Clinical Trials Browser

Burkitt Lymphoma, Hodgkin Disease, Immunoblastic Lymphadenopathy, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Central Nervous System Neoplasms, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Intraocular Lymphoma

NCT00030264 2018-08-08

Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform Neurofibromas

Phase 2 Completed

23 enrolled 9 charts

CNSOther neoplasm

Neurofibromatosis 1, Precancerous Conditions, Neurofibroma, Plexiform

NCT00068250 2018-02-07

Combination Chemotherapy, Monoclonal Antibody, and Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma

Phase 1/2 Completed

60 enrolled 10 charts

CNSLymphoid

Lymphoma, Central Nervous System Neoplasms

NCT01737671 2018-01-19

Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study

Phase EARLY_PHASE1 Completed

7 enrolled

CNS

Brain Neoplasms, Ependymoma, Medulloblastoma, Rhabdoid Tumor

NCT00992602 2017-07-07

Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer

Phase 2 Completed

3 enrolled 8 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT00397501 2017-04-21

BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain

Phase 1/2 Withdrawn

BreastCNS

Brain Neoplasms, Breast Neoplasms, Central Nervous System Neoplasms, Drug-Related Side Effects and Adverse Reactions

NCT02590510 2016-10-28

Different Dose of Methotrexate for the Treatment of Meningeal Carcinomatosis

Phase 4 Unknown

50 enrolled

CNS

Meningeal Carcinomatosis

NCT00084838 2015-12-24

Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT

Phase 2 Completed

25 enrolled 24 charts

CNS

Central Nervous System Neoplasms, Rhabdoid Tumor

NCT00003273 2015-12-03

Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Phase 2 Withdrawn

CNSOther solid neoplasmSarcoma

Neuroblastoma, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms

NCT00416819 2015-08-20

Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Primary CNS Lymphoma

Phase NA Completed

10 enrolled

CNSLymphoid

Lymphoma, Central Nervous System Neoplasms

NCT00303810 2014-01-28

Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma

Phase NA Completed

567 enrolled

CNS

Central Nervous System Neoplasms

NCT00278278 2013-12-19

Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas

Phase 3 Unknown

150 enrolled

CNS

Astrocytoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT00392886 2013-12-18

Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors

Phase 3 Unknown

120 enrolled

CNS

Astrocytoma, Oligodendroglioma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT01281696 2013-10-16

Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis

Phase 2 Completed

40 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT00281905 2013-09-20

Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors

Phase 2 Unknown

50 enrolled

CNS

Astrocytoma, Neuroblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms

NCT00287924 2013-09-17

High-Dose Methotrexate in Treating Young Patients With Residual Ependymoma

Phase 2 Unknown

29 enrolled

CNS

Central Nervous System Neoplasms

NCT00006258 2013-07-18

Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma

Phase 2 Completed

CNS

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive

NCT00112645 2013-07-18

Donor Stem Cell Transplant in Treating Young Patients With Relapsed or Refractory Solid Tumors

Phase 1 Completed

10 enrolled

CNSSarcoma

Neuroblastoma, Sarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT00513981 2013-06-26

High-Dose Methotrexate in Treating Young Patients With Solid Tumors

Phase 1 Completed

36 enrolled

CNSSarcoma

Familial ependymoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms

NCT00463008 2013-06-24

Pharmacologic Study of Methotrexate in Patients Undergoing Stereotactic Biopsy for Recurrent High-Grade Glioma

Phase NA Completed

12 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00002463 2013-02-18

Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors

Phase 2 Completed

4 enrolled

CNS

Astrocytoma, Central Nervous System Neoplasms

NCT01438021 2012-11-09

Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease

Phase NA Withdrawn

CNS

Meningeal Carcinomatosis

NCT00734773 2012-05-18

Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL

Phase EARLY_PHASE1 Withdrawn

CNSLymphoid

Lymphoma, Central Nervous System Neoplasms, Neurotoxicity Syndromes

Clinical Trials

HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma

Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children with Recurrent Posterior Fossa Brain Tumors

Regorafenib and Methotrexate in Treating Participants With Recurrent or Metastatic KRAS Mutated Non-Small Cell Lung Cancer

High-Dose Methotrexate and Leucovorin in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

ANGLeD

Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic Medulloblastoma

Allogeneic Hematopoietic Stem Cell Transplantation for 4/M Neuroblastoma

The Use of Chemotherapy Plus Radiotherapy Plus Azidothymidine in Patients With AIDS-Related Lymph Node Cancer

Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis

Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors

Methotrexate Infusion Into Fourth Ventricle in Children With Recurrent Malignant Fourth Ventricular Brain Tumors

Vaccine Therapy and GM-CSF in Treating Patients With CNS Lymphoma

Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform Neurofibromas

Combination Chemotherapy, Monoclonal Antibody, and Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma

Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study

Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer

BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain

Different Dose of Methotrexate for the Treatment of Meningeal Carcinomatosis

Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT

Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Primary CNS Lymphoma

Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma

Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas

Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors

Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis

Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors

High-Dose Methotrexate in Treating Young Patients With Residual Ependymoma

Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma

Donor Stem Cell Transplant in Treating Young Patients With Relapsed or Refractory Solid Tumors

High-Dose Methotrexate in Treating Young Patients With Solid Tumors

Pharmacologic Study of Methotrexate in Patients Undergoing Stereotactic Biopsy for Recurrent High-Grade Glioma

Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors

Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease

Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL