Clinical Trials Browser

Leucovorin × CNS × Clear all

NCT05355701 2026-05-14

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Phase 1 Recruiting

267 enrolled

CNSDermatologicHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Thyroid Neoplasms

NCT05919264 2026-05-12

FOG-001 in Locally Advanced or Metastatic Solid Tumors

Phase 1/2 Recruiting

595 enrolled

CNSGastrointestinalGenitourinaryGynecologicSarcoma

Craniopharyngioma, Carcinoma, Hepatocellular, Neoplasm Metastasis, Neoplasms, Adenomatous Polyposis Coli, Prostatic Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Desmoid Tumors

NCT00336024 2026-01-23

Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma

Phase 3 Completed

91 enrolled 24 charts

CNS

Medulloblastoma

NCT00082797 2023-06-15

High-Dose Methotrexate and Leucovorin in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Phase 2 Completed

36 enrolled

CNSSarcoma

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00000723 2021-10-28

The Use of Chemotherapy Plus Radiotherapy Plus Azidothymidine in Patients With AIDS-Related Lymph Node Cancer

Phase NA Terminated

45 enrolled

CNSLymphoid

Acquired Immunodeficiency Syndrome, Brain Neoplasms, Lymphoma, Lymphoma, Non-Hodgkin, HIV Infections, AIDS-Related Opportunistic Infections

NCT02015819 2021-10-20

Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas

Phase 1 Completed

16 enrolled 16 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT01014767 2019-08-20

Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors

Phase 3 Terminated

27 enrolled 1 chart

CNS

Brain Neoplasms, Choroid Plexus Neoplasms

NCT03607643 2018-07-31

A Study of the Efficacy of Cannabidiol in Patients With Multiple Myeloma, Glioblastoma Multiforme, and GI Malignancies

Phase 1/2 Unknown

160 enrolled

CNSGastrointestinalPlasma cell

Colonic Neoplasms, Gallbladder Neoplasms, Glioblastoma, Liver Neoplasms, Multiple Myeloma, Pancreatic Neoplasms, Rectal Neoplasms

NCT01737671 2018-01-19

Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study

Phase EARLY_PHASE1 Completed

7 enrolled

CNS

Brain Neoplasms, Ependymoma, Medulloblastoma, Rhabdoid Tumor

NCT01183663 2016-06-03

Lenalidomide in Combination With Bevacizumab, Sorafenib, Temsirolimus, or 5-Fluorouracil, Leucovorin, Oxaliplatin (FOLFOX)

Phase 1 Completed

180 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryOther hematologic neoplasmPlasma cell

Breast Neoplasms, Carcinoma, Renal Cell, Colonic Neoplasms, Glioblastoma, Melanoma, Multiple Myeloma, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms

NCT00084838 2015-12-24

Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT

Phase 2 Completed

25 enrolled 24 charts

CNS

Central Nervous System Neoplasms, Rhabdoid Tumor

NCT00003273 2015-12-03

Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Phase 2 Withdrawn

CNSOther solid neoplasmSarcoma

Neuroblastoma, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms

NCT00416819 2015-08-20

Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Primary CNS Lymphoma

Phase NA Completed

10 enrolled

CNSLymphoid

Lymphoma, Central Nervous System Neoplasms

NCT00513981 2013-06-26

High-Dose Methotrexate in Treating Young Patients With Solid Tumors

Phase 1 Completed

36 enrolled

CNSSarcoma

Familial ependymoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms

NCT00281944 2013-05-03

Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors

Phase 1 Completed

42 enrolled

CNSOther solid neoplasm

Childhood Central Nervous System Choriocarcinoma

NCT00002463 2013-02-18

Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors

Phase 2 Completed

4 enrolled

CNS

Astrocytoma, Central Nervous System Neoplasms

NCT00005860 2011-04-26

Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum

Phase 1 Completed

CNSEndocrineGastrointestinalGynecologicSarcoma

Appendiceal Neoplasms, Bile Duct Neoplasms, Colonic Neoplasms, Vipoma, Fallopian Tube Neoplasms, Gallbladder Neoplasms, Glucagonoma, Carcinoma, Hepatocellular, Insulinoma, Neoplasms, Neoplasms, Unknown Primary, Neuroblastoma, Pancreatic Neoplasms, Pheochromocytoma, Pseudomyxoma Peritonei, Somatostatinoma, Stomach Neoplasms, Gastrinoma, Carcinoma, Islet Cell, Gastrointestinal Stromal Tumors