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Phase

Phase 1 1

Status

Active not recruiting 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

Sarcoma 4Other solid neoplasm 2Gastrointestinal 2Dermatologic 2Thoracic 1Genitourinary 1CNS 1

Conditions

Glioblastoma 40Brain Neoplasms 34Melanoma 15Glioma 13Carcinoma, Non-Small-Cell Lung 9Gliosarcoma 7Neoplasms 6Carcinoma, Renal Cell 6Stomach Neoplasms 5Ovarian Neoplasms 4Meningioma 4Lung Neoplasms 4Esophageal Neoplasms 4Colorectal Neoplasms 4Breast Neoplasms 4Astrocytoma 4Uterine Cervical Neoplasms 3Triple Negative Breast Neoplasms 3Sarcoma 3Recurrence 3Central Nervous System Neoplasms 3Uveal Melanoma 2Turcot syndrome 2Squamous Cell Carcinoma of Head and Neck 2Small Cell Lung Carcinoma 2Parkinson Disease 4, Autosomal Dominant Lewy Body 2Pancreatic Neoplasms 2Neuroblastoma 2Neoplasms, Germ Cell and Embryonal 2Neoplasm Metastasis 2

Interventions

Magnetic Resonance Spectroscopy 3AZD 6244 3fludarabine phosphate 2Specimen Handling 2Nivolumab 2Etoposide 2thymoglobulin 1pembrolizumab 1lorvotuzumab mertansine 1fludarabine 1X-Rays 1Trabectedin 1Thiotepa 1Tacrolimus 1Surgical Procedures, Operative 1Stem Cell Transplantation 1Sirolimus 1Radiotherapy 1Photons 1Neurofibromin 1 1Mycophenolic Acid 1Mesna 1Melphalan 1Liquid Biopsy 1Ipilimumab 1Imatinib Mesylate 1Ifosfamide 1High-Energy Shock Waves 1Filgrastim 1Doxorubicin 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Neurofibrosarcoma × pembrolizumab × CNS × Clear all
NCT04483778 2026-04-28

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Seattle Children's Hospital

Phase 1 Active not recruiting
68 enrolled
CNSDermatologicGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Carcinoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

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