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Phase

Phase 1 3Phase 1/2 1

Status

Terminated 4Completed 4Recruiting 2Withdrawn 1Unknown 1Active not recruiting 1

Sponsor Class

OTHER 2INDUSTRY 2

Study Type

Interventional 4

Sponsor

Cancer Type

Breast 8Gastrointestinal 4CNS 4Sarcoma 3Head & Neck 3Thoracic 2Gynecologic 2Dermatologic 2Tumor-Agnostic 1Lymphoid 1Genitourinary 1Endocrine 1

Conditions

Neuroblastoma 3Glioma 2Rhabdomyosarcoma 1Recurrence 1Neoplasms 1Medulloblastoma 1Diffuse Intrinsic Pontine Glioma 1

Interventions

Temozolomide 80Radiotherapy 41Bevacizumab 35Radiosurgery 23Magnetic Resonance Spectroscopy 20Cyclophosphamide 17Radiation 14Irinotecan 13Carboplatin 12Topotecan 11Nivolumab 11Lomustine 11Filgrastim 10Everolimus 10Etoposide 10Erlotinib Hydrochloride 10pembrolizumab 9Radiotherapy, Intensity-Modulated 9Ipilimumab 9Granulocyte Colony-Stimulating Factor 8Carmustine 8antineoplaston AS 2-1 7antineoplaston A10 7Surgical Procedures, Operative 7Mental Status and Dementia Tests 7Isotretinoin 7Granulocyte-Macrophage Colony-Stimulating Factor 7sargramostim 6Vincristine 6TPI-287 6

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Terminated × ribociclib × CNS × Clear all
NCT02780128 2026-03-10

NEPENTHE

Children's Hospital of Philadelphia

Phase 1 Terminated
66 enrolled
CNS

Neoplasms, Neuroblastoma

NCT05429502 2025-10-10

Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

Novartis

Phase 1 Terminated
12 enrolled
CNSSarcoma

Glioma, Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma

NCT02607124 2020-11-05

A Phase I/II Study of Ribociclib,a CDK4/6 Inhibitor, Following Radiation Therapy

Children's Hospital Medical Center, Cincinnati

Phase 1/2 Terminated
11 enrolled 10 charts
CNS

Diffuse Intrinsic Pontine Glioma, Glioma

NCT01747876 2019-11-22

Study of Safety and Efficacy in Patients With Malignant Rhabdoid Tumors (MRT) and Neuroblastoma

Novartis

Phase 1 Terminated
32 enrolled 14 charts
CNS

Neuroblastoma

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