologicGenitourinaryThoracic

45 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Kidney Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT00450866 2014-02-28

Epothilone B in Treating Patients With CNS Metastases From Breast Cancer

55 enrolled 12 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Breast Neoplasms, Male, Meningeal Carcinomatosis

NCT01169116 2014-02-04

Exclusive Hypofractionated Stereotactic Radiotherapy in Non-resectable Single Brain Metastasis

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT00811655 2013-11-25

Stereotactic Radiosurgery in Treating Patients With Brain Metastases

6 enrolled 6 charts

Brain Neoplasms, Neoplasm Metastasis

NCT00385398 2013-09-02

QOL-Stereotactic RadioSurgery, Temozolomide + Erlotinib-Rx of 1-3 Brain Metastases in NSCLC

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT00003878 2013-06-21

Carmustine Implants in Treating Patients With Brain Metastases

Brain Neoplasms, Neoplasm Metastasis

NCT00301847 2013-02-11

Sorafenib in Treating Patients With Kidney Cancer That Has Spread to the Brain