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Phase

Phase 1 1

Status

Active not recruiting 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

Sarcoma 1Other solid neoplasm 1Genitourinary 1Gastrointestinal 1Dermatologic 1CNS 1

Conditions

Glioblastoma 40Brain Neoplasms 34Melanoma 15Glioma 13Carcinoma, Non-Small-Cell Lung 9Gliosarcoma 7Neoplasms 6Carcinoma, Renal Cell 6Stomach Neoplasms 5Ovarian Neoplasms 4Meningioma 4Lung Neoplasms 4Esophageal Neoplasms 4Colorectal Neoplasms 4Breast Neoplasms 4Astrocytoma 4Uterine Cervical Neoplasms 3Triple Negative Breast Neoplasms 3Sarcoma 3Recurrence 3Central Nervous System Neoplasms 3Uveal Melanoma 2Turcot syndrome 2Squamous Cell Carcinoma of Head and Neck 2Small Cell Lung Carcinoma 2Parkinson Disease 4, Autosomal Dominant Lewy Body 2Pancreatic Neoplasms 2Neuroblastoma 2Neoplasms, Germ Cell and Embryonal 2Neoplasm Metastasis 2

Interventions

Cyclophosphamide 14Etoposide 12Temozolomide 10Carboplatin 9Granulocyte Colony-Stimulating Factor 8Filgrastim 8Vincristine 7etoposide phosphate 6X-Rays 6Thiotepa 6Phantoms, Imaging 6Magnetic Resonance Spectroscopy 6Cisplatin 6Topotecan 5Specimen Handling 5Radiotherapy 5Nuclear Medicine Department, Hospital 5Methotrexate 5fludarabine 4Stem Cell Transplantation 4Peripheral Blood Stem Cell Transplantation 4Mesna 4Melphalan 4Biopsy 4palbociclib 3Sirolimus 3Irinotecan 3Ifosfamide 3Busulfan 3Automobiles 3

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Rhabdoid Tumor × pembrolizumab × CNS × Clear all
NCT04483778 2026-04-28

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Seattle Children's Hospital

Phase 1 Active not recruiting
68 enrolled
CNSDermatologicGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Carcinoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

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