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Phase

Phase 2 2Phase 1/2 1Phase 1 1

Status

Active not recruiting 7Not yet recruiting 6Completed 4Withdrawn 2Terminated 1Recruiting 1Approved for marketing 1

Sponsor Class

OTHER 2NIH 1INDUSTRY 1

Study Type

Interventional 4

Sponsor

Cancer Type

Thoracic 19Gastrointestinal 14Dermatologic 10Other solid neoplasm 7CNS 4Breast 4Tumor-Agnostic 3Head & Neck 3Sarcoma 2Endocrine 2Plasma cell 1Other hematologic neoplasm 1Myeloid 1Lymphoid 1Gynecologic 1Genitourinary 1

Conditions

Neurofibromatosis 1 3Optic Nerve Glioma 1Neurofibrosarcoma 1Neurofibroma, Plexiform 1Neuroblastoma 1Lymphoma, Non-Hodgkin 1Central Nervous System Neoplasms 1

Interventions

Temozolomide 299Radiotherapy 219Bevacizumab 139Carboplatin 91Cyclophosphamide 88Etoposide 82Filgrastim 72Vincristine 69Irinotecan 69Magnetic Resonance Spectroscopy 65Cisplatin 59Radiation 58Radiosurgery 53Surgical Procedures, Operative 41Peripheral Blood Stem Cell Transplantation 40Topotecan 39Doxorubicin 39Lomustine 37Carmustine 36sargramostim 35Granulocyte Colony-Stimulating Factor 35Melphalan 34Nivolumab 32Chemotherapy, Adjuvant 32Radiotherapy, Intensity-Modulated 29Isotretinoin 29Everolimus 29Erlotinib Hydrochloride 27Thiotepa 25Vorinostat 24

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Completed × AZD 6244 × CNS × Clear all
NCT03433183 2026-05-27

SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

Sarcoma Alliance for Research through Collaboration

Phase 2 Completed
21 enrolled 12 charts
CNSSarcoma

Neurofibromatosis 1, Neurofibrosarcoma

NCT03213691 2025-02-05

Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

National Cancer Institute (NCI)

Phase 2 Completed
21 enrolled 11 charts
CNSLymphoid

Lymphoma, Non-Hodgkin, Neuroblastoma, Central Nervous System Neoplasms

NCT03326388 2024-04-04

INSPECT

Great Ormond Street Hospital for Children NHS Foundation Trust

Phase 1/2 Completed
14 enrolled
CNS

Neurofibromatosis 1, Neurofibroma, Plexiform, Optic Nerve Glioma

NCT04495127 2023-04-26

Selumetinib Paediatric NF1 Japan Study

AstraZeneca

Phase 1 Completed
12 enrolled
CNS

Neurofibromatosis 1

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