Clinical Trials

35 enrolled

Meningioma

NCT06649058 2026-04-15

EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active

316 enrolled

Brain Neoplasms

NCT03550391 2026-04-14

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

206 enrolled

Phase 1/2 Active not recruiting

Brain Neoplasms

NCT03604978 2026-04-13

Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma

38 enrolled

Meningioma

NCT05222620 2026-04-13

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

90 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT05987644 2026-04-08

DURABLE

56 enrolled

Brain Neoplasms, Lung Neoplasms

NCT04804644 2026-04-03

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

200 enrolled

Brain Neoplasms, Lung Neoplasms, Small Cell Lung Carcinoma

NCT05438212 2026-04-03

Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases

237 enrolled

Brain Neoplasms

NCT06500455 2026-04-03

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

BreastCNSDermatologicGenitourinaryThoracic

269 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT03508752 2026-03-27

Neurocognitive Decline in Patients With Brain Metastases

Phase 1/2 Active not recruiting

80 enrolled

Brain Neoplasms

NCT04074096 2026-03-25

BEPCOME-MB

10 enrolled

Brain Neoplasms, Melanoma

NCT04545814 2026-03-24

Analyzing Preoperative Stereotactic Radiosurgery With Gamma Knife Icon for Brain Metastases

Phase NA Completed

11 enrolled 11 charts

Brain Neoplasms

NCT05702749 2026-03-24

VS PREHAB

Phase NA Recruiting

36 enrolled

Neuroma, Acoustic

NCT04899908 2026-03-19

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

BreastCNSDermatologicGastrointestinalThoracic

134 enrolled

Brain Neoplasms, Breast Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Colorectal Neoplasms

NCT01592968 2026-03-09

Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases

88 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Neoplasm Metastasis

NCT02858869 2026-03-09

Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases

Phase 1 Completed

25 enrolled 14 charts

CNSDermatologicThoracic

Uveal Melanoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT07454668 2026-03-06

Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases

20 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT01644591 2026-03-05

Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases

49 enrolled

Brain Neoplasms, Melanoma

NCT04516070 2026-03-05

Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis

55 enrolled

Brain Neoplasms, Lung Neoplasms, Small Cell Lung Carcinoma

NCT03368625 2026-03-04

NASRS

Phase NA Completed

30 enrolled

Brain Neoplasms

NCT05789589 2026-03-04

ADORATION

46 enrolled

Phase NA Not yet recruiting

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT07437820 2026-03-04

NeoSRS

68 enrolled

Brain Neoplasms

NCT06315296 2026-03-03

An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer

Phase NA Terminated

1 enrolled

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms

NCT07429422 2026-02-24

SBRT Technique Implementation for Spinal Metastases Irradiation

Phase NA Recruiting

100 enrolled

Spinal Cord Neoplasms

NCT00950001 2026-02-20

Stereotactic Radiosurgery Compared to Observation in Treating Patients With Brain Metastases

132 enrolled

Brain Neoplasms

NCT05419076 2026-02-11

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

62 enrolled

Brain Neoplasms, Lung Neoplasms, Small Cell Lung Carcinoma

NCT04923542 2026-02-06

Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases

31 enrolled

Brain Neoplasms

NCT03340129 2026-02-02

ABC-X

218 enrolled

Brain Neoplasms, Melanoma

NCT05102747 2026-01-27

OligoBM-01

Phase NA Recruiting

504 enrolled

Brain Neoplasms

NCT04114981 2026-01-26

Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease

242 enrolled

Brain Neoplasms

NCT02747303 2025-12-29

Frameless Stereotactic Radiosurgery for Intact Brain Metastases

166 enrolled

Brain Neoplasms

NCT04474353 2025-12-26

Study of Tumor Treating Fields With Hypofractionated Chemoradiotherapy in Newly Diagnosed Glioblastoma

Phase 1 Completed

12 enrolled

Glioblastoma

NCT07304739 2025-12-26

Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases

30 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT03750227 2025-12-24

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

140 enrolled

Brain Neoplasms

NCT04711824 2025-12-23

SOLARA

41 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT03807765 2025-12-04

Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases

Phase 1 Completed

14 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT05030298 2025-11-21

Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial

Phase 1 Recruiting

28 enrolled

Glioma

NCT06132945 2025-11-14

A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain

Phase 1/2 Active not recruiting

2 enrolled

CNSGenitourinary

Brain Neoplasms, Carcinoma, Renal Cell

NCT02696993 2025-11-10

Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer

80 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT04365374 2025-10-07

Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)

230 enrolled

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT05270707 2025-09-24

HyperArc Registry Study

Completed

968 enrolled

Brain Diseases, Brain Neoplasms, Central Nervous System Neoplasms

NCT06020066 2025-09-15

SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI

202 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT03961971 2025-09-10

Trial of Anti-Tim-3 in Combination With Anti-PD-1 and SRS in Recurrent GBM

16 enrolled

Glioblastoma

NCT03741673 2025-09-05

Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases

180 enrolled

Brain Neoplasms, Neoplasms

NCT04977375 2025-09-03

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

10 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT04225039 2025-08-15

Anti-GITR/Anti-PD1/Stereotactic Radiosurgery, in Recurrent Glioblastoma

39 enrolled 10 charts

Glioblastoma

NCT05341349 2025-07-30

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases

1 enrolled

Uveal Melanoma, Brain Neoplasms, Melanoma

NCT01843413 2025-07-20

Stereotactic Radiosurgery in Treating Patients With Large Brain Metastases

33 enrolled

Brain Neoplasms

NCT04474925 2025-07-18

Pre- Versus Post-operative SRS for Resectable Brain Metastases

Phase 3 Terminated

8 enrolled