Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma
Phase 2 Completed
47 enrolled
Study of Disease Severity in Adults With Neurofibromatosis Type 1 (NF1)
Completed
313 enrolled
Natural History and Biology of Skin Neurofibromas in Neurofibromatosis Type 1
Completed
17 enrolled
Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors
Completed
76 enrolled
NK White Blood Cells and Interleukin in Children and Young Adults With Advanced Solid Tumors
Phase 1 Completed
16 enrolled
Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)
Phase 2 Completed
20 enrolled 12 charts
Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors
Phase 2 Completed
36 enrolled
Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases
Phase 2 Completed
344 enrolled 11 charts
Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1
Phase 1 Completed
10 enrolled
Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)
Phase 2 Completed
23 enrolled 11 charts
Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)
Phase 2 Completed
18 enrolled 12 charts
Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases
Completed
35 enrolled
Natural History of and Specimen Banking for People With Tumors of the Central Nervous System
Completed
1,214 enrolled
Rare CNS Tumors Outcomes &Risk
Completed
326 enrolled
Immersive Virtual Reality (VR) at the Time of Clinical Evaluation to Improve Psychological Distress and Anxiety in Primary Brain Tumor (PBT) Patients
Phase 2 Completed
61 enrolled 20 charts
Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma
Phase 3 Completed
1,449 enrolled 17 charts
Testing the Combination of Two Immunotherapy Drugs (Magrolimab and Dinutuximab) in Patients With Relapsed or Refractory Neuroblastoma or Relapsed Osteosarcoma
Phase 1 Completed
12 enrolled 12 charts
Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
Phase 1 Completed
17 enrolled
Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread
Phase 1 Completed
3 enrolled 12 charts
Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab
Phase 2 Completed
35 enrolled 13 charts
Phase 2 Study of Bintrafusp Alfa in Recurrent/Metastatic Olfactory Neuroblastoma (BARON).
Phase 2 Completed
11 enrolled 14 charts
Carboplatin and Bevacizumab for Recurrent Ependymoma
Phase 2 Completed
35 enrolled 17 charts
Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers
Phase 2 Completed
133 enrolled
Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver Dysfunction
Phase 1 Completed
37 enrolled
Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)
Phase 2 Completed
21 enrolled 11 charts
Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)
Phase 2 Completed
4 enrolled 12 charts
Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma
Phase 1 Completed
74 enrolled
Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma
Phase 2 Completed
75 enrolled 17 charts
Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)
Phase 2 Completed
6 enrolled 12 charts
Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma
Phase 1 Completed
29 enrolled
Incidence of Malignant Peripheral Nerve Sheath Tumor (MPNST) Development in Participants With Neurofibromatosis Type 1 (NF1) Receiving and Not Receiving Medical Therapies Directed at Plexiform Neurofibromas (PN)
Completed
296 enrolled
Analysis of Data Collected From Individuals Administered Neurobehavioral Assessments
Completed
598 enrolled
Relationship Stressors in Parents of Children With Cancer or Neurofibromatosis Type 1 (NF1)
Completed
262 enrolled
Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade
Phase 1 Completed
21 enrolled 9 charts
Validating Pain Scales in Children and Young Adults
Completed
252 enrolled
Medication Adherence in Children, Adolescents and Adults With Neurofibromatosis Type 1(NF1) on Clinical Treatment Trials
Phase NA Completed
12 enrolled 18 charts
A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors
Phase 1 Completed
15 enrolled
Systematically Assessing Changes in Plexiform Neurofibroma Related Disfigurement From Photographs of Subjects With Neurofibromatosis Type 1 on a Phase 2 Clinical Trial
Completed
52 enrolled
Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors
Phase 1 Completed
Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma
Phase 2/3 Completed
101 enrolled 15 charts
Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas
Phase 1 Completed
46 enrolled 20 charts
Cabozantinib S-Malate in Treating Younger Patients With Recurrent or Refractory Solid Tumors
Phase 1 Completed
41 enrolled 20 charts
Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma
Phase 2 Completed
11 enrolled 11 charts
Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma
Phase 2 Completed
7 enrolled 20 charts
Stereotactic Radiosurgery in Treating Patients With Brain Tumors
Phase 1 Completed
Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer
Phase 2 Completed
143 enrolled 24 charts
Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas
Phase 1/2 Completed
140 enrolled 23 charts
Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors
Phase 1 Completed
21 enrolled 15 charts
Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors
Phase 1/2 Completed
76 enrolled 25 charts
Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers
Phase NA Completed
10 enrolled 16 charts