Announcements Trials
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Phase

Phase 2 16Phase NA 5Phase 3 5Phase 1 4Phase EARLY_PHASE1 3Phase 4 3Phase 1/2 2

Status

Completed 3Withdrawn 1

Sponsor Class

OTHER 2NIH 2

Study Type

Interventional 4

Sponsor

Cancer Type

Other hematologic neoplasm 40Lymphoid 38Myeloid 11Sarcoma 7Plasma cell 6CNS 4Breast 3Dermatologic 2

Conditions

Sarcoma 2Central Nervous System Neoplasms 2Osteosarcoma 1Neuroectodermal Tumors, Primitive, Peripheral 1Neuroblastoma 1Medulloblastoma 1Familial ependymoma 1Ependymoma 1Brain Neoplasms 1

Interventions

Temozolomide 147Radiotherapy 90Cyclophosphamide 53Magnetic Resonance Spectroscopy 42Radiation 41Bevacizumab 38Irinotecan 34Filgrastim 29Radiosurgery 26Specimen Handling 25Nivolumab 25Carboplatin 24Topotecan 23Etoposide 22fludarabine 20Surgical Procedures, Operative 20pembrolizumab 18Vorinostat 18Vincristine 18Melphalan 17Granulocyte Colony-Stimulating Factor 17sargramostim 15Peripheral Blood Stem Cell Transplantation 14Ipilimumab 14Drug Therapy 13temsirolimus 12Sirolimus 12Radiotherapy, Intensity-Modulated 12O(6)-benzylguanine 12Everolimus 12

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Phase 1 × Methotrexate × CNS × Clear all
NCT06466798 2026-01-08

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

The University of Texas Health Science Center, Houston

Phase 1 Withdrawn
CNS

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms

NCT02458339 2019-03-06

Methotrexate Infusion Into Fourth Ventricle in Children With Recurrent Malignant Fourth Ventricular Brain Tumors

The University of Texas Health Science Center, Houston

Phase 1 Completed
7 enrolled
CNS

Brain Neoplasms

NCT00112645 2013-07-18

Donor Stem Cell Transplant in Treating Young Patients With Relapsed or Refractory Solid Tumors

National Cancer Institute (NCI)

Phase 1 Completed
10 enrolled
CNSSarcoma

Neuroblastoma, Sarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT00513981 2013-06-26

High-Dose Methotrexate in Treating Young Patients With Solid Tumors

National Cancer Institute (NCI)

Phase 1 Completed
36 enrolled
CNSSarcoma

Familial ependymoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms

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