Clinical Trials
54 trialsNCT06466798 2026-01-08
Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies
The University of Texas Health Science Center, Houston
Phase 1 Withdrawn
NCT05341947 2025-10-22
Activated Autologous T Cells Against Glioma Cancer Stem Cell Antigens for Patients With Recurrent Glioblastoma
Cedars-Sinai Medical Center
Phase 1 Withdrawn
NCT05720624 2025-10-22
Pharmacodynamic Analyses of Metabolic Agents Following Brain Radiation
Mayo Clinic
Phase 1 Withdrawn
NCT04500548 2025-09-10
Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study
National Cancer Institute (NCI)
Phase 1 Withdrawn
NCT06501911 2025-07-22
A Study of Bicalutamide With Brain Re-irradiation to Treat Recurrent/Progressive High Grade Glioma
University of Nebraska
Phase 1 Withdrawn
NCT02145910 2025-05-02
Vemurafenib Combined With Whole Brain Radiation Therapy or Radiosurgery in Patients With BRAF Mutation-Positive Melanoma and Brain Metastases
Thomas Jefferson University
Phase 1 Withdrawn
NCT06463184 2024-12-04
Study to Assess Xevinapant in Preoperative Subjects With Recurrent High-Grade Glioma (rHGG)
H. Lee Moffitt Cancer Center and Research Institute
Phase 1 Withdrawn
NCT04521946 2024-10-26
Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer
M.D. Anderson Cancer Center
Phase 1 Withdrawn
NCT03990597 2024-10-09
StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord
M.D. Anderson Cancer Center
Phase 1 Withdrawn
NCT05773664 2024-09-19
Dexamethasone and Azeliragon for Management of Post-Resection Cerebral Edema in Patients with Glioblastoma
City of Hope Medical Center
Phase 1 Withdrawn
NCT05082493 2024-06-06
A Multicenter, Study of the Safety and Pharmacokinetics of Intravenously Infused Berubicin in Pediatric Patients With Progressive, Refractory, or Recurrent High Grade Gliomas
WPD Pharmaceuticals Sp. z o.o.
Phase 1 Withdrawn
NCT05120960 2024-04-17
A Phase 1a/1b Study to Determine the Recommended Phase 2 Dose, of Tepotinib in Participants With MET Alterations and Brain Tumors
M.D. Anderson Cancer Center
Phase 1 Withdrawn
NCT05304663 2024-04-08
GLIOASTRA
Philogen S.p.A.
Phase 1 Withdrawn
NCT06137651 2024-04-01
Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis
Northwestern University
Phase 1 Withdrawn
NCT05952687 2024-03-27
Trial of Idasanutlin and Selinexor Therapy for Children With Progressive/Relapsed AT/RT or Extra-CNS Malignant Rhabdoid Tumors
St. Jude Children's Research Hospital
Phase 1 Withdrawn
NCT05666349 2024-03-26
RiNG
University College, London
Phase 1 Withdrawn
NCT04741984 2023-05-15
DEMAND
Duke University
Phase 1 Withdrawn
NCT03209869 2022-09-13
Treatment of Relapsed or Refractory Neuroblastoma and Osteosarcoma With Expanded Haploidentical NK Cells and Hu14.18-IL2
University of Wisconsin, Madison
Phase 1 Withdrawn
NCT04200066 2022-08-22
A Study of Maprotiline in Combination With Tamoxifen and Temozolomide for Recurrent Glioblastoma
University of Rochester
Phase 1 Withdrawn
NCT04585724 2021-10-18
Stereotactic Radiosurgery With Abemaciclib, Ribociclib, or Palbociclib in Treating Patients With Hormone Receptor Positive Breast Cancer With Brain Metastases
Emory University
Phase 1 Withdrawn
NCT04854044 2021-05-12
ONC201 and Radiation Therapy Before Surgery for the Treatment of Recurrent Glioblastoma
Jonsson Comprehensive Cancer Center
Phase 1 Withdrawn
NCT03177252 2020-10-22
Scalp block
Washington University School of Medicine
Phase 1 Withdrawn
NCT04270461 2020-10-22
NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors
Jiujiang University Affiliated Hospital
Phase 1 Withdrawn
NCT01916187 2020-09-21
Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma
Canadian Cancer Trials Group
Phase 1 Withdrawn
NCT00836628 2020-08-05
Study of Busulfan for Refractory Central Nervous System (CNS) Tumors
Ann & Robert H Lurie Children's Hospital of Chicago
Phase 1 Withdrawn
NCT03480867 2019-08-14
PARADIGMA
McGill University Health Centre/Research Institute of the McGill University Health Centre
Phase 1 Withdrawn
NCT02557854 2019-03-19
HIFU Hyperthermia With Liposomal Doxorubicin (DOXIL) for Relapsed or Refractory Pediatric and Young Adult Solid Tumors
University of Texas Southwestern Medical Center
Phase 1 Withdrawn
NCT03275558 2018-07-19
Clinical Trial of the Use of the Nasal Spray of Patients With Recurrence of Glioblastoma
Center Trials & Treatment
Phase 1 Withdrawn
NCT00944580 2017-11-24
A Vaccine Study for High Risk Cancers
Penn State University
Phase 1 Withdrawn
NCT02745756 2017-08-30
A Combined Cell Therapy Approach to the Treatment of Neuroblastoma
H. Lee Moffitt Cancer Center and Research Institute
Phase 1 Withdrawn
NCT01130623 2017-07-02
A Phase I Study of Pazopanib as a Single Agent for Children With Refractory Solid Tumors
National Institutes of Health Clinical Center (CC)
Phase 1 Withdrawn
NCT01182883 2017-07-02
A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors
National Institutes of Health Clinical Center (CC)
Phase 1 Withdrawn
NCT01236586 2017-07-02
RO4929097 in Children With Relapsed/Refractory Solid or CNS Tumors, Lymphoma, or T-Cell Leukemia
National Institutes of Health Clinical Center (CC)
Phase 1 Withdrawn
NCT02439788 2017-06-14
GINAKIT
Baylor College of Medicine
Phase 1 Withdrawn
NCT00937417 2017-04-24
S0716 Vandetanib and Docetaxel in Treating Patients With Advanced Solid Tumors
SWOG Cancer Research Network
Phase 1 Withdrawn
NCT01052363 2017-02-09
OXC401-PO1s/WVU 1309 - A Pilot Study of Fosbretabulin With Bevacizumab in Recurrent High-Grade Gliomas
West Virginia University
Phase 1 Withdrawn
NCT00703859 2016-02-22
Combining Radiotherapy and Temozolomide With Dichloroacetate in Patients With Newly Diagnosed Glioblastoma
AHS Cancer Control Alberta
Phase 1 Withdrawn
NCT01941849 2015-12-21
VIBRaNT
University College, London
Phase 1 Withdrawn
NCT01861990 2015-05-22
Valproic Acid in Childhood Progressive Brain Tumors
Medical University of South Carolina
Phase 1 Withdrawn
NCT01317212 2015-04-17
Dose-Escalation Study of Carboplatin Administration Into the Brain for Glioblastoma Multiforme
North Bristol NHS Trust
Phase 1 Withdrawn
NCT00247403 2015-04-10
Safety Study of 2DG With Stereotactic Radiosurgery
University of Iowa
Phase 1 Withdrawn
NCT01320787 2014-10-23
18-F-Fluoroacetate as PET Imaging Agent
M.D. Anderson Cancer Center
Phase 1 Withdrawn
NCT00458744 2014-08-08
Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment
Children's Oncology Group
Phase 1 Withdrawn
NCT02055196 2014-06-02
Genetically Modified Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas
City of Hope Medical Center
Phase 1 Withdrawn
NCT02080949 2014-03-07
Phase I Dose Escalation in Patients With 1-3 Unresectable Brain Metastases
Barretos Cancer Hospital
Phase 1 Withdrawn
NCT01854099 2014-01-14
PERFORMANCE
University of Florida
Phase 1 Withdrawn
NCT01319838 2013-12-10
Aflac ST1001
Emory University
Phase 1 Withdrawn
NCT00949026 2013-11-21
Assessment of Systemically Administered Torisel Delivery to Brain Tumors by Intratumoral Microdialysis
Emory University
Phase 1 Withdrawn
NCT01697514 2013-08-27
A Study of LY2940680 in Pediatric Medulloblastoma or Rhabdomyosarcoma
Eli Lilly and Company
Phase 1 Withdrawn
NCT00734864 2012-11-21
Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma
Duke University
Phase 1 Withdrawn