Clinical Trials

Phase 1/2 Active not recruiting

Brain Neoplasms

NCT03157128 2026-04-16

LIBRETTO-001

857 enrolled 24 charts 6 FDA

BreastCNSEndocrineGastrointestinalHead & NeckThoracic

Thyroid Cancer, Papillary, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Site, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Central Nervous System Neoplasms, Carcinoma, Medullary

NCT04998864 2026-04-16

Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption in GBM Patients

Completed

3 enrolled

Glioblastoma, Glioma

NCT05317858 2026-04-16

LIMITLESS

30 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT05580562 2026-04-16

ACTION

510 enrolled

Glioma

NCT07042620 2026-04-16

A Study to Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery

Phase NA Recruiting

15 enrolled

Glioblastoma, Glioma

NCT07100730 2026-04-16

IPAX BrIGHT

50 enrolled

Brain Neoplasms, Glioblastoma, Neoplasm Recurrence, Local, Neoplasms, Central Nervous System Neoplasms

NCT07221331 2026-04-16

PRECIOUS Egypt

Recruiting

200 enrolled

Phase 2 Not yet recruiting

Neurofibromatosis 1

NCT07533942 2026-04-16

A Study of JZP3507 (ONC206) in Recurrent Grade 2 or 3 Meningioma

30 enrolled

Phase 2 Active not recruiting

Meningioma

NCT04762069 2026-04-15

A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme

252 enrolled

CNSGastrointestinalOther solid neoplasmSarcomaThoracic

Brain Neoplasms, Glioblastoma

NCT05275478 2026-04-15

Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors

Phase 1/2 Terminated

110 enrolled

Glioblastoma, Mesothelioma, Sarcoma, Cholangiocarcinoma, Neurofibrosarcoma

NCT06641908 2026-04-15

Anti-GD2 ADC M3554 in Advanced Solid Tumors

Phase 1 Recruiting

52 enrolled

CNSSarcoma

Glioblastoma, Sarcoma

NCT06805305 2026-04-14

DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM)

180 enrolled

Glioblastoma

NCT07185880 2026-04-14

STAR-GBM

36 enrolled

Glioblastoma

NCT07326566 2026-04-14

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

162 enrolled

Phase 1 Active not recruiting

Brain Neoplasms, Central Nervous System Diseases, Glioblastoma, Glioma

NCT02381886 2026-04-13

A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations

166 enrolled

CNSGastrointestinalMyeloidOther hematologic neoplasm

Astrocytoma, Glioblastoma, Glioma, Leukemia, Myelodysplastic Syndromes, Oligodendroglioma, Leukemia, Myeloid, Acute, Cholangiocarcinoma

NCT04924075 2026-04-13

MK-6482-015

322 enrolled 3 FDA

CNSEndocrine

von Hippel-Lindau Disease, Adenoma, Islet Cell, Paraganglioma, Pheochromocytoma

NCT04988750 2026-04-13

Evaluate the Safety and Preliminary Efficacy of the Combination of NaviFUS System With Re-irradiation for rGBM Patients

Phase NA Completed

7 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT06012695 2026-04-13

NBM-BMX Administered Orally to Patients With Solid Tumors or Newly Diagnosed Glioblastoma

79 enrolled

BreastCNSGastrointestinalThoracic

Brain Neoplasms, Neoplasms

NCT06253871 2026-04-13

A Phase 1/1b Study of IAM1363 in HER2 Cancers

Phase 1 Recruiting

383 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Neoplasms, Stomach Neoplasms

NCT06395103 2026-04-13

MK-9999-01A

90 enrolled

CNSLymphoidSarcoma

Burkitt Lymphoma, Neuroblastoma, Sarcoma, Ewing, Lymphoma, Large B-Cell, Diffuse

NCT06810544 2026-04-13

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

191 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Glioma, Lung Neoplasms

NCT07523529 2026-04-13

SELECT-2CAR

BreastCNSGastrointestinalGenitourinaryGynecologic

72 enrolled

Glioblastoma, Carcinoma, Hepatocellular, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Triple Negative Breast Neoplasms

NCT04446416 2026-04-09

Efficacy and Safety of NaviFUS System add-on Bevacizumab (BEV) in Recurrent GBM Patients

Phase NA Completed

6 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms, Nerve Tissue

NCT05919264 2026-04-09

FOG-001 in Locally Advanced or Metastatic Solid Tumors

CNSGastrointestinalGenitourinaryGynecologicSarcoma

595 enrolled

Craniopharyngioma, Carcinoma, Hepatocellular, Neoplasm Metastasis, Neoplasms, Adenomatous Polyposis Coli, Prostatic Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Desmoid Tumors

NCT06329570 2026-04-09

Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM)

10 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms, Nerve Tissue

NCT06496971 2026-04-09

A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients

32 enrolled

Phase 2 Active not recruiting

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms, Nerve Tissue

NCT03962543 2026-04-08

ReNeu

114 enrolled 25 charts 3 FDA

Neurofibroma, Neurofibromatosis 1, Neurofibromatoses, Neurofibroma, Plexiform

NCT04774718 2026-04-06

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors

42 enrolled

Central Nervous System Neoplasms

NCT05386108 2026-04-06

ELECTRA

73 enrolled

BreastCNS

Brain Diseases, Brain Neoplasms, Breast Diseases, Breast Neoplasms, Central Nervous System Diseases, Neoplasms, Neoplasms by Site, Central Nervous System Neoplasms

NCT06517888 2026-04-06

Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma

27 enrolled

Neuroma, Acoustic, Hearing Loss

NCT06910306 2026-04-06

Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Glioblastoma

Phase NA Recruiting

10 enrolled

Glioblastoma, Glioma

NCT07407803 2026-04-06

Evaluation of TQ-B3234 Capsules in Patients With Symptomatic, Non-Surgical Type 1 Neurofibromatosis-Associated Plexiform Neurofibromas

177 enrolled

Neurofibroma, Plexiform

NCT07503613 2026-04-06

Long Term Follow-up Study of AAVAnc80-antiVEGF Gene Therapy

Enrolling by invitation

100 enrolled

Phase 2 Active not recruiting

Neuroma, Acoustic, Hearing Loss

NCT03678883 2026-04-03

9-ING-41 in Patients With Advanced Cancers

350 enrolled

BreastCNSGastrointestinalGenitourinaryLymphoidOther hematologic neoplasmSarcomaThoracic

Bone Neoplasms, Breast Neoplasms, Glioma, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Neoplasms, Hereditary Sensory and Autonomic Neuropathies, Pancreatic Neoplasms, Sarcoma, Colorectal Neoplasms, Leukemia-Lymphoma, Adult T-Cell

NCT04724369 2026-04-03

Open-Label Study of 18F-mFBG for Imaging Neuroblastoma

Phase 3 Active not recruiting

43 enrolled

Neuroblastoma

NCT05503797 2026-04-03

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

254 enrolled

Glioma

NCT07497373 2026-04-03

JL15003

Phase 1 Completed

17 enrolled