Announcements Trials
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Phase

Phase 2 5Phase 1 1

Status

Terminated 2Withdrawn 1Recruiting 1Completed 1Active not recruiting 1

Sponsor Class

OTHER 4INDUSTRY 2

Study Type

Interventional 6

Sponsor

Cancer Type

Gastrointestinal 67Genitourinary 31Gynecologic 26Head & Neck 15Endocrine 12Dermatologic 11Thoracic 9Breast 8CNS 6Sarcoma 5NET 5Tumor-Agnostic 4Other solid neoplasm 3Other hematologic neoplasm 1

Conditions

Brain Neoplasms 3Neoplasms 2Carcinoma, Renal Cell 2Triple Negative Breast Neoplasms 1Stomach Neoplasms 1Parkinson Disease 4, Autosomal Dominant Lewy Body 1Pancreatic Neoplasms 1Ovarian Neoplasms 1Meningeal Carcinomatosis 1Melanoma 1Glioblastoma 1Colorectal Neoplasms 1Central Nervous System Neoplasms 1Biliary Tract Neoplasms 1

Interventions

Temozolomide 165Magnetic Resonance Spectroscopy 130Radiotherapy 95Specimen Handling 80Radiosurgery 60Cyclophosphamide 55pembrolizumab 51Bevacizumab 51Nivolumab 48Radiation 47Carboplatin 34Biopsy 33Irinotecan 29Lomustine 25Etoposide 25Vincristine 23Topotecan 23Ipilimumab 23dinutuximab 21Cisplatin 21Blood Specimen Collection 21fludarabine 19Radiotherapy, Intensity-Modulated 19X-Rays 18Surgical Procedures, Operative 18abemaciclib 16Mental Status and Dementia Tests 16Granulocyte-Macrophage Colony-Stimulating Factor 16Pemetrexed 15atezolizumab 14

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

6 trials
RecentStart dateEnrollment
lenvatinib × CNS × 1 year × Clear all
NCT04955743 2026-06-04

Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma

Yale University

Phase 2 Terminated
18 enrolled 13 charts
CNSDermatologicGenitourinary

Brain Neoplasms, Carcinoma, Renal Cell, Melanoma

NCT03797326 2026-05-04

LEAP-005

Merck Sharp & Dohme LLC

Phase 2 Completed
611 enrolled 27 charts
BreastCNSGastrointestinalGynecologic

Parkinson Disease 4, Autosomal Dominant Lewy Body, Biliary Tract Neoplasms, Glioblastoma, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT05081180 2026-05-01

Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors

EMD Serono

Phase 1 Active not recruiting
17 enrolled
CNS

Neoplasms, Central Nervous System Neoplasms

NCT05064280 2026-04-16

Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases

M.D. Anderson Cancer Center

Phase 2 Recruiting
104 enrolled
CNS

Brain Neoplasms, Neoplasms

NCT07011849 2025-08-13

Study of Lenvatinib Plus Pembrolizumab in IO Refractory mRCC Patients With Brain Metastases

M.D. Anderson Cancer Center

Phase 2 Withdrawn
CNSGenitourinary

Brain Neoplasms, Carcinoma, Renal Cell

NCT04729348 2025-07-25

Pembrolizumab And Lenvatinib In Leptomeningeal Metastases

Massachusetts General Hospital

Phase 2 Terminated
10 enrolled
CNS

Meningeal Carcinomatosis

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