Clinical Trials

57 enrolled

Glioblastoma, Gliosarcoma

NCT04901702 2026-04-13

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

CNSGastrointestinalGenitourinarySarcoma

90 enrolled

Neoplasms, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT05278208 2026-04-13

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

65 enrolled

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Central Nervous System Neoplasms

NCT06159166 2026-04-13

Mirda

24 enrolled

CNSDermatologic

NF1

NCT06465199 2026-04-13

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

289 enrolled

Phase 1/2 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Neuroblastoma, Sarcoma, Ewing, Osteosarcoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT07468136 2026-04-13

Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas

33 enrolled

CNSLymphoid

Astrocytoma, Glioblastoma, Glioma, Lymphoma, Follicular, Oligodendroglioma

NCT03277638 2026-04-09

Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM)

32 enrolled

Brain Neoplasms, Glioblastoma

NCT06541262 2026-04-09

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

104 enrolled

Liposarcoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT05987644 2026-04-08

DURABLE

56 enrolled

CNSThoracic

Brain Neoplasms, Lung Neoplasms

NCT03449238 2026-03-30

Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients

41 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT03596086 2026-03-30

HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM

62 enrolled

Astrocytoma, Glioblastoma

NCT03603405 2026-03-30

HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM

62 enrolled

Astrocytoma, Glioblastoma

NCT07501156 2026-03-30

H3K27M-specific Immune Effector Cells Targeting DMG/DIPG

30 enrolled

Diffuse Intrinsic Pontine Glioma

NCT03508752 2026-03-27

Neurocognitive Decline in Patients With Brain Metastases

80 enrolled

Brain Neoplasms

NCT04801147 2026-03-27

DENDR1

Phase 1/2 Completed

76 enrolled

Phase 1/2 Not yet recruiting

Glioblastoma

NCT07392957 2026-03-23

Safety and Efficacy of CTX-009 With or Without CTX-471 for Recurrent Glioblastoma

54 enrolled

Glioblastoma

NCT04085887 2026-03-20

Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures

12 enrolled

BreastCNSDermatologicOther hematologic neoplasmThoracic

Brain Neoplasms

NCT04789668 2026-03-18

Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases

Phase 1/2 Terminated

8 enrolled 13 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Hematologic Neoplasms, Triple Negative Breast Neoplasms

NCT06504381 2026-03-11

DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma

70 enrolled

Glioma

NCT06625190 2026-03-11

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

27 enrolled

Phase 1/2 Not yet recruiting

Chordoma, Myoepithelioma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Sarcoma, Clear Cell, Sarcoma, Alveolar Soft Part, Nerve Sheath Neoplasms, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT06639607 2026-03-10

PRiME II

68 enrolled

Diffuse Intrinsic Pontine Glioma, Ependymoma, Medulloblastoma, Recurrence

NCT05660408 2026-03-09

RNA PRIME

36 enrolled

Brain Neoplasms, Glioma

NCT05789589 2026-03-04

ADORATION

46 enrolled

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT06672575 2026-02-27

A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma

45 enrolled

Glioblastoma

NCT06622434 2026-02-20

NAVIG-1

35 enrolled

Glioblastoma

NCT07410494 2026-02-18

SELECT-CAR-NK

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicLymphoidOther hematologic neoplasmPlasma cellThoracic

85 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Carcinoma, Hepatocellular, Liver Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Melanoma, Multiple Myeloma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Leukemia, Myeloid, Acute

NCT07410676 2026-02-18

EBNK-ST-001