Clinical Trials

BreastCNSGenitourinaryHead & NeckLymphoidMyeloidSarcoma

Ependymoma, Glioma, Recurrence

NCT01552434 2026-05-15

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Phase 1 Terminated

154 enrolled

Breast Neoplasms, Carcinoma, Transitional Cell, Endocrine Gland Neoplasms, Castleman Disease, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms, Pharyngeal Neoplasms, Recurrence, Sarcoma, Soft Tissue Neoplasms, Thyroid Neoplasms, Urologic Neoplasms, Neurofibromatosis 2, Lymphangioleiomyomatosis, Neoplasms, Mesothelial, Erdheim-Chester Disease

NCT03970447 2026-05-15

GBM AGILE

Phase 2/3 Recruiting

2,250 enrolled

Glioblastoma, Recurrence

NCT06161519 2026-05-13

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

146 enrolled

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Recurrence

NCT07584499 2026-05-13

MRG003

CNSGenitourinaryHead & NeckSarcoma

51 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Medulloblastoma, Neoplasm Metastasis, Wilms Tumor, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Rhabdoid Tumor

NCT04337177 2026-05-11

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Phase 1 Active not recruiting

20 enrolled

CNSGastrointestinalSarcoma

Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Hepatoblastoma

NCT05629702 2026-05-05

ARISTOCRAT

Phase 2 Recruiting

120 enrolled

Phase 1/2 Not yet recruiting

Brain Neoplasms, Marijuana Abuse, Glioblastoma, Recurrence

NCT07567469 2026-05-05

A Safety and Efficacy Study of Combined Fianlimab + Cemiplimab in Children and Young Adults With Recurrent or Progressive High-Grade Glioma or Posterior Fossa-A Ependymoma

120 enrolled

Ependymoma, Glioma, Neoplasms, Recurrence

NCT05588141 2026-05-01

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

96 enrolled

Brain Neoplasms, Glioma, Neoplasms, Recurrence

NCT05283330 2026-04-30

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

BreastCNSGastrointestinalGenitourinaryGynecologicThoracic

48 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Colonic Neoplasms, Glioblastoma, Neoplasm Metastasis, Prostatic Neoplasms, Recurrence, Colorectal Neoplasms

NCT03154996 2026-04-22

Chronic Convection Enhanced Delivery of Topotecan

Phase 1 Completed

5 enrolled

Glioma, Recurrence

NCT05366179 2026-04-22

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

36 enrolled

Phase EARLY_PHASE1 Active not recruiting

Brain Neoplasms, Glioblastoma, Recurrence

NCT04656535 2026-04-17

AB154 Combined With AB122 for Recurrent Glioblastoma

46 enrolled

Glioblastoma, Recurrence

NCT04670016 2026-04-15

HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers

Completed

20 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Radiation Injuries, Recurrence

NCT06721689 2026-04-15

PEEL-224

59 enrolled

CNSSarcoma

Neuroblastoma, Recurrence, Rhabdomyosarcoma

NCT06607692 2026-04-14

LUPARPED

25 enrolled

CNSEndocrineNETSarcoma

Adrenal Cortex Neoplasms, Adrenal Gland Neoplasms, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neuroblastoma, Paraganglioma, Pheochromocytoma, Recurrence, Osteosarcoma, Sarcoma, Synovial, Esthesioneuroblastoma, Olfactory, Neuroendocrine Tumors

NCT07242963 2026-04-13

Relapsed and Progressive Sonic Hedgehog Medulloblastoma With U1 Mutation Registry Study

Recruiting

300 enrolled

Phase 1 Active not recruiting

Medulloblastoma, Recurrence

NCT01822652 2026-04-06

GRAIN

11 enrolled

Neuroblastoma, Recurrence

NCT07502287 2026-03-30

DUAL-NK-NB

36 enrolled

Neuroblastoma, Recurrence, Ganglioneuroblastoma

NCT05184816 2026-03-27

A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis

35 enrolled

Phase 1/2 Active not recruiting

Recurrence, Meningeal Carcinomatosis

NCT02650401 2026-03-25

STARTRK-NG

69 enrolled 1 FDA

CNSEndocrineGenitourinaryHead & NeckSarcoma

Thyroid Cancer, Papillary, Brain Neoplasms, Glioma, Medulloblastoma, Neoplasm Metastasis, Wilms Tumor, Neuroblastoma, Recurrence, Salivary Gland Neoplasms, Sarcoma, Sarcoma, Ewing, Central Nervous System Neoplasms, Nephroma, Mesoblastic

NCT02298348 2026-03-23

N2013-02

Phase 1 Active not recruiting

18 enrolled

Neuroblastoma, Recurrence

NCT02115074 2026-03-18

FLUVABREX

Phase 1 Completed

20 enrolled

Phase 1/2 Not yet recruiting

Glioma, Recurrence

NCT06639607 2026-03-10

PRiME II

68 enrolled