Clinical Trials

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Radiation Injuries, Recurrence

NCT06721689 2026-04-15

PEEL-224

59 enrolled

CNSSarcoma

Neuroblastoma, Recurrence, Rhabdomyosarcoma

NCT06607692 2026-04-14

LUPARPED

25 enrolled

CNSEndocrineNETSarcoma

Adrenal Cortex Neoplasms, Adrenal Gland Neoplasms, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neuroblastoma, Paraganglioma, Pheochromocytoma, Recurrence, Osteosarcoma, Sarcoma, Synovial, Esthesioneuroblastoma, Olfactory, Neuroendocrine Tumors

NCT07242963 2026-04-13

Relapsed and Progressive Sonic Hedgehog Medulloblastoma With U1 Mutation Registry Study

Recruiting

300 enrolled

Medulloblastoma, Recurrence

NCT03970447 2026-04-08

GBM AGILE

Phase 2/3 Recruiting

2,250 enrolled

Glioblastoma, Recurrence

NCT01822652 2026-04-06

GRAIN

11 enrolled

Neuroblastoma, Recurrence

NCT05184816 2026-03-27

A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis

Phase 1 Recruiting

35 enrolled

Recurrence, Meningeal Carcinomatosis

NCT02298348 2026-03-23

N2013-02

18 enrolled

Neuroblastoma, Recurrence

NCT02115074 2026-03-18

FLUVABREX

20 enrolled

Phase 1/2 Not yet recruiting

Glioma, Recurrence

NCT06639607 2026-03-10

PRiME II

68 enrolled

Diffuse Intrinsic Pontine Glioma, Ependymoma, Medulloblastoma, Recurrence

NCT01356290 2026-02-23

MEMMAT

232 enrolled

Ependymoma, Medulloblastoma, Recurrence

NCT02669173 2026-02-23

Capecitabine + Bevacizumab in Patients With Recurrent Glioblastoma

12 enrolled

Phase 2 Not yet recruiting

Brain Neoplasms, Glioblastoma, Recurrence

NCT07424092 2026-02-20

PED-DNX2401

39 enrolled

Ependymoma, Glioma, Recurrence

NCT07263438 2026-02-13

Phenix

59 enrolled

Glioblastoma, Recurrence

NCT05629702 2026-01-30

ARISTOCRAT

120 enrolled

Brain Neoplasms, Marijuana Abuse, Glioblastoma, Recurrence

NCT06208657 2026-01-28

Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

90 enrolled

CNSLymphoid

Lymphoma, Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT05084430 2026-01-22

Study of Pembrolizumab and M032 (NSC 733972)

28 enrolled

CNSSarcoma

Astrocytoma, Glioblastoma, Recurrence, Gliosarcoma

NCT06193174 2026-01-22

Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1)

Phase 1 Terminated

1 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Glioma, Recurrence

NCT07331064 2026-01-09

GABRIEL

15 enrolled

Phase EARLY_PHASE1 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma, Recurrence, Rhabdoid Tumor

NCT04656535 2026-01-07

AB154 Combined With AB122 for Recurrent Glioblastoma

46 enrolled

Phase 1/2 Active not recruiting

Glioblastoma, Recurrence

NCT02932280 2025-12-05

Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment

14 enrolled

CNSLymphoidOther hematologic neoplasm

Disease, Leukemia, Lymphoma, Recurrence, Central Nervous System Neoplasms

NCT03233152 2025-11-21

GlitIpNi

Phase 1/2 Active not recruiting

110 enrolled

Glioblastoma, Recurrence

NCT05768880 2025-11-20

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

72 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT03557359 2025-11-03

Nivolumab for Recurrent or Progressive IDH Mutant Gliomas

Phase 2 Completed

35 enrolled 9 charts

Glioma, Recurrence

NCT05366179 2025-10-20

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

Phase 1 Recruiting

36 enrolled

Brain Neoplasms, Glioblastoma, Recurrence

NCT01552434 2025-10-14

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

BreastCNSGenitourinaryHead & NeckLymphoidMyeloidSarcoma

155 enrolled

Breast Neoplasms, Carcinoma, Transitional Cell, Endocrine Gland Neoplasms, Castleman Disease, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms, Pharyngeal Neoplasms, Recurrence, Sarcoma, Soft Tissue Neoplasms, Thyroid Neoplasms, Urologic Neoplasms, Neurofibromatosis 2, Lymphangioleiomyomatosis, Neoplasms, Mesothelial, Erdheim-Chester Disease

NCT05634707 2025-09-22

Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT)

Phase EARLY_PHASE1 Active not recruiting

10 enrolled

Brain Neoplasms, Glioma, Recurrence

NCT03561870 2025-09-12

OLAGLI

Phase 2 Completed

35 enrolled

Glioma, Recurrence

NCT03672721 2025-08-11

IA Carboplatin + Radiotherapy in Relapsing GBM

35 enrolled

Phase 2 Active not recruiting

Glioblastoma, Recurrence

NCT04469075 2025-08-08

Clindamycin and Triamcinolone in People With Glioblastoma to Prevent Skin-Related Side Effects of Tumor Treating Fields

48 enrolled

Glioblastoma, Recurrence

NCT06356883 2025-08-07

Intraarterial Carboplatin + Caelyx vs Intraarterial Carboplatin + Etoposide Phosphate for Progressing Glioblastoma

120 enrolled

Glioblastoma, Recurrence

NCT06430424 2025-07-30

GBrecurr

Recruiting

40 enrolled

Glioblastoma, Recurrence

NCT01370330 2025-07-22

131I-Labeled MIBG for Refractory Neuroblastoma: A Compassionate Use Protocol

Available

Phase EARLY_PHASE1 Recruiting

Neoplasms, Neuroblastoma, Recurrence

NCT05432518 2025-04-25

Pilot Trial for Treatment of Recurrent Glioblastoma

10 enrolled

Glioblastoma, Recurrence

NCT06751134 2025-02-07

Chimeric Natural Killer Receptor-Universal T Cells for Relapsed or Refractory Neuroblastoma

Phase 1 Recruiting

12 enrolled

Neuroblastoma, Recurrence

NCT06801730 2025-01-30

NALIRIBVRG

38 enrolled

Phase 1/2 Active not recruiting

Glioma, Recurrence

NCT04758533 2024-12-27

AloCELYVIR

13 enrolled

Phase EARLY_PHASE1 Recruiting

Diffuse Intrinsic Pontine Glioma, Medulloblastoma, Recurrence

NCT06684639 2024-12-20

A Study on the Efficacy of GD2-CAR T Cells in the Treatment of Neuroblastoma

30 enrolled

Phase NA Active not recruiting

Neuroblastoma, Recurrence

NCT03075072 2024-10-23

Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial

196 enrolled

BreastCNSDermatologicGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Kidney Neoplasms, Lung Neoplasms, Melanoma, Recurrence

NCT04267978 2024-10-15

Study of Recombinant Human Endostatin Combined with Temozolomide and Irinotecan in Recurrent Gliomas

109 enrolled

Glioblastoma, Recurrence

NCT03925675 2024-09-03

18F-Fluciclovine PET and Multiparametric MR Imaging

Phase 2 Withdrawn

Brain Neoplasms, Recurrence

NCT05095766 2024-08-23

ITIRR

Completed

40 enrolled

Brain Neoplasms, Recurrence

NCT00867568 2024-08-06

TPI 287 in Patients With Refractory or Recurrent Neuroblastoma or Medulloblastoma

18 enrolled 12 charts

Medulloblastoma, Neuroblastoma, Recurrence

NCT02846038 2024-07-25

Understanding Communication in Healthcare to Achieve Trust (U-CHAT)

Completed

138 enrolled

Brain Neoplasms, Communication, Neoplasms, Recurrence, Disease Progression

NCT03015844 2024-07-05

A Compassionate Use/Expanded Access Protocol Using 131I-MIBG Therapy for Patients With Refractory Neuroblastoma and Metastatic Pheochromocytoma

Available

CNSEndocrine

Neuroblastoma, Pheochromocytoma, Recurrence

NCT03434262 2024-05-31

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors