Clinical Trials

35 enrolled

Meningioma

NCT06649058 2026-04-15

EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active

316 enrolled

Brain Neoplasms

NCT03550391 2026-04-14

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Phase 3 Recruiting

206 enrolled

Phase 1/2 Active not recruiting

Brain Neoplasms

NCT03604978 2026-04-13

Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma

38 enrolled

Meningioma

NCT05222620 2026-04-13

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

90 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT05987644 2026-04-08

DURABLE

Phase 1/2 Recruiting

56 enrolled

Brain Neoplasms, Lung Neoplasms

NCT04804644 2026-04-03

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

Phase 3 Recruiting

200 enrolled

Brain Neoplasms, Lung Neoplasms, Small Cell Lung Carcinoma

NCT05438212 2026-04-03

Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases

237 enrolled

BreastCNSDermatologicGenitourinaryThoracic

Brain Neoplasms

NCT06500455 2026-04-03

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

Phase 3 Recruiting

269 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT03508752 2026-03-27

Neurocognitive Decline in Patients With Brain Metastases

Phase 1/2 Active not recruiting

80 enrolled

Brain Neoplasms

NCT04074096 2026-03-25

BEPCOME-MB

10 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT04545814 2026-03-24

Analyzing Preoperative Stereotactic Radiosurgery With Gamma Knife Icon for Brain Metastases

Phase NA Completed

11 enrolled 11 charts

Brain Neoplasms

NCT05702749 2026-03-24

VS PREHAB

Phase NA Recruiting

36 enrolled

Neuroma, Acoustic

NCT04899908 2026-03-19

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

BreastCNSDermatologicGastrointestinalThoracic

134 enrolled

Brain Neoplasms, Breast Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Colorectal Neoplasms

NCT01592968 2026-03-09

Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases

88 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Neoplasm Metastasis

NCT02858869 2026-03-09

Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases

Phase 1 Completed

25 enrolled 14 charts

CNSDermatologicThoracic

Uveal Melanoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT07454668 2026-03-06

Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases

20 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT01644591 2026-03-05

Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases

49 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT04516070 2026-03-05

Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis

55 enrolled

Brain Neoplasms, Lung Neoplasms, Small Cell Lung Carcinoma

NCT03368625 2026-03-04

NASRS

Phase NA Completed

30 enrolled

Brain Neoplasms

NCT05789589 2026-03-04

ADORATION

Phase 1/2 Recruiting

46 enrolled

Phase NA Not yet recruiting

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT07437820 2026-03-04

NeoSRS

68 enrolled

Brain Neoplasms

NCT06315296 2026-03-03

An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer

Phase NA Terminated

1 enrolled

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms

NCT07429422 2026-02-24

SBRT Technique Implementation for Spinal Metastases Irradiation

Phase NA Recruiting

100 enrolled

Spinal Cord Neoplasms

NCT00950001 2026-02-20

Stereotactic Radiosurgery Compared to Observation in Treating Patients With Brain Metastases

132 enrolled

Brain Neoplasms

NCT05419076 2026-02-11

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

62 enrolled

Brain Neoplasms, Lung Neoplasms, Small Cell Lung Carcinoma

NCT04923542 2026-02-06

Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases

Phase 1/2 Recruiting

31 enrolled

Brain Neoplasms

NCT03340129 2026-02-02

ABC-X

218 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT05102747 2026-01-27

OligoBM-01

Phase NA Recruiting

504 enrolled

Brain Neoplasms

NCT04114981 2026-01-26

Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease

242 enrolled