Clinical Trials

Glioma

NCT04614909 2026-05-14

Study of Pamiparib in Newly Diagnosed and rGBM

50 enrolled

Glioblastoma

NCT04895592 2026-05-14

Radiosurgery Before Surgery for the Treatment of Brain Metastases

26 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT05773326 2026-05-14

Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG

5 enrolled

Glioblastoma, Glioma

NCT07485049 2026-05-14

BGB-58067 in Newly Diagnosed Glioblastoma Patients With MTAP-Deleted Tumors

78 enrolled

Glioblastoma

NCT07585851 2026-05-14

Administration of Repurposed Ketoconazole in Glioma Patients

80 enrolled

CNSLymphoid

Glioblastoma, Lymphoma, Follicular

NCT07210632 2026-05-11

Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)

38 enrolled

Phase EARLY_PHASE1 Withdrawn

Brain Neoplasms, Glioma

NCT03554707 2026-05-08

SGT-53 in Children With Recurrent or Progressive CNS Malignancies

Central Nervous System Neoplasms

NCT07284069 2026-05-07

SENIPERA

36 enrolled

Glioblastoma

NCT06636162 2026-05-06

Window of Opportunity Study of DSP-0390 in Gliomas

20 enrolled

Brain Neoplasms, Glioma

NCT05091866 2026-05-05

Natural Progesterone for the Treatment of Recurrent Glioblastoma

4 enrolled

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT06810336 2026-05-04

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery

40 enrolled

Brain Injuries, Brain Neoplasms, Pain

NCT03541720 2026-04-29

18F-Fluorodopamine PET Studies of Neuroblastoma and Pheochromocytoma

13 enrolled

CNSEndocrine

Neuroblastoma, Pheochromocytoma

NCT05555550 2026-04-29

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

30 enrolled

Glioma

NCT07017816 2026-04-29

JACOB

18 enrolled

Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms

NCT05676489 2026-04-27

MeFAMP for Imaging System A Amino Acid Transport in Primary and Metastatic Brain Tumors

28 enrolled

Glioma

NCT07538128 2026-04-20

Evaluating Safety, Tolerability, and Preliminary Efficacy of YSCH-01 Monotherapy and in Combination With Atezolizumab for Recurrent Glioblastoma

Adenoviridae Infections, Glioblastoma

NCT03163368 2026-04-17

Dose Escalation Trial of Neoadjuvant Radiosurgery for the Treatment of Metastatic Brain Tumors

25 enrolled

Brain Neoplasms, Neoplasm Metastasis

NCT04656535 2026-04-17

AB154 Combined With AB122 for Recurrent Glioblastoma

46 enrolled

Glioblastoma, Recurrence

NCT03122197 2026-04-16

Study of Letrozole in Recurrent Gliomas

39 enrolled

Brain Neoplasms

NCT05047913 2026-04-15

Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR

Phase EARLY_PHASE1 Enrolling by invitation

20 enrolled

CNSGynecologic

Brain Neoplasms, Uterine Cervical Neoplasms

NCT07520214 2026-04-09

Clinical Study on the Safety and Immunogenicity of Specific Cancer Vaccines in Preventing Recurrence of Glioblastoma

9 enrolled

Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype

NCT07515924 2026-04-07

Oral Gallium Maltolate for Recurrent Glioblastoma

8 enrolled

Glioblastoma

NCT05704933 2026-04-06

Pilot Study of Nivolumab w/Ipilimumab or Relatlimab in Surgically Resectable Melanoma Brain Metastases

1 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT04040088 2026-03-31

An Investigational Scan (68Ga-DOTATATE PET/CT) in Diagnosing Pediatric Metastatic Neuroendocrine Tumors

20 enrolled

Ganglioneuroma, Neuroblastoma, Ganglioneuroblastoma

NCT07493447 2026-03-25

Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures

30 enrolled

CNSEndocrine

Brain Neoplasms, Glioblastoma, Meningioma, Neoplasms, Neuroma, Acoustic, Pituitary Neoplasms

NCT03796273 2026-03-20

Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases

Astrocytoma, Glioma, Oligodendroglioma

NCT04655404 2026-03-18

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

Diffuse Intrinsic Pontine Glioma, Glioma

NCT05577416 2026-03-18

AB-218-IIT-201

14 enrolled

Astrocytoma, Glioma, Oligodendroglioma

NCT06333899 2026-03-12

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma

NCT07039760 2026-03-11

Asciminib With or Without Sildenafil for Brain Tumors

12 enrolled

Brain Neoplasms

NCT05076513 2026-03-09

Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma

42 enrolled

Glioblastoma, Glioma

NCT05182905 2026-03-09

AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients

97 enrolled

Glioblastoma, Glioma

NCT02933736 2026-03-06

Ribociclib (LEE011) in Preoperative Glioma and Meningioma Patients

48 enrolled

Glioblastoma, Meningioma

NCT04391595 2026-03-06

LY3214996 Plus Abemaciclib in Recurrent Glioblastoma Patients

42 enrolled

Glioblastoma, Glioma

NCT07268053 2026-03-06

A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (ADC), in Patients With Recurrent Grade 4 Glioma and Patients With Brain Metastases

Glioblastoma

NCT05636540 2026-02-27

In Vivo PARP-1 Expression With 18F-FluorThanatrace PET/CT in Patients With Pheochromocytoma and Paraganglioma

30 enrolled

CNSEndocrine

Paraganglioma, Pheochromocytoma

NCT05804227 2026-02-27

Window-of-Opportunity Trial of Ulixertinib for MAPK-Activated Gliomas

40 enrolled

Glioma

NCT06942039 2026-02-27

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

Medulloblastoma, Neuroblastoma, Pinealoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

NCT07076472 2026-02-23

Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma

8 enrolled

Glioblastoma

NCT03970226 2026-02-17

Tocilizumab in Children With ACP

9 enrolled

Craniopharyngioma

NCT04173104 2026-02-09

PET and MRI Imaging of Brain Tumors Using [18F]PARPi

5 enrolled

Brain Neoplasms

NCT05406700 2026-02-09

Niraparib In Recurrent IDH 1/2 Gliomas

16 enrolled

Glioma

NCT07387666 2026-02-06

Imaging Acetadote Metabolism in Glioblastoma

Glioblastoma

NCT07050836 2026-02-04

Contrast Enhanced Ultrasound in Neurosurgery to Improve Glioma Visualization and Border Demarcation

100 enrolled

Brain Neoplasms, Glioma

NCT07384390 2026-02-04

TH-CAR-027 for Grade 4 Gliomas

21 enrolled

R/R Grade 4 Glioma

NCT07025226 2026-01-26

Senolytics

Glioma

NCT04825275 2026-01-23

Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial

7 enrolled 12 charts

Brain Neoplasms, Glioblastoma

NCT04869449 2026-01-07

Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas

1 enrolled