Announcements Trials
Browse Landscape

Phase

Phase 1 4Phase 1/2 2Phase 2 1

Status

Withdrawn 2Terminated 2Unknown 1Recruiting 1Active not recruiting 1

Sponsor Class

OTHER 7INDUSTRY 2

Study Type

Interventional 7

Sponsor

Cancer Type

Lymphoid 64Other hematologic neoplasm 34Gastrointestinal 10Plasma cell 7CNS 7Thoracic 3Sarcoma 3Other solid neoplasm 3Head & Neck 3Gynecologic 3Breast 3Dermatologic 2Myeloid 1Genitourinary 1Classical hematology 1

Conditions

Glioma 3Glioblastoma 2Brain Neoplasms 2Sarcoma, Ewing 1Rhabdomyosarcoma 1Recurrence 1Osteosarcoma 1Neuroblastoma 1Neoplasms 1Meningeal Carcinomatosis 1Lymphoma, Follicular 1Gliosarcoma 1Central Nervous System Neoplasms 1Breast Neoplasms 1Astrocytoma 1

Interventions

Temozolomide 400Radiotherapy 239Bevacizumab 185Magnetic Resonance Spectroscopy 168Radiosurgery 142Cyclophosphamide 95Irinotecan 79Carboplatin 79Etoposide 78Radiation 76pembrolizumab 70Nivolumab 59Surgical Procedures, Operative 57Filgrastim 56Specimen Handling 53Cisplatin 50Blood Specimen Collection 46Topotecan 45Vincristine 43Melphalan 38Radiotherapy, Intensity-Modulated 36Pemetrexed 36Lomustine 36Ipilimumab 36Everolimus 35Magnetic Resonance Imaging 34Erlotinib Hydrochloride 34Drug Therapy 34Surveys and Questionnaires 33sargramostim 30

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

7 trials
RecentStart dateEnrollment
OTHER × Immunotherapy, Adoptive × CNS × Clear all
NCT03696030 2026-04-23

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

City of Hope Medical Center

Phase 1 Active not recruiting
24 enrolled
BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasms, Meningeal Carcinomatosis

NCT06815029 2025-06-26

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

City of Hope Medical Center

Phase 1 Recruiting
27 enrolled
CNSLymphoid

Astrocytoma, Glioblastoma, Lymphoma, Follicular

NCT02100891 2025-03-19

STIR

Medical College of Wisconsin

Phase 2 Terminated
15 enrolled 11 charts
CNSSarcoma

Brain Neoplasms, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Central Nervous System Neoplasms

NCT02664363 2023-02-17

ExCeL

Duke University

Phase 1 Terminated
3 enrolled 8 charts
CNSSarcoma

Glioblastoma, Gliosarcoma

NCT03423992 2021-06-15

Personalized Chimeric Antigen Receptor T Cell Immunotherapy for Patients With Recurrent Malignant Gliomas

Xuanwu Hospital, Beijing

Phase 1 Unknown
100 enrolled
CNS

Glioma, Recurrence

NCT02575261 2020-07-16

CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients

Fuda Cancer Hospital, Guangzhou

Phase 1/2 Withdrawn
CNS

Glioma

NCT03252171 2020-07-16

CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients

Fuda Cancer Hospital, Guangzhou

Phase 1/2 Withdrawn
CNS

Glioma

Data powered by HemOnc (CC BY 4.0) Colophon âš¡