Clinical Trials

BreastCNSGenitourinaryHead & NeckLymphoidMyeloidSarcoma

Brain Injuries, Traumatic, Margins of Excision, Caregiver Burden, Brain Injuries, Brain Neoplasms, Communication, Glioblastoma, Neoplasms, Neurologic Manifestations, Stroke

NCT01552434 2026-05-15

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Phase 1 Terminated

154 enrolled

Breast Neoplasms, Carcinoma, Transitional Cell, Endocrine Gland Neoplasms, Castleman Disease, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms, Pharyngeal Neoplasms, Recurrence, Sarcoma, Soft Tissue Neoplasms, Thyroid Neoplasms, Urologic Neoplasms, Neurofibromatosis 2, Lymphangioleiomyomatosis, Neoplasms, Mesothelial, Erdheim-Chester Disease

NCT03911388 2026-05-15

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Phase 1 Recruiting

24 enrolled

CNSSarcoma

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT00906893 2026-05-14

MISOGLIO

Phase 2 Completed

14 enrolled

Phase 2 Not yet recruiting

Hypoxia, Glioblastoma, Neoplasms

NCT06804655 2026-05-06

EViDENCE-BT

40 enrolled

Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Neurologic Manifestations

NCT04859543 2026-05-01

PPROSPERITIT

Phase NA Completed

80 enrolled

CNSGastrointestinalGenitourinaryLymphoidSarcoma

Brain Neoplasms, Neoplasms, Central Nervous System Neoplasms

NCT04084067 2026-04-30

Indocyanine Green (ICG) Guided Tumor Resection

Phase 1 Recruiting

230 enrolled

Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Lymphoma, Neoplasms, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma

NCT05297734 2026-04-30

Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicMyeloidSarcomaThoracic

2,996 enrolled

Carcinoma, Ovarian Epithelial, Breast Neoplasms, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Death, Esophageal Neoplasms, Glioblastoma, Lung Diseases, Lung Neoplasms, Melanoma, Myelodysplastic Syndromes, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Sarcoma, Osteosarcoma, Skin Neoplasms, Stomach Neoplasms, Thoracic Neoplasms, Urogenital Neoplasms, Disease Progression, Small Cell Lung Carcinoma

NCT07365124 2026-04-30

MRinRT

Not yet recruiting

165 enrolled

CNSGastrointestinal

Carcinoma, Esophageal Neoplasms, Glioblastoma, Neoplasms, Neurologic Manifestations, Pancreatic Neoplasms, Stomach Neoplasms

NCT02256137 2026-04-23

A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer

Active not recruiting

1,564 enrolled

CNSLymphoidOther hematologic neoplasm

Brain Neoplasms, Hodgkin Disease, Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03696030 2026-04-23

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

Phase 1 Active not recruiting

24 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasms, Meningeal Carcinomatosis

NCT06905587 2026-04-23

EMBRAIN

Phase 3 Recruiting

50 enrolled

Phase 2 Enrolling by invitation

Brain Neoplasms, Neoplasms

NCT04367779 2026-04-22

PROTONBIOMARKS

Completed

84 enrolled

CNSSarcoma

Brain Neoplasms, Meningioma, Neoplasms, Sarcoma

NCT07542158 2026-04-21

Ultralow Dose PET Imaging of 18F-FDOPA

200 enrolled

Glioma, Neoplasms, Parkinsonian Disorders

NCT05064280 2026-04-16

Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases

Phase 2 Recruiting

104 enrolled

Brain Neoplasms, Neoplasms

NCT05313191 2026-04-13

ReRT

BreastCNSGastrointestinalGenitourinaryHead & Neck

1,800 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Neoplasms, Prostatic Neoplasms, Central Nervous System Neoplasms

NCT04730869 2026-04-09

Metabolic Therapy Program In Conjunction With Standard Treatment For Glioblastoma

Phase NA Completed

18 enrolled

Fasting, Glioblastoma, Neoplasms

NCT00850278 2026-04-02

FLT

Phase NA Completed

50 enrolled

Brain Neoplasms, Neoplasms

NCT06850766 2026-04-02

TMZ-CHRONO

50 enrolled

Glioblastoma, Neoplasms

NCT05142033 2026-03-27

ASAP

BreastCNSGastrointestinalGynecologicOther hematologic neoplasmThoracic

25,000 enrolled

Breast Neoplasms, Colonic Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Neoplasms, Ovarian Neoplasms, Central Nervous System Neoplasms, Endometrial Neoplasms, Hematologic Neoplasms

NCT07496073 2026-03-27

A Phase I, Single-arm, Open-label Clinical Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of CHT101 Cell Infusion in Adult Subjects With Recurrent or Progressive Malignant Primary Brain Tumors（CROWN）

Phase 1 Not yet recruiting

Phase EARLY_PHASE1 Not yet recruiting

Brain Neoplasms, Neoplasms, Neurologic Manifestations

NCT07493447 2026-03-25

Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures

CNSEndocrine

Brain Neoplasms, Glioblastoma, Meningioma, Neoplasms, Neuroma, Acoustic, Pituitary Neoplasms

NCT03610906 2026-03-23

Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy

Enrolling by invitation

250 enrolled

Craniopharyngioma, Neoplasms

NCT02780128 2026-03-10

NEPENTHE

Phase 1 Terminated

66 enrolled

Neoplasms, Neuroblastoma

NCT05859659 2026-03-09

Clinical, patHOlogical and Imaging Project of nEuro-oncology (HOPE)

70,000 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Glioma, Neoplasms, Neurologic Manifestations

NCT07454668 2026-03-06

Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases

20 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT04075305 2026-03-05

MOMENTUM

BreastCNSGastrointestinalGenitourinaryHead & NeckThoracic

8,000 enrolled

Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Genital Neoplasms, Female, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Radiation Injuries, Rectal Neoplasms

NCT07450872 2026-03-05

SC-Het-GM-CCS

CNSOther hematologic neoplasm

600 enrolled

Glioma, Leukemia, Neoplasms, Syndrome, Leukemia, Myeloid, Acute

NCT05789589 2026-03-04

ADORATION

46 enrolled

Phase 2 Active not recruiting

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT02574728 2026-03-02

AflacST1502

46 enrolled

CNSMyeloidSarcoma

Brain Neoplasms, Carcinoma, Ependymoma, Histiocytosis, Langerhans-Cell, Medulloblastoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Neuroblastoma, Pinealoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT07439302 2026-02-27

NEURO-PRO-GLIO

Phase NA Not yet recruiting

80 enrolled

Phase 2/3 Not yet recruiting

Glioma, Neoplasms

NCT07440290 2026-02-27

DETERMINE

CNSEndocrineGastrointestinalGynecologicHead & NeckLymphoidMyeloidOther hematologic neoplasmPlasma cellThoracic

Thyroid Cancer, Papillary, Carcinoma, Non-Small-Cell Lung, Gastrointestinal Neoplasms, Glioma, Histiocytosis, Langerhans-Cell, Laryngeal Neoplasms, Lymphoproliferative Disorders, Multiple Myeloma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Ovarian Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms, Erdheim-Chester Disease, Thyroid Carcinoma, Anaplastic

NCT06104488 2026-02-25

A Study of Avutometinib for People With Solid Tumor Cancers

Phase 1 Recruiting

23 enrolled

Brain Neoplasms, Neoplasms, Neuroblastoma, Central Nervous System Neoplasms, Neurofibroma, Plexiform

NCT07410494 2026-02-18

SELECT-CAR-NK

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicLymphoidOther hematologic neoplasmPlasma cellThoracic

85 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Carcinoma, Hepatocellular, Liver Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Melanoma, Multiple Myeloma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Leukemia, Myeloid, Acute

NCT07410676 2026-02-18

EBNK-ST-001

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicOther hematologic neoplasmSarcomaThoracic

83 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Bronchogenic, Disease, Esophageal Neoplasms, Glioblastoma, Kidney Neoplasms, Leukemia, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms

NCT07227610 2026-02-05

Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

Phase 2 Recruiting

54 enrolled

Brain Neoplasms, Neoplasms

NCT07381959 2026-02-02

BiomarkCBT

560 enrolled

Phase 1 Active not recruiting

Brain Neoplasms, Neoplasms

NCT05421897 2026-01-29

RAPID

11 enrolled

Neoplasms, Neuroblastoma

NCT06208657 2026-01-28

Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

90 enrolled

CNSLymphoid

Lymphoma, Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT06674811 2026-01-26

BRICCS

40 enrolled

CNSGenitourinarySarcoma

Neoplasms, Wilms Tumor, Neuroblastoma, Sarcoma

NCT04181684 2026-01-23

GCCC 19140

32 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms

NCT06468176 2025-12-19

FREEDOME

187 enrolled

Glioma, Neoplasms, Nervous System Diseases

NCT03086421 2025-12-05

Social Emotional Development in Young Children With Cancer

Active not recruiting

119 enrolled

Brain Neoplasms, Neoplasms, Social Adjustment

NCT04391062 2025-12-05

DOSINDYGO

Phase 2 Completed

14 enrolled

Glioblastoma, Neoplasms

NCT04306484 2025-12-04

FDOPA

Completed

74 enrolled

Brain Neoplasms, Neoplasms

NCT03702309 2025-11-26

LIBERATE

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellThoracic

2,500 enrolled

Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Hamartoma Syndrome, Multiple, Head and Neck Neoplasms, Kidney Neoplasms, Leukemia, Lung Neoplasms, Lymphoma, Melanoma, Meningioma, Neoplasms, Ovarian Neoplasms, Uterine Neoplasms, Neoplasms, Plasma Cell

NCT05768178 2025-11-24

DETERMINE

Phase 2/3 Recruiting

CNSDermatologicEndocrineGastrointestinalGynecologicHead & NeckMyeloidOther hematologic neoplasmPlasma cellThoracic

Thyroid Cancer, Papillary, Carcinoma, Non-Small-Cell Lung, Glioma, Laryngeal Neoplasms, Melanoma, Multiple Myeloma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Ovarian Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms, Erdheim-Chester Disease, Thyroid Carcinoma, Anaplastic

NCT05770037 2025-11-24

DETERMINE

Phase 2/3 Recruiting