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Phase

Phase 1 1

Status

Recruiting 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

Sarcoma 1Genitourinary 1Gastrointestinal 1Dermatologic 1CNS 1

Conditions

Neuroblastoma 12Recurrence 3Osteosarcoma 3Neoplasm Metastasis 3Melanoma 3Brain Neoplasms 3Sarcoma 2Rhabdomyosarcoma 2Rhabdoid Tumor 2Neurofibrosarcoma 2Neuroectodermal Tumors, Primitive, Peripheral 2Lymphoma 2Leukemia, Myelomonocytic, Juvenile 2Leukemia 2Glioma 2Glioblastoma 2Desmoplastic Small Round Cell Tumor 2Breast Neoplasms 2Wilms Tumor 1Uveal Melanoma 1Thyroid Neoplasms 1Squamous Cell Carcinoma of Head and Neck 1Sarcoma, Ewing 1Sarcoma, Clear Cell 1Precursor Cell Lymphoblastic Leukemia-Lymphoma 1Pheochromocytoma 1Paraganglioma 1Neurofibromatosis 1 1Neuroendocrine Tumors 1Neuroectodermal Tumors, Primitive 1

Interventions

Cyclophosphamide 2pembrolizumab 1pegylated granulocyte colony-stimulating factor 1fludarabine phosphate 1fludarabine 1cabozantinib 1Zoledronic Acid 1Topotecan 1Sirolimus 1Simvastatin 1Radiotherapy, Image-Guided 1Mesna 1Granulocyte Colony-Stimulating Factor 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Sarcoma, Clear Cell × fludarabine phosphate × CNS × Clear all
NCT04897321 2026-05-19

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

St. Jude Children's Research Hospital

Phase 1 Recruiting
48 enrolled
CNSDermatologicGastrointestinalGenitourinarySarcoma

Adrenal Cortex Neoplasms, Carcinoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

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