Clinical Trials

153 enrolled 12 charts

Phase 2 Active not recruiting

Neuroblastoma

NCT03786783 2026-04-13

Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

42 enrolled 12 charts

Ganglioneuroblastoma

NCT02595905 2026-04-08

Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases

344 enrolled 11 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms, Triple Negative Breast Neoplasms

NCT03126916 2026-02-27

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Phase 3 Recruiting

750 enrolled

Phase EARLY_PHASE1 Recruiting

Neuroblastoma, Ganglioneuroblastoma

NCT06942039 2026-02-27

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

15 enrolled

Phase 4 Active not recruiting

Medulloblastoma, Neuroblastoma, Pinealoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

NCT02875314 2026-02-12

HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors

250 enrolled

Medulloblastoma

NCT05535166 2026-02-12

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

Phase 2 Recruiting

130 enrolled

Brain Neoplasms, Medulloblastoma

NCT00336024 2026-01-23

Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma

91 enrolled 24 charts

Medulloblastoma

NCT01175356 2026-01-23

Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin

99 enrolled 11 charts

Phase 2/3 Active not recruiting

Neuroblastoma, Ganglioneuroblastoma

NCT04711824 2025-12-23

SOLARA

Phase 1/2 Recruiting

41 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT02066220 2025-12-04

International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma

360 enrolled

Phase 2 Active not recruiting

Brain Neoplasms, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT01878617 2025-11-13

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

660 enrolled

Brain Neoplasms, Medulloblastoma, Infratentorial Neoplasms, Neuroectodermal Tumors, Primitive

NCT04402073 2025-10-23

PersoMed-I

Phase 2 Terminated

20 enrolled

Phase 2 Not yet recruiting

Medulloblastoma

NCT07138001 2025-08-22

Phase 2 Clinical Trial of KH617

60 enrolled

Phase 3 Active not recruiting

Glioblastoma

NCT00392327 2025-06-13

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET

379 enrolled 29 charts

Medulloblastoma

NCT03274414 2025-05-16

A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages

3 enrolled 4 charts

Adenocarcinoma, Carcinoma, Squamous Cell, Carcinoma, Adenoid Cystic, Paranasal Sinus Neoplasms, Esthesioneuroblastoma, Olfactory

NCT00085735 2025-01-14

Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma

549 enrolled 32 charts

Medulloblastoma

NCT01798004 2024-07-15

Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

150 enrolled 9 charts

Neuroblastoma, Ganglioneuroblastoma

NCT00085202 2024-02-08

Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

416 enrolled 16 charts

Central Nervous System Neoplasms, Rhabdoid Tumor

NCT03684811 2023-11-18

A Study of FT-2102 in Patients With Advanced Solid Tumors and Gliomas With an IDH1 Mutation

Phase 1/2 Completed

93 enrolled 24 charts

CNSGastrointestinal

Bile Duct Neoplasms, Glioblastoma, Carcinoma, Hepatocellular, Cholangiocarcinoma

NCT00003309 2023-06-22

Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer

33 enrolled

CNSGenitourinaryGynecologic

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms

NCT04851834 2022-12-20

NTX-301 Monotherapy in Advanced Solid Tumours and in Combination With Platinum-based Chemotherapy in Advanced Ovarian & Bladder Cancer and in Combination With Temozolomide in High-grade Glioma

Phase 1/2 Terminated

12 enrolled

Urinary Bladder Neoplasms, Glioma, Ovarian Neoplasms

NCT00567567 2022-04-28

Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma

665 enrolled 26 charts

Neuroblastoma

NCT00867178 2022-01-13

Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System

33 enrolled

Phase EARLY_PHASE1 Terminated

Medulloblastoma, Pinealoma

NCT02212574 2021-11-05

Study Assessing the Feasibility of a Surgery and Chemotherapy-Only in Children With Wnt Positive Medulloblastoma

6 enrolled 6 charts

Medulloblastoma

NCT02185352 2021-05-07

A-Plus

Phase 2 Unknown

120 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT01704716 2020-10-23

High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)

Phase 3 Recruiting

3,300 enrolled

Neuroblastoma

NCT00498979 2020-07-24

Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers

22 enrolled

CNSDermatologicSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Melanoma, Oligodendroglioma, Glioma, Subependymal, Gliosarcoma

NCT00058370 2020-05-11

Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma

Phase NA Completed

6 enrolled 8 charts

Medulloblastoma, Central Nervous System Neoplasms

NCT00006036 2020-04-06

Liposomal Lurtotecan Plus Cisplatin in Treating Patients With Advanced or Metastatic Solid Tumors

CNSGynecologicHead & NeckThoracic

14 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Lung Neoplasms, Nasopharyngeal Neoplasms, Ovarian Neoplasms, Esthesioneuroblastoma, Olfactory, Small Cell Lung Carcinoma

NCT01614132 2020-03-31

NOA-07

Phase 1/2 Completed

33 enrolled

Medulloblastoma, Neoplasms, Neuroectodermal Tumors

NCT00578864 2020-03-27

PEPI

13 enrolled 7 charts

Neuroblastoma

NCT02786719 2020-03-12

SPRING

Phase NA Completed

13 enrolled 13 charts

Neuroblastoma

NCT01014767 2019-08-20

Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors

Phase 3 Terminated

27 enrolled 1 chart

Brain Neoplasms, Choroid Plexus Neoplasms

NCT00031590 2019-04-25

Low-Dose Radiation and Combination Chemotherapy Following Surgery in Children With Newly Diagnosed Medulloblastoma

Phase 2 Terminated

30 enrolled 5 charts

Brain Neoplasms, Medulloblastoma, Central Nervous System Neoplasms

NCT00085098 2018-09-07

Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor

24 enrolled 9 charts

Brain Neoplasms, Central Nervous System Neoplasms

NCT00470366 2017-11-28

Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors