Clinical Trials

Phase EARLY_PHASE1 Recruiting

Brain Neoplasms

NCT03122197 2026-04-16

Study of Letrozole in Recurrent Gliomas

39 enrolled

Phase 1/2 Active not recruiting

Brain Neoplasms

NCT03157128 2026-04-16

LIBRETTO-001

857 enrolled 24 charts 6 FDA

BreastCNSEndocrineGastrointestinalHead & NeckThoracic

Thyroid Cancer, Papillary, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Site, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Central Nervous System Neoplasms, Carcinoma, Medullary

NCT03922555 2026-04-16

ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas

18 enrolled

Central Nervous System Neoplasms

NCT05013892 2026-04-16

NTS-WBRT in Brain Metastases

41 enrolled

Brain Neoplasms

NCT05064280 2026-04-16

Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases

104 enrolled

Brain Neoplasms, Neoplasms

NCT05317858 2026-04-16

LIMITLESS

Phase 3 Recruiting

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT05580562 2026-04-16

ACTION

Phase 3 Recruiting

510 enrolled

Glioma

NCT05588141 2026-04-16

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

Phase 1/2 Recruiting

96 enrolled

Brain Neoplasms, Glioma, Neoplasms, Recurrence

NCT06955169 2026-04-16

MOMENTUM-1

153 enrolled

Meningioma

NCT07042620 2026-04-16

A Study to Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery

15 enrolled

Glioblastoma, Glioma

NCT07100730 2026-04-16

IPAX BrIGHT

Phase 3 Recruiting

50 enrolled

Phase 1/2 Not yet recruiting

Brain Neoplasms, Glioblastoma, Neoplasm Recurrence, Local, Neoplasms, Central Nervous System Neoplasms

NCT07416188 2026-04-16

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

40 enrolled

Phase 2 Not yet recruiting

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Nerve Tissue, Recurrence, Central Nervous System Neoplasms

NCT07533942 2026-04-16

A Study of JZP3507 (ONC206) in Recurrent Grade 2 or 3 Meningioma

Meningioma

NCT00814021 2026-04-15

Sunitinib in Treating Patients With Kidney Cancer That Has Spread to the Brain

Phase 2 Completed

Phase NA Active not recruiting

CNSGenitourinary

Brain Neoplasms, Carcinoma, Renal Cell, Kidney Neoplasms, Neoplasm Metastasis

NCT02481349 2026-04-15

Couples-Based Yoga Program in Improving Quality of Life in Patients With High-Grade Glioma Undergoing Radiation Therapy and Their Partners

216 enrolled

Phase NA Active not recruiting

Glioma

NCT02693990 2026-04-15

A Trial of Increased Dose Intensity Modulated Proton Therapy (IMPT) for High-Grade Meningiomas

Phase 2 Active not recruiting

Brain Neoplasms, Meningioma

NCT03175432 2026-04-15

Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases

29 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT03286335 2026-04-15

Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

100 enrolled

Brain Neoplasms

NCT03451799 2026-04-15

Ketogenic Diet in Combination With Standard-of-care Radiation and Temozolomide for Patients With Glioblastoma

Glioblastoma

NCT04308330 2026-04-15

NYMC195

CNSGastrointestinalGenitourinarySarcoma

Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Hepatoblastoma

NCT04659811 2026-04-15

Stereotactic Radiosurgery and Immunotherapy (Pembrolizumab) for the Treatment of Recurrent Meningioma

Phase 2 Active not recruiting

35 enrolled

Phase 2 Active not recruiting

Meningioma

NCT04762069 2026-04-15

A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme

252 enrolled

Brain Neoplasms, Glioblastoma

NCT04897321 2026-04-15

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

CNSDermatologicGastrointestinalGenitourinarySarcoma

48 enrolled

Adrenal Cortex Neoplasms, Carcinoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT05047913 2026-04-15

Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR

Phase EARLY_PHASE1 Active not recruiting

20 enrolled

CNSGynecologic

Brain Neoplasms, Uterine Cervical Neoplasms

NCT05057702 2026-04-15

PNOC027

74 enrolled

CNSGastrointestinalOther solid neoplasmSarcomaThoracic

Ependymoma, Medulloblastoma

NCT05275478 2026-04-15

Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors

Phase 1/2 Terminated

110 enrolled

Glioblastoma, Mesothelioma, Sarcoma, Cholangiocarcinoma, Neurofibrosarcoma

NCT05849662 2026-04-15

A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia

Phase 1/2 Recruiting

58 enrolled

CNSOther hematologic neoplasm

Neurofibromatosis 1, Leukemia, Myelomonocytic, Juvenile

NCT06015295 2026-04-15

A Pilot Study to Assess the Clinical Utility of 18F-Fluciclovine (Axumin) PET-CT for Detecting True-versus Pseudo-Progression of Brain Metastases on Immunotherapy

20 enrolled

Brain Neoplasms

NCT06126744 2026-04-15

PuMP

51 enrolled

Glioma

NCT06325683 2026-04-15

Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

Phase 2 Suspended

184 enrolled

Glioblastoma

NCT06638931 2026-04-15

ANTARES

BreastCNSEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther solid neoplasmSarcomaThoracic

28 enrolled

Urachal adenocarcinoma, Urachal cancer, Fibrolamellar hepatocellular carcinoma, Secretory breast carcinoma, Carcinoma, Ovarian Epithelial, Adrenal Gland Neoplasms, Anus Neoplasms, Biliary Tract Neoplasms, Carcinosarcoma, Carcinoma, Adenoid Cystic, Fallopian Tube Neoplasms, Fibrosarcoma, Gallbladder Neoplasms, Granulosa Cell Tumor, Hemangiosarcoma, Leiomyosarcoma, Mesothelioma, Neuroblastoma, Parathyroid Neoplasms, Penile Neoplasms, Sarcoma, Sarcoma, Kaposi, Osteosarcoma, Thyroid Neoplasms, Trophoblastic Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Hepatoblastoma, Endodermal Sinus Tumor, Neuroectodermal Tumors, Primitive, Cholangiocarcinoma, Sertoli-Leydig Cell Tumor, Neurofibrosarcoma, Hemangioblastoma, Neuroendocrine Tumors

NCT06641908 2026-04-15

Anti-GD2 ADC M3554 in Advanced Solid Tumors

52 enrolled

CNSSarcoma

Glioblastoma, Sarcoma

NCT06649058 2026-04-15

EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active

316 enrolled

Brain Neoplasms

NCT06666712 2026-04-15

TPT CED rHGG

6 enrolled

CNSLymphoid

Brain Neoplasms, Glioma, Lymphoma, Follicular

NCT06721689 2026-04-15

PEEL-224

Phase 1/2 Recruiting

59 enrolled

CNSSarcoma

Neuroblastoma, Recurrence, Rhabdomyosarcoma

NCT06995872 2026-04-15

Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Children and Young Adults With Relapsed/Refractory Neuroblastoma

34 enrolled

Phase 1/2 Not yet recruiting

Neuroblastoma

NCT07437963 2026-04-15

Testing the Addition of Iberdomide to Therapy in People With Neuroblastoma That Has Come Back, Not Responded to Treatment, or Gotten Worse

76 enrolled

Neuroblastoma, Ganglioneuroblastoma

NCT07530536 2026-04-15

rTMS for Postoperative Brain Tumor Patients

6 enrolled

Brain Neoplasms, Neurologic Manifestations

NCT00083135 2026-04-14

N2000-01: Double Infusion of Iodine I 131 Metaiodobenzylguanidine Followed by Autologous Stem Cell Transplantation

18 enrolled

Neuroblastoma

NCT00093353 2026-04-14

N2003-01: Irinotecan, Temozolomide, and Cefixime in Treating Young Patients With Recurrent or Resistant Neuroblastoma

Diarrhea, Neuroblastoma, Drug-Related Side Effects and Adverse Reactions

NCT00295919 2026-04-14

N2004-04: Fenretinide LXS in Treating Patients With Recurrent, Refractory, or Persistent Neuroblastoma

80 enrolled

Neuroblastoma

NCT00509353 2026-04-14

N2004-06: Irinotecan and Vincristine With 131I-MIBG Therapy for Resistant/Relapsed High-Risk Neuroblastoma

26 enrolled

Neuroblastoma

NCT00646230 2026-04-14

IV Fenretinide

17 enrolled

Phase 1/2 Active not recruiting

Neuroblastoma

NCT01362803 2026-04-14

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

99 enrolled 4 FDA

Neurofibromatosis 1, Pain, Neurofibroma, Plexiform

NCT01507506 2026-04-14

SPECTRO GLIO

Phase 3 Terminated

180 enrolled

Glioblastoma

NCT01872221 2026-04-14

STEMRI

Phase NA Completed

Glioblastoma

NCT01875601 2026-04-14

NK White Blood Cells and Interleukin in Children and Young Adults With Advanced Solid Tumors

16 enrolled

CNSSarcoma

Brain Neoplasms, Neuroblastoma, Sarcoma

NCT02390752 2026-04-14

Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...