Clinical Trials

Astrocytoma, Glioma, Oligodendroglioma

NCT03911388 2026-05-15

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Phase 1 Recruiting

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT02192359 2026-05-11

Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas

18 enrolled 16 charts

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT03975829 2026-05-11

Pediatric Long-Term Follow-up and Rollover Study

Phase 4 Recruiting

165 enrolled

CNSMyeloid

Astrocytoma, Ganglioneuroma, Glioblastoma, Glioma, Histiocytosis, Langerhans-Cell, Neuroblastoma, Neurofibromatosis 1, Oligodendroglioma, Ganglioglioma, Neurocytoma, Neurofibroma, Plexiform

NCT00268385 2026-05-07

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

83 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT04105374 2026-05-07

Testing the Addition of an Anti-cancer Viral Gene Therapy, Toca 511/Toca FC, to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed Glioblastoma

Phase 2/3 Withdrawn

Astrocytoma, Glioblastoma, Oligodendroglioma

NCT04755023 2026-05-07

TEMOBIC

Phase 2 Completed

53 enrolled

Astrocytoma, Oligodendroglioma

NCT05190172 2026-05-01

PRO-GLIO

Phase NA Recruiting

225 enrolled

Astrocytoma, Oligodendroglioma

NCT06625047 2026-04-29

Comparing Telehealth and In-person Assessments in Glioma Patients Receiving Oral Chemotherapy

Phase 4 Completed

30 enrolled

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma

NCT06108206 2026-04-27

Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

Active not recruiting

20 enrolled

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma

NCT05513859 2026-04-24

Investigational Imaging Technique During Brain Surgery

Phase NA Suspended

Astrocytoma, Glioblastoma, Oligodendroglioma

NCT05934630 2026-04-23

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

Terminated

57 enrolled

Choroid Plexus Carcinoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Rhabdoid Tumor

NCT07462507 2026-04-21

Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

Phase 2 Recruiting

104 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT05698524 2026-04-17

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

Phase 1 Recruiting

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02381886 2026-04-13

A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations

CNSGastrointestinalMyeloidOther hematologic neoplasm

166 enrolled

Astrocytoma, Glioblastoma, Glioma, Leukemia, Myelodysplastic Syndromes, Oligodendroglioma, Leukemia, Myeloid, Acute, Cholangiocarcinoma

NCT07468136 2026-04-13

Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas

Phase 1/2 Not yet recruiting

33 enrolled

CNSLymphoid

Astrocytoma, Glioblastoma, Glioma, Lymphoma, Follicular, Oligodendroglioma

NCT04978727 2026-04-06

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

35 enrolled

Phase EARLY_PHASE1 Terminated

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Ependymoma, Glioblastoma, Medulloblastoma, Oligodendroglioma

NCT03796273 2026-03-20

Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases

15 enrolled

Phase EARLY_PHASE1 Completed

Astrocytoma, Glioma, Oligodendroglioma

NCT05577416 2026-03-18

AB-218-IIT-201

14 enrolled

Astrocytoma, Glioma, Oligodendroglioma

NCT05393258 2026-03-17

Temporally-modulated Pulsed Radiation Therapy (TMPRT) After Prior EBRT for Recurrent IDH-mutant Gliomas

Phase NA Completed

13 enrolled

Astrocytoma, Glioma, Oligodendroglioma

NCT05484622 2026-03-12

Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive IDH-1 Mutant Glioma

60 enrolled

Astrocytoma, Oligodendroglioma

NCT05303519 2026-03-05

SIGMA

Phase 3 Recruiting

365 enrolled

CNSLymphoid

Astrocytoma, Glioblastoma, Glioma, Lymphoma, Follicular, Oligodendroglioma

NCT03152318 2026-03-04

rQNestin

62 enrolled

Astrocytoma, Brain Neoplasms, Disease, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Ganglioglioma

NCT06665724 2026-02-27

Clinical Trial Evaluating Safety of 5-Aminolevulinic Acid (5-ALA) Combined With CV01 Delivery of Ultrasound for Sonodynamic Therapy (SDT) in Patients With Newly Diagnosed High-Grade Glioma (HGG) Prior to Resection and Standard Adjuvant Therapy (ALA SDT GLIOMA 401)

Phase 1 Completed

16 enrolled

Phase 2 Not yet recruiting

Astrocytoma, Glioblastoma, Oligodendroglioma

NCT07439172 2026-02-27

PRC

70 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT05345002 2026-02-20

All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

Phase 2 Recruiting

55 enrolled

Astrocytoma, Glioma, Oligodendroglioma

NCT04923126 2026-02-04

SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma

Phase 1/2 Recruiting

132 enrolled

Astrocytoma, Ganglioneuroma, Oligodendroglioma, Neoplasms, Neuroepithelial, Ganglioglioma, Neurocytoma

NCT05331521 2026-02-03

ImproveCodel

Phase 3 Recruiting

406 enrolled

Oligodendroglioma

NCT04702581 2026-01-29

POLO

Phase 3 Recruiting

280 enrolled

Phase 3 Active not recruiting

Oligodendroglioma

NCT00887146 2026-01-22

Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

305 enrolled

Astrocytoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT04623931 2026-01-14

Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas

Phase 2 Recruiting

40 enrolled

Astrocytoma, Glioblastoma, Oligodendroglioma

NCT04295759 2026-01-05

INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

Phase 1 Completed

13 enrolled 15 charts

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Pyloric Stenosis, Hypertrophic

NCT05267106 2025-12-30

FIGHT-209

Phase 2 Terminated

83 enrolled 18 charts

Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT04541082 2025-12-18

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Phase 1 Recruiting

102 enrolled

Typical Teratoid Rhabdoid Tumor, Astrocytoma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma

NCT07031765 2025-12-18

Peds CHAMP1ON

12 enrolled

Astrocytoma, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma

NCT05956821 2025-12-08

Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age

Phase 1/2 Recruiting

20 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Oligodendroglioma

NCT06930846 2025-11-21

HOBSCOTCH-CA

Phase NA Recruiting

125 enrolled

Caregiver Burden, Brain Neoplasms, Memory Disorders, Meningioma, Oligodendroglioma, Cognitive Dysfunction

NCT06439420 2025-10-01

CBT-I in PBT

Phase 2 Completed

70 enrolled

CNSLymphoid

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Sleep Initiation and Maintenance Disorders, Lymphoma, Meningioma, Oligodendroglioma

NCT01849952 2025-09-15

Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas

Terminated

94 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma

NCT06989086 2025-09-09

FearLess in NeuroOncology

Phase NA Recruiting

112 enrolled

Phase 3 Active not recruiting

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma

NCT00978458 2025-09-08

Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma

540 enrolled

Astrocytoma, Brain Neoplasms, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Neurotoxicity Syndromes

NCT07159607 2025-09-08

APPEAR

Recruiting

100 enrolled

Phase EARLY_PHASE1 Completed

Astrocytoma, Glioma, Oligodendroglioma

NCT01165632 2025-09-02

Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma

Astrocytoma, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Glioma, Subependymal, Gliosarcoma

NCT06038760 2025-07-30

PEAR-GLIO

Terminated

12 enrolled

Phase EARLY_PHASE1 Recruiting

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms, Oligodendroglioma

NCT04135807 2025-07-23

Implantable Microdevice In Primary Brain Tumors

12 enrolled

Phase 2 Active not recruiting

Astrocytoma, Glioblastoma, Oligodendroglioma

NCT03220646 2025-07-09

Abemaciclib (LY2835219) in Patients With Recurrent Primary Brain Tumors

64 enrolled