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NCT06809322 2026-05-22

VIGOR

Phase 3 Recruiting

Astrocytoma

NCT02724579 2026-05-20

Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

Phase 2 Active not recruiting

Medulloblastoma

NCT06319027 2026-05-15

GABLE

Phase 2 Recruiting

Glioblastoma

NCT06894979 2026-05-15

Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma

Phase 1 Recruiting

Astrocytoma

NCT03550391 2026-05-12

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Phase 3 Recruiting

Brain Neoplasms

NCT05108298 2026-05-07

Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

Phase NA Recruiting

BreastCNSDermatologicGastrointestinalGynecologicHead & NeckLymphoidOther hematologic neoplasmSarcoma

Bone Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Leukemia, Lymphoma, Melanoma, Sarcoma, Thyroid Neoplasms, Central Nervous System Neoplasms, Pyloric Stenosis, Hypertrophic

NCT03115333 2026-05-06

DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma

Phase NA Active not recruiting

Glioblastoma, Gliosarcoma

NCT04647916 2026-05-06

Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases

Phase 2 Active not recruiting

Brain Neoplasms

NCT02176967 2026-05-05

Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma

Phase 3 Active not recruiting

Neuroblastoma, Ganglioneuroblastoma

NCT02402244 2026-05-05

Project: Every Child for Younger Patients With Cancer

75,000 enrolled

CNSDermatologicEndocrineLymphoidMyeloidNETSarcoma

Carcinoma in Situ, Ganglioneuroma, Lymphoproliferative Disorders, Melanoma, Myeloproliferative Disorders, Neoplasms, Pheochromocytoma, Central Nervous System Neoplasms, Nephroma, Mesoblastic, Desmoid Tumors, Neuroendocrine Tumors

NCT04851119 2026-05-05

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Phase 1/2 Recruiting

CNSDermatologicGastrointestinalGenitourinaryGynecologicLymphoidSarcoma

Carcinoma, Hepatocellular, Lymphoma, Non-Hodgkin, Melanoma, Wilms Tumor, Neuroblastoma, Ovarian Neoplasms, Sarcoma, Ewing, Osteosarcoma, Colorectal Neoplasms, Endometrial Neoplasms, Hepatoblastoma, Desmoid Tumors

NCT04870944 2026-05-05

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

Phase 1/2 Recruiting

Diffuse Intrinsic Pontine Glioma, Lymphoma

NCT05382338 2026-05-05

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Phase 3 Recruiting

Medulloblastoma

NCT01503086 2026-04-23

Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy

Phase NA Completed

45 enrolled 10 charts

Brain Neoplasms

NCT05934630 2026-04-23

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

Choroid Plexus Carcinoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Rhabdoid Tumor

NCT03033992 2026-04-06

Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG

Phase NA Active not recruiting

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioma

NCT04978727 2026-04-06

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Phase 1 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Ependymoma, Glioblastoma, Medulloblastoma, Oligodendroglioma

NCT06858501 2026-03-19

Comparing 123I-MIBG and 18F-MFBG Imaging in Patients With Newly Diagnosed, High Risk Neuroblastoma

Phase 2 Not yet recruiting

Ganglioneuroblastoma

NCT03126916 2026-02-27

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Phase 3 Recruiting

Neuroblastoma, Ganglioneuroblastoma

NCT03389802 2026-02-20

Phase I Study of APX005M in Pediatric Central Nervous System Tumors

Phase 1 Active not recruiting

32 enrolled 16 charts

Ependymoma, Glioblastoma, Medulloblastoma

NCT03794349 2026-02-18

Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma

Phase 2 Active not recruiting

94 enrolled 14 charts

Neuroblastoma

NCT05904119 2026-02-17

LEGATO

Phase 3 Recruiting

Glioblastoma

NCT04482933 2026-02-10

HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma

Phase 2 Withdrawn

Brain Neoplasms, Glioblastoma, Glioma, Herpes Simplex, Neoplasms, Virus Diseases

NCT04743661 2026-02-05

131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma

Phase 2 Active not recruiting

Ependymoma, Medulloblastoma

NCT04201457 2026-02-03

A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

Phase 1/2 Active not recruiting

Glioma

NCT00336024 2026-01-23

Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma

Phase 3 Completed

91 enrolled 24 charts

Medulloblastoma

NCT01175356 2026-01-23

Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin

Phase 1 Completed

99 enrolled 11 charts

Neuroblastoma, Ganglioneuroblastoma

NCT03057626 2026-01-09

Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma

Active not recruiting

Neuroblastoma

NCT04113408 2026-01-06

MENTHE

Meningioma

NCT04113395 2026-01-05

CAMOMILLE

Meningioma

NCT04295759 2026-01-05

INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

Phase 1 Completed

13 enrolled 15 charts

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Pyloric Stenosis, Hypertrophic

NCT05049148 2026-01-05

Platon

Phase NA Recruiting

Brain Neoplasms, Glioma, Inflammation

NCT04939597 2025-12-22

A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for a Brain Tumor

Phase 3 Active not recruiting

Central Nervous System Carcinoma

NCT05259605 2025-12-17

Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification

Ependymoma, Glioma, Hemangiopericytoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Choroid Plexus Neoplasms, Hemangioblastoma

NCT06054295 2025-12-16

Somatic Mosaicism in Twins Discordant for Childhood Cancer

Central Nervous System Neoplasms

NCT03834961 2025-12-02

Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia

Phase 2 Active not recruiting

33 enrolled 18 charts

Central Nervous System Neoplasms

NCT03224104 2025-11-26

STEAM

Phase 1 Completed

71 enrolled 18 charts

Astrocytoma, Glioblastoma

NCT01117168 2025-11-24

Enrollment on the Childhood Cancer Research Network (CCRN) of the Children's Oncology Group

Active not recruiting

57,816 enrolled

CNSOther hematologic neoplasmSarcoma

Brain Neoplasms, Leukemia, Neoplasms, Sarcoma

NCT01602666 2025-11-20

Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors

Phase 2 Completed

262 enrolled 17 charts

Central Nervous System Nongerminomatous Germ Cell Tumor

NCT00904241 2025-11-13

Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma

Active not recruiting

10,000 enrolled

Neuroblastoma, Ganglioneuroblastoma

NCT03904862 2025-10-30

Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

Phase 1/2 Terminated

Microphthalmia, Isolated, with Coloboma 5, Medulloblastoma

NCT04385277 2025-10-27

Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)

Phase 2 Active not recruiting

41 enrolled 13 charts

Neuroblastoma, Ganglioneuroblastoma

NCT04402073 2025-10-23

PersoMed-I

Phase 2 Terminated

Medulloblastoma

NCT03418961 2025-10-08

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

Phase 3 Recruiting

Brain Neoplasms, Breast Neoplasms, Cardiotoxicity

NCT06326190 2025-09-16

LUMEN-1

Phase 2 Recruiting

Meningioma

NCT04511013 2025-09-11

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

Phase 2 Recruiting

CNSDermatologic

Brain Neoplasms, Melanoma

NCT00978458 2025-09-08

Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma

Phase 3 Active not recruiting

Astrocytoma, Brain Neoplasms, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Neurotoxicity Syndromes

NCT06390579 2025-09-08

BRAIN

Brain Neoplasms, Optic Atrophy, Optic Nerve Diseases, Optic Neuritis, Papilledema, Optic Neuropathy, Ischemic

NCT02234050 2025-07-10

Trabectedin for Recurrent Grade II/III Meningioma

Phase 2 Completed

90 enrolled 18 charts

Recurrent High Grade Meningioma

NCT03345095 2025-07-01

MIRAGE

Phase 3 Completed

749 enrolled 15 charts

Glioblastoma