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Phase

Phase 1 1

Status

Completed 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

Lymphoid 1CNS 1

Conditions

Medulloblastoma 6Recurrence 3Glioma 2Glioblastoma 2Carcinoma, Basal Cell 2Astrocytoma 2Stomach Neoplasms 1Rhabdomyosarcoma 1Rhabdoid Tumor 1Pyloric Stenosis, Hypertrophic 1Pinealoma 1Oligodendroglioma 1Neuroectodermal Tumors, Primitive 1Neuroblastoma 1Neoplasms, Neuroepithelial 1Neoplasms, Germ Cell and Embryonal 1Neoplasms 1Microphthalmia, Isolated, with Coloboma 5 1Meningioma 1Lymphoma, Follicular 1Hepatoblastoma 1Ependymoma 1Colorectal Neoplasms 1Choroid Plexus Carcinoma 1Central Nervous System Neoplasms 1Breast Neoplasms 1Brain Neoplasms 1

Interventions

Sirolimus 3Melphalan 3Granulocyte Colony-Stimulating Factor 3Cyclophosphamide 3Automobiles 3pembrolizumab 2fludarabine 2etoposide phosphate 2Stem Cell Transplantation 2Mesna 2Immunotherapy 2Gemcitabine 2Etoposide 2Carboplatin 2Busulfan 2vorasidenib 1trametinib 1tozuleristide 1sonidegib 1sodium thiosulfate 1ripretinib 1ribociclib 1pegylated granulocyte colony-stimulating factor 1lutetium Lu 177 dotatate 1interferon gamma-1b 1fludarabine phosphate 1Watchful Waiting 1Vorinostat 1Ursodeoxycholic Acid 1Topotecan 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Neoplasms, Germ Cell and Embryonal × sonidegib × CNS × Clear all
NCT03434262 2024-05-31

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

St. Jude Children's Research Hospital

Phase 1 Completed
68 enrolled
CNSLymphoid

Choroid Plexus Carcinoma, Microphthalmia, Isolated, with Coloboma 5, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Lymphoma, Follicular, Medulloblastoma, Meningioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pinealoma, Recurrence, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

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