Announcements Trials
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Phase

Phase 2 5Phase 1/2 1

Status

Recruiting 3Withdrawn 1Unknown 1Active not recruiting 1

Sponsor Class

OTHER 6INDUSTRY 1

Study Type

Interventional 6

Sponsor

Cancer Type

Breast 24Gastrointestinal 6CNS 6Tumor-Agnostic 3Genitourinary 3Other hematologic neoplasm 2Lymphoid 2Sarcoma 1Plasma cell 1Other solid neoplasm 1Myeloid 1Gynecologic 1Classical hematology 1

Conditions

Brain Neoplasms 3Breast Neoplasms 2Recurrence 1Neuroma, Acoustic 1Neurofibromatosis 2 1Meningioma 1Lymphoma 1Leukemia 1Glioblastoma 1Ependymoma 1Disease 1Central Nervous System Neoplasms 1

Interventions

Temozolomide 400Radiotherapy 239Bevacizumab 185Magnetic Resonance Spectroscopy 168Radiosurgery 142Cyclophosphamide 95Irinotecan 79Carboplatin 79Etoposide 78Radiation 76pembrolizumab 70Nivolumab 59Surgical Procedures, Operative 57Filgrastim 56Specimen Handling 53Cisplatin 50Blood Specimen Collection 46Topotecan 45Vincristine 43Melphalan 38Radiotherapy, Intensity-Modulated 36Pemetrexed 36Lomustine 36Ipilimumab 36Everolimus 35Magnetic Resonance Imaging 34Erlotinib Hydrochloride 34Drug Therapy 34Surveys and Questionnaires 33sargramostim 30

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

6 trials
RecentStart dateEnrollment
OTHER × neratinib × CNS × Clear all
NCT04374305 2026-05-06

INTUITT-NF2

Massachusetts General Hospital

Phase 2 Recruiting
109 enrolled
CNS

Ependymoma, Meningioma, Neuroma, Acoustic, Neurofibromatosis 2

NCT04965064 2025-12-15

Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling

University of Rochester

Phase 2 Recruiting
22 enrolled
BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT02932280 2025-12-05

Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment

Memorial Sloan Kettering Cancer Center

Phase 1/2 Active not recruiting
14 enrolled
CNSLymphoidOther hematologic neoplasm

Disease, Leukemia, Lymphoma, Recurrence, Central Nervous System Neoplasms

NCT02977780 2025-11-10

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

Dana-Farber Cancer Institute

Phase 2 Recruiting
460 enrolled
CNS

Glioblastoma

NCT04856475 2022-03-02

NeraBrain

Jules Bordet Institute

Phase 2 Withdrawn
BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT04760431 2021-06-02

TKIs vs. Pertuzumab in HER2+ Breast Cancer Patients With Active Brain Metastases (HER2BRAIN)

Second Affiliated Hospital, School of Medicine, Zhejiang University

Phase 2 Unknown
120 enrolled
CNS

Brain Neoplasms

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