Announcements Trials
Browse Landscape

Phase

Phase 2 11Phase 1/2 5Phase 1 4Phase 3 1

Status

Active not recruiting 3Not yet recruiting 1Completed 1

Sponsor Class

OTHER 2NIH 2INDUSTRY 1

Study Type

Interventional 5

Sponsor

Cancer Type

CNS 5Thoracic 3Gastrointestinal 3Sarcoma 2Tumor-Agnostic 1Other hematologic neoplasm 1Lymphoid 1Breast 1

Conditions

Neurofibromatosis 1 5Neurofibroma, Plexiform 2Pain 1Optic Nerve Glioma 1Neurofibrosarcoma 1Astrocytoma 1

Interventions

Temozolomide 102Radiotherapy 47Bevacizumab 33Carboplatin 23Irinotecan 20pembrolizumab 17Radiosurgery 16Nivolumab 16Radiation 14Cyclophosphamide 11Magnetic Resonance Spectroscopy 10fludarabine 8Trastuzumab 8Radiotherapy, Intensity-Modulated 8Carmustine 8Surgical Procedures, Operative 7Specimen Handling 7Pemetrexed 7Paclitaxel 7Interleukin-2 7Filgrastim 7Everolimus 7Erlotinib Hydrochloride 7temsirolimus 6Vorinostat 6Radiotherapy, Conformal 6Lomustine 6Ipilimumab 6Granulocyte-Macrophage Colony-Stimulating Factor 6Gemcitabine 6

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Phase 1/2 × AZD 6244 × CNS × Clear all
NCT05309668 2026-06-09

SPRINKLE

AstraZeneca

Phase 1/2 Active not recruiting
36 enrolled 37 charts
CNS

Neurofibromatosis 1

NCT01362803 2026-06-01

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

National Institutes of Health Clinical Center (CC)

Phase 1/2 Active not recruiting
99 enrolled 1 FDA
CNS

Neurofibromatosis 1, Pain, Neurofibroma, Plexiform

NCT01089101 2026-05-13

Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma

National Cancer Institute (NCI)

Phase 1/2 Active not recruiting
217 enrolled
CNS

Astrocytoma, Neurofibromatosis 1

NCT06735820 2025-07-03

MEKMDM2

Children's National Research Institute

Phase 1/2 Not yet recruiting
45 enrolled
CNSSarcoma

Neurofibromatosis 1, Neurofibrosarcoma

NCT03326388 2024-04-04

INSPECT

Great Ormond Street Hospital for Children NHS Foundation Trust

Phase 1/2 Completed
14 enrolled
CNS

Neurofibromatosis 1, Neurofibroma, Plexiform, Optic Nerve Glioma

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