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Phase

Phase 1 1

Status

Recruiting 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

Sarcoma 1Plasma cell 1Other hematologic neoplasm 1Myeloid 1Lymphoid 1Genitourinary 1Gastrointestinal 1Dermatologic 1CNS 1

Conditions

Neuroblastoma 12Recurrence 3Osteosarcoma 3Neoplasm Metastasis 3Melanoma 3Brain Neoplasms 3Sarcoma 2Rhabdomyosarcoma 2Rhabdoid Tumor 2Neurofibrosarcoma 2Neuroectodermal Tumors, Primitive, Peripheral 2Lymphoma 2Leukemia, Myelomonocytic, Juvenile 2Leukemia 2Glioma 2Glioblastoma 2Desmoplastic Small Round Cell Tumor 2Breast Neoplasms 2Wilms Tumor 1Uveal Melanoma 1Thyroid Neoplasms 1Squamous Cell Carcinoma of Head and Neck 1Sarcoma, Ewing 1Sarcoma, Clear Cell 1Precursor Cell Lymphoblastic Leukemia-Lymphoma 1Pheochromocytoma 1Paraganglioma 1Neurofibromatosis 1 1Neuroendocrine Tumors 1Neuroectodermal Tumors, Primitive 1

Interventions

Sirolimus 3Melphalan 3Granulocyte Colony-Stimulating Factor 3Cyclophosphamide 3Automobiles 3pembrolizumab 2fludarabine 2etoposide phosphate 2Stem Cell Transplantation 2Mesna 2Immunotherapy 2Gemcitabine 2Etoposide 2Carboplatin 2Busulfan 2vorasidenib 1trametinib 1tozuleristide 1sonidegib 1sodium thiosulfate 1ripretinib 1ribociclib 1pegylated granulocyte colony-stimulating factor 1lutetium Lu 177 dotatate 1interferon gamma-1b 1fludarabine phosphate 1Watchful Waiting 1Vorinostat 1Ursodeoxycholic Acid 1Topotecan 1

Date Range

30 days90 days1 yearAll

Options

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Clinical Trials

1 trials
RecentStart dateEnrollment
Neoplasms, Germ Cell and Embryonal × fludarabine phosphate × CNS × Clear all
NCT04897321 2026-05-19

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

St. Jude Children's Research Hospital

Phase 1 Recruiting
48 enrolled
CNSDermatologicGastrointestinalGenitourinarySarcoma

Adrenal Cortex Neoplasms, Carcinoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

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