Clinical Trials

35 enrolled

Phase 1 Active not recruiting

Recurrence, Meningeal Carcinomatosis

NCT02298348 2026-03-23

N2013-02

18 enrolled

Neuroblastoma, Recurrence

NCT05283330 2026-03-20

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

BreastCNSGastrointestinalGenitourinaryGynecologicThoracic

48 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Colonic Neoplasms, Glioblastoma, Neoplasm Metastasis, Prostatic Neoplasms, Recurrence, Colorectal Neoplasms

NCT02115074 2026-03-18

FLUVABREX

Glioma, Recurrence

NCT02669173 2026-02-23

Capecitabine + Bevacizumab in Patients With Recurrent Glioblastoma

Brain Neoplasms, Glioblastoma, Recurrence

NCT06193174 2026-01-22

Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1)

1 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Glioma, Recurrence

NCT07331064 2026-01-09

GABRIEL

15 enrolled

Phase 1 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Recurrence, Rhabdoid Tumor

NCT05768880 2025-11-20

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

72 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT05366179 2025-10-20

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

36 enrolled

Phase 1 Active not recruiting

Brain Neoplasms, Glioblastoma, Recurrence

NCT01552434 2025-10-14

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

155 enrolled

BreastCNSGenitourinaryHead & NeckLymphoidMyeloidSarcoma

Breast Neoplasms, Carcinoma, Transitional Cell, Endocrine Gland Neoplasms, Castleman Disease, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms, Pharyngeal Neoplasms, Recurrence, Sarcoma, Soft Tissue Neoplasms, Thyroid Neoplasms, Urologic Neoplasms, Neurofibromatosis 2, Lymphangioleiomyomatosis, Neoplasms, Mesothelial, Erdheim-Chester Disease

NCT05429502 2025-10-10

Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

Glioma, Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma

NCT04337177 2025-09-23

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

CNSGastrointestinalSarcoma

Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Hepatoblastoma

NCT02766699 2025-06-03

CerebralEDV

9 enrolled

Brain Neoplasms, Glioblastoma, Neoplasms, Neoplasms by Site, Recurrence, Disease Progression

NCT06674265 2025-04-09

Safety and Efficacy of Systemic Allogenic NK Cells in R/R Neuroblastoma

10 enrolled

Neuroblastoma, Recurrence

NCT06751134 2025-02-07

Chimeric Natural Killer Receptor-Universal T Cells for Relapsed or Refractory Neuroblastoma

Neuroblastoma, Recurrence

NCT04908176 2024-12-13

A Drug-drug Interaction Study of Avapritinib and Midazolam

CNSGastrointestinalSarcoma

10 enrolled

Glioblastoma, Neoplasms, Recurrence, Gastrointestinal Stromal Tumors

NCT00867568 2024-08-06

TPI 287 in Patients With Refractory or Recurrent Neuroblastoma or Medulloblastoma

18 enrolled 12 charts

Medulloblastoma, Neuroblastoma, Recurrence

NCT04047303 2024-07-05

CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma

Astrocytoma, Glioblastoma, Recurrence

NCT03434262 2024-05-31

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

68 enrolled

CNSLymphoid

Choroid Plexus Carcinoma, Microphthalmia, Isolated, with Coloboma 5, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Lymphoma, Follicular, Medulloblastoma, Meningioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pinealoma, Recurrence, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

NCT02962167 2024-03-20

Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT

34 enrolled

Medulloblastoma, Recurrence, Rhabdoid Tumor

NCT04341311 2024-02-15

DIPG

4 enrolled

Diffuse Intrinsic Pontine Glioma, Neoplasms, Recurrence

NCT02193347 2023-12-01

RESIST

24 enrolled 8 charts

Brain Neoplasms, Recurrence

NCT02644460 2023-10-26

AflacST1501

53 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT03236857 2023-05-22

A Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young Adult Patients With Relapsed or Refractory Malignancies

CNSLymphoidOther hematologic neoplasm

143 enrolled

Lymphoma, Non-Hodgkin, Neoplasms, Neuroblastoma, Recurrence, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01528046 2023-01-13

Metformin in Children With Relapsed or Refractory Solid Tumors

26 enrolled

Brain Neoplasms, Neoplasms, Recurrence

NCT03154996 2022-07-05

Chronic Convection Enhanced Delivery of Topotecan

5 enrolled

Glioma, Recurrence

NCT02013336 2022-03-31

Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophosphamide in Recurrent or Refractory Pediatric Solid Tumors

Phase 1 Unknown

30 enrolled

Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT02163356 2022-03-31

SPOC2013-001

4 enrolled

Neuroblastoma, Recurrence

NCT02564198 2021-08-17

A Study of Ramucirumab (LY3009806) in Children With Refractory Solid Tumors

29 enrolled 12 charts

Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT02761915 2021-08-17

A Phase I Trial of Anti-GD2 T-cells (1RG-CART)

17 enrolled 17 charts

Cytokine Release Syndrome, Neuroblastoma, Recurrence

NCT03423992 2021-06-15

Personalized Chimeric Antigen Receptor T Cell Immunotherapy for Patients With Recurrent Malignant Gliomas

Phase 1 Unknown

100 enrolled

Glioma, Recurrence

NCT03615404 2021-01-28

ATTAC-P

11 enrolled 7 charts

Astrocytoma, Glioblastoma, Glioma, Medulloblastoma, Recurrence

NCT02748135 2021-01-13

A Study of TB-403 in Pediatric Subjects With Relapsed or Refractory Medulloblastoma

18 enrolled

Medulloblastoma, Neuroblastoma, Recurrence, Sarcoma, Ewing, Rhabdomyosarcoma, Alveolar

NCT01106508 2020-12-17

A Dose Finding and Safety Study of Oral LEQ506 in Patients With Advanced Solid Tumors

57 enrolled

CNSDermatologic

Carcinoma, Basal Cell, Medulloblastoma, Recurrence

NCT01331135 2020-05-29

Aflac ST0901

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

18 enrolled

Astrocytoma, Carcinoma, Renal Cell, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Recurrence, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT01316809 2019-12-12

AZD8055 for Adults With Recurrent Gliomas

22 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Oligodendroglioma, Recurrence

NCT01135563 2019-09-20

Study of Vinblastine and Sirolimus in Children With Recurrent/Refractory Solid Tumours Including CNS Tumours

14 enrolled

Recurrence, Central Nervous System Neoplasms

NCT01460901 2019-07-23

STALLONe

5 enrolled 11 charts

Neuroblastoma, Recurrence

NCT01313936 2019-04-29

High-Dose 131I-MIBG Therapy Combined With Vincristine and Five Days of Irinotecan for Resistant/Relapsed Neuroblastoma

32 enrolled 8 charts

Neoplasms, Neuroblastoma, Recurrence

NCT03101579 2019-03-19

Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer

13 enrolled

Recurrence, Meningeal Carcinomatosis

NCT02176720 2018-08-17

Response Monitoring Trial in Patients With Suspected Recurrence of Glioblastoma

31 enrolled

Glioblastoma, Glioma, Recurrence

NCT01462396 2018-07-18

STALLO

4 enrolled

Neuroblastoma, Recurrence

NCT01956734 2017-10-24

D24GBM

31 enrolled

Glioblastoma, Recurrence

NCT00509691 2017-05-09

Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy

BreastCNSDermatologicGenitourinaryGynecologicLymphoidMyeloidOther hematologic neoplasmPlasma cellSarcoma

Pdgfra-Associated Chronic Eosinophilic Leukemia, Congenital Abnormalities, Carcinoma, Ovarian Epithelial, Blast Crisis, Breast Neoplasms, Burkitt Lymphoma, Hodgkin Disease, Infections, Leukemia, Hairy Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Multiple Myeloma, Mycosis Fungoides, Myeloproliferative Disorders, Neoplasms, Wilms Tumor, Neuroblastoma, Recurrence, Sezary Syndrome, Testicular Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Neutrophilic, Chronic, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Dendritic Cell Sarcoma, Interdigitating, Primary Myelofibrosis

NCT01241162 2017-05-09

Decitabine Followed by a Cancer Antigen Vaccine for Patients With Neuroblastoma and Sarcoma

19 enrolled

Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial

NCT01972750 2016-04-19

TKI258

Phase 1 Unknown

Glioblastoma, Recurrence

NCT00756340 2015-10-14

A Trial of Everolimus and Bevacizumab in Children With Recurrent Solid Tumors

16 enrolled

Recurrence, Central Nervous System Neoplasms

NCT00187174 2015-03-04

Everolimus for Treating Pediatric Patients With Recurrent or Refractory Tumors

41 enrolled

Brain Neoplasms, Neoplasms, Recurrence, Rhabdomyosarcoma, Sarcoma

NCT01088763 2014-11-05

Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia