Announcements Trials
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Phase

Phase 1 4Phase 3 1Phase 2 1Phase 1/2 1

Status

Completed 3Recruiting 1

Sponsor Class

INDUSTRY 3OTHER 1

Study Type

Interventional 4

Sponsor

Cancer Type

CNS 4Thoracic 2Other solid neoplasm 1Gynecologic 1Gastrointestinal 1Breast 1

Conditions

Glioma 3Glioblastoma 3Astrocytoma 2Ependymoma 1Brain Neoplasms 1

Interventions

Temozolomide 147Radiotherapy 90Cyclophosphamide 53Magnetic Resonance Spectroscopy 42Radiation 41Bevacizumab 38Irinotecan 34Filgrastim 29Radiosurgery 26Specimen Handling 25Nivolumab 25Carboplatin 24Topotecan 23Etoposide 22fludarabine 20Surgical Procedures, Operative 20pembrolizumab 18Vorinostat 18Vincristine 18Melphalan 17Granulocyte Colony-Stimulating Factor 17sargramostim 15Peripheral Blood Stem Cell Transplantation 14Ipilimumab 14Drug Therapy 13temsirolimus 12Sirolimus 12Radiotherapy, Intensity-Modulated 12O(6)-benzylguanine 12Everolimus 12

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Phase 1 × Valacyclovir × CNS × Clear all
NCT06914479 2026-05-27

Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors

University of Michigan Rogel Cancer Center

Phase 1 Recruiting
11 enrolled
CNS

Brain Neoplasms

NCT03576612 2025-02-14

GMCI

Candel Therapeutics, Inc.

Phase 1 Completed
41 enrolled
CNS

Glioblastoma, Glioma

NCT00634231 2023-08-25

A Phase I Study of AdV-tk + Prodrug Therapy in Combination With Radiation Therapy for Pediatric Brain Tumors

Candel Therapeutics, Inc.

Phase 1 Completed
8 enrolled
CNS

Astrocytoma, Ependymoma, Glioblastoma, Glioma

NCT00751270 2023-08-25

BrTK01

Candel Therapeutics, Inc.

Phase 1 Completed
15 enrolled
CNS

Astrocytoma, Glioblastoma, Glioma

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