Clinical Trials Browser

NCT05630209 2026-04-17

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)

Phase 1/2 Active not recruiting

10 enrolled

CNS

Brain Neoplasms

NCT03157128 2026-04-16

LIBRETTO-001

Phase 1/2 Active not recruiting

857 enrolled 24 charts 6 FDA

BreastCNSEndocrineGastrointestinalHead & NeckThoracic

Thyroid Cancer, Papillary, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Site, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Central Nervous System Neoplasms, Carcinoma, Medullary

NCT01362803 2026-04-14

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

Phase 1/2 Active not recruiting

99 enrolled 4 FDA

CNS

Neurofibromatosis 1, Pain, Neurofibroma, Plexiform

NCT01089101 2026-04-13

Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma

Phase 1/2 Active not recruiting

217 enrolled

CNS

Astrocytoma, Neurofibromatosis 1

NCT03604978 2026-04-13

Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma

Phase 1/2 Active not recruiting

38 enrolled

CNS

Meningioma

NCT04528680 2026-04-13

SC9/ABX

Phase 1/2 Active not recruiting

57 enrolled

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT03277638 2026-04-09

Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM)

Phase 1/2 Active not recruiting

32 enrolled

CNS

Brain Neoplasms, Glioblastoma

NCT05094336 2026-03-31

MTAPESTRY 101

Phase 1/2 Active not recruiting

329 enrolled

CNSGastrointestinalHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Biliary Tract Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Glioma, Stomach Neoplasms

NCT03508752 2026-03-27

Neurocognitive Decline in Patients With Brain Metastases

Phase 1/2 Active not recruiting

80 enrolled

CNS

Brain Neoplasms

NCT02586857 2026-03-25

A Phase 1b/2, Multicenter, Open-label Study of ACP-196 in Subjects With Recurrent Glioblastoma Multiforme (GBM)

Phase 1/2 Active not recruiting

24 enrolled 10 charts

CNSLymphoidOther hematologic neoplasm

Glioblastoma, Leukemia, Lymphocytic, Chronic, B-Cell

NCT02650401 2026-03-25

STARTRK-NG

Phase 1/2 Active not recruiting

69 enrolled 2 FDA

CNSEndocrineGenitourinaryHead & NeckSarcoma

Thyroid Cancer, Papillary, Brain Neoplasms, Glioma, Medulloblastoma, Neoplasm Metastasis, Wilms Tumor, Neuroblastoma, Recurrence, Salivary Gland Neoplasms, Sarcoma, Sarcoma, Ewing, Central Nervous System Neoplasms, Nephroma, Mesoblastic

NCT03491683 2026-03-19

INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)

Phase 1/2 Active not recruiting

52 enrolled

CNS

Glioblastoma

NCT05660408 2026-03-09

RNA PRIME

Phase 1/2 Active not recruiting

36 enrolled

CNS

Brain Neoplasms, Glioma

NCT05593094 2026-02-25

A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors

Phase 1/2 Active not recruiting

210 enrolled

CNS

Brain Neoplasms

NCT03866109 2026-02-09

TEM-GBM

Phase 1/2 Active not recruiting

27 enrolled

CNS

Glioblastoma

NCT04478279 2026-02-09

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Phase 1/2 Active not recruiting

125 enrolled

BreastCNSDermatologicGenitourinary

Brain Neoplasms, Breast Neoplasms, Glioblastoma, Melanoma, Prostatic Neoplasms

NCT05635734 2026-02-05

Azeliragon and Chemoradiotherapy in Newly Diagnosed Glioblastoma

Phase 1/2 Active not recruiting

18 enrolled

CNS

Glioblastoma

NCT04201457 2026-02-03

A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

Phase 1/2 Active not recruiting

57 enrolled

CNS

Glioma

NCT01757626 2026-01-07

Combination Therapy of Antibody Hu3F8 With Granulocyte- Macrophage Colony Stimulating Factor (GM-CSF) in Patients With Relapsed/Refractory High-Risk Neuroblastoma

Phase 1/2 Active not recruiting

186 enrolled 3 FDA

CNS

Neuroblastoma

NCT03899792 2026-01-06

LIBRETTO-121

Phase 1/2 Active not recruiting

36 enrolled 13 charts 4 FDA

BreastCNSEndocrineGastrointestinalHead & NeckSarcomaThoracic

Thyroid Cancer, Papillary, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Site, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Central Nervous System Neoplasms, Myofibromatosis, Carcinoma, Medullary

NCT05309668 2025-12-18

SPRINKLE

Phase 1/2 Active not recruiting

36 enrolled 37 charts

CNS

Neurofibromatosis 1

NCT05256290 2025-12-09

Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations

Phase 1/2 Active not recruiting

200 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04538742 2025-12-08

DB-07

Phase 1/2 Active not recruiting

245 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT05521048 2025-12-08

Doxycycline in Cutaneous Schwannoma (NF2)

Phase 1/2 Active not recruiting

19 enrolled

CNS

Neurofibromatosis 2

NCT02932280 2025-12-05

Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment

Phase 1/2 Active not recruiting

14 enrolled

CNSLymphoidOther hematologic neoplasm

Disease, Leukemia, Lymphoma, Recurrence, Central Nervous System Neoplasms

NCT03212742 2025-12-04

OLA-TMZ-RTE-01

Phase 1/2 Active not recruiting

91 enrolled

CNS

Glioma

NCT03687957 2025-11-25

rhIL-7-hyFc on Increasing Lymphocyte Counts in Patients With Newly Diagnosed Non-severe Lymphopenic Gliomas Following Radiation and Temozolomide

Phase 1/2 Active not recruiting

42 enrolled 19 charts

CNS

Glioma

NCT03233152 2025-11-21

GlitIpNi

Phase 1/2 Active not recruiting

110 enrolled

CNS

Glioblastoma, Recurrence

NCT06521567 2025-11-12

A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

Phase 1/2 Active not recruiting

83 enrolled

CNSDermatologicGastrointestinalLymphoidSarcoma

Fibrolamellar hepatocellular carcinoma, Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioblastoma, Carcinoma, Hepatocellular, Hodgkin Disease, Melanoma, Rhabdomyosarcoma, Osteosarcoma, Hepatoblastoma

NCT02696993 2025-11-10

Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer

Phase 1/2 Active not recruiting

80 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT06462222 2025-09-29

Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors

Phase 1/2 Active not recruiting

45 enrolled

CNS

Meningeal Carcinomatosis

NCT04446962 2025-09-25

LOC-R01

Phase 1/2 Active not recruiting

118 enrolled

CNSLymphoid

Lymphoma, Neurologic Manifestations, Lymphoma, Large B-Cell, Diffuse, Central Nervous System Neoplasms

NCT04910022 2025-08-19

Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma

Phase 1/2 Active not recruiting

150 enrolled

CNS

Glioblastoma

NCT01192555 2025-08-01

ATOMIC

Phase 1/2 Active not recruiting

11 enrolled

CNS

Neuroblastoma

NCT04121455 2025-06-25

GLORIA

Phase 1/2 Active not recruiting

117 enrolled

CNS

Brain Neoplasms, Glioblastoma

NCT04019262 2025-06-18

Short Course Chemo-Radiation Therapy for Patients With Newly Diagnosed Glioblastoma

Phase 1/2 Active not recruiting

2 enrolled

CNS

Glioblastoma, Lymphopenia

NCT06668987 2025-06-12

A Study of the Boron Neutron Capture Therapy (BNCT) Using B10 L-BPA in Recurrent Meningioma

Phase 1/2 Active not recruiting

10 enrolled

CNS

Meningioma

NCT00911560 2025-06-05

Bivalent Vaccine With Escalating Doses of the Immunological Adjuvant OPT-821, in Combination With Oral β-glucan for High-Risk Neuroblastoma

Phase 1/2 Active not recruiting

374 enrolled

CNS

Neuroblastoma

NCT03673787 2025-05-14

IceCAP

Phase 1/2 Active not recruiting

87 enrolled

CNS

Glioblastoma

NCT05664243 2025-05-01

A Phase 1b / 2 Drug Resistant Immunotherapy With Activated, Gene Modified Allogeneic or Autologous γδ T Cells (DeltEx) in Combination With Maintenance Temozolomide in Subjects With Recurrent or Newly Diagnosed Glioblastoma

Phase 1/2 Active not recruiting

4 enrolled

CNS

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms by Site, Central Nervous System Neoplasms

NCT04922723 2025-04-18

PRIDE

Phase 1/2 Active not recruiting

16 enrolled

CNS

Glioblastoma

NCT04881032 2025-02-13

NANO-GBM

Phase 1/2 Active not recruiting

66 enrolled

CNS

Glioblastoma

NCT03373097 2025-02-05

Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk and/or Relapsed/Refractory Neuroblastoma or Other GD2-positive Solid Tumors

Phase 1/2 Active not recruiting

42 enrolled

CNSSarcoma

Neuroblastoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma

NCT04758533 2024-12-27

AloCELYVIR

Phase 1/2 Active not recruiting

13 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Medulloblastoma, Recurrence

NCT04954001 2024-11-12

Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1

Phase 1/2 Active not recruiting

160 enrolled

CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT01985087 2024-10-31

A Study Using Radiation Therapy and Temozolomide to Treat Glioblastoma in Patients Over 70

Phase 1/2 Active not recruiting

18 enrolled

CNS

Glioblastoma

NCT04913337 2024-10-02

Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

Phase 1/2 Active not recruiting

179 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Melanoma, Mesothelioma, Ovarian Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT04911621 2024-05-08

ADDICT-pedGLIO

Phase 1/2 Active not recruiting

10 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Glioma