Clinical Trials

Medulloblastoma, Recurrence

NCT03970447 2026-04-08

GBM AGILE

Phase 2/3 Recruiting

2,250 enrolled

Glioblastoma, Recurrence

NCT01822652 2026-04-06

GRAIN

11 enrolled

Neuroblastoma, Recurrence

NCT07502287 2026-03-30

DUAL-NK-NB

36 enrolled

Neuroblastoma, Recurrence, Ganglioneuroblastoma

NCT05184816 2026-03-27

A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis

Phase 1 Recruiting

35 enrolled

Phase 1/2 Active not recruiting

Recurrence, Meningeal Carcinomatosis

NCT02650401 2026-03-25

STARTRK-NG

69 enrolled 2 FDA

CNSEndocrineGenitourinaryHead & NeckSarcoma

Thyroid Cancer, Papillary, Brain Neoplasms, Glioma, Medulloblastoma, Neoplasm Metastasis, Wilms Tumor, Neuroblastoma, Recurrence, Salivary Gland Neoplasms, Sarcoma, Sarcoma, Ewing, Central Nervous System Neoplasms, Nephroma, Mesoblastic

NCT02298348 2026-03-23

N2013-02

18 enrolled

BreastCNSGastrointestinalGenitourinaryGynecologicThoracic

Neuroblastoma, Recurrence

NCT05283330 2026-03-20

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

Phase 1 Recruiting

48 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Colonic Neoplasms, Glioblastoma, Neoplasm Metastasis, Prostatic Neoplasms, Recurrence, Colorectal Neoplasms

NCT06161519 2026-03-19

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

146 enrolled

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Recurrence

NCT02115074 2026-03-18

FLUVABREX

Phase 1 Completed

20 enrolled

Phase 1/2 Not yet recruiting

Glioma, Recurrence

NCT06639607 2026-03-10

PRiME II

68 enrolled

Diffuse Intrinsic Pontine Glioma, Ependymoma, Medulloblastoma, Recurrence

NCT01356290 2026-02-23

MEMMAT

Phase 2 Recruiting

232 enrolled

Ependymoma, Medulloblastoma, Recurrence

NCT02669173 2026-02-23

Capecitabine + Bevacizumab in Patients With Recurrent Glioblastoma

Phase 1 Completed

12 enrolled

Brain Neoplasms, Glioblastoma, Recurrence

NCT02942264 2026-02-23

Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma

Phase 1/2 Terminated

53 enrolled 22 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Recurrence, Gliosarcoma

NCT05124912 2026-02-20

REMASTer: REcurrent Brain Metastases After SRS Trial

Phase NA Recruiting

261 enrolled

Phase 2 Not yet recruiting

Brain Neoplasms, Neoplasm Metastasis, Recurrence

NCT07424092 2026-02-20

PED-DNX2401

39 enrolled

Ependymoma, Glioma, Recurrence

NCT07263438 2026-02-13

Phenix

Phase 2 Recruiting

59 enrolled

Glioblastoma, Recurrence

NCT05629702 2026-01-30

ARISTOCRAT

Phase 2 Recruiting

120 enrolled

Brain Neoplasms, Marijuana Abuse, Glioblastoma, Recurrence

NCT06208657 2026-01-28

Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

90 enrolled

CNSLymphoid

Lymphoma, Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT05084430 2026-01-22

Study of Pembrolizumab and M032 (NSC 733972)

28 enrolled

CNSSarcoma

Astrocytoma, Glioblastoma, Recurrence, Gliosarcoma

NCT06193174 2026-01-22

Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1)

Phase 1 Terminated

1 enrolled

Brain Neoplasms, Glioma, Recurrence

NCT04773782 2026-01-13

A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling

Phase 1/2 Completed

29 enrolled

Phase 1 Not yet recruiting

Glioma, Recurrence, Central Nervous System Neoplasms

NCT07331064 2026-01-09

GABRIEL

15 enrolled

Phase EARLY_PHASE1 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Recurrence, Rhabdoid Tumor

NCT04656535 2026-01-07

AB154 Combined With AB122 for Recurrent Glioblastoma

46 enrolled

Phase 1/2 Active not recruiting

Glioblastoma, Recurrence

NCT02932280 2025-12-05

Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment

14 enrolled

CNSLymphoidOther hematologic neoplasm

Disease, Leukemia, Lymphoma, Recurrence, Central Nervous System Neoplasms

NCT03233152 2025-11-21

GlitIpNi

Phase 1/2 Active not recruiting

110 enrolled

Glioblastoma, Recurrence

NCT05768880 2025-11-20

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

72 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT03557359 2025-11-03

Nivolumab for Recurrent or Progressive IDH Mutant Gliomas

Phase 2 Completed

35 enrolled 9 charts

Glioma, Recurrence

NCT05366179 2025-10-20

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

Phase 1 Recruiting

36 enrolled

Brain Neoplasms, Glioblastoma, Recurrence

NCT01552434 2025-10-14

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease