Clinical Trials

Anemia, Aplastic, Anemia, Sickle Cell, Immunologic Deficiency Syndromes, Metabolic Diseases, Hematologic Neoplasms

NCT00001620 2026-05-29

Screening for Hematology Branch Protocols

Enrolling by invitation

10,000 enrolled

Phase 4 Not yet recruiting

Cytopenia, Anemia, Disease, Hematologic Diseases, Neutropenia, Thrombocytopenia, Hematologic Neoplasms

NCT07590648 2026-05-15

E-STOP2

136 enrolled

Classical hematologyLymphoidOther hematologic neoplasm

Neoplasms, Neutropenia, Hematologic Neoplasms, Febrile Neutropenia

NCT03670966 2026-05-04

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

Phase 1/2 Recruiting

30 enrolled

Anemia, Refractory, with Excess of Blasts, Leukemia, Lymphoid, Leukemia, Monocytic, Acute, Leukemia, Biphenotypic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT07277387 2026-04-23

Plasma Host-Microbe Proteomics to Predict Complications in High-risk Febrile Neutropenia

Not yet recruiting

350 enrolled

CNSClassical hematologyLymphoidOther hematologic neoplasm

Shock, Septic, Sepsis, Hematologic Neoplasms, Febrile Neutropenia

NCT05735717 2026-04-06

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Phase 2 Recruiting

70 enrolled

Chromosome 7, monosomy, Anemia, Refractory, with Excess of Blasts, Chromosome Aberrations, Influenza, Human, Neurofibromatosis 1, Leukemia, Myeloid, Acute, beta-Thalassemia, Neoplasm, Residual, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile

NCT05972577 2026-04-06

Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS Study

Classical hematologyLymphoidMyeloidOther hematologic neoplasmPlasma cell

30 enrolled

Anemia, Aplastic, Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Primary Myelofibrosis

NCT03431090 2026-04-03

Haploidentical Hematopoietic Cell Transplantation for Children With Hematologic Malignancies and Myelodysplasia

Phase 1/2 Active not recruiting

20 enrolled

Anemia, Refractory, with Excess of Blasts, Hematologic Neoplasms

NCT02958462 2026-02-23

Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

Phase NA Recruiting

2,000 enrolled

Classical hematologyLymphoidOther hematologic neoplasm

Bone Marrow Failure Disorders, Congenital Bone Marrow Failure Syndromes, Cytopenia, Neoplastic Syndromes, Hereditary, Hematologic Neoplasms

NCT01203722 2026-02-19

Reduced Intensity, Partially HLA Mismatched BMT to Treat Hematologic Malignancies

Phase 1/2 Completed

87 enrolled 24 charts

Anemia, Refractory, with Excess of Blasts, Lymphoma, Hematologic Neoplasms

NCT01199562 2026-01-28

Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant

Classical hematologyDermatologicLymphoidMyeloidOther hematologic neoplasmPlasma cell

153 enrolled

Pdgfra-Associated Chronic Eosinophilic Leukemia, Congenital Abnormalities, Immunoglobulin Light-chain Amyloidosis, Anemia, Aplastic, Blast Crisis, Burkitt Lymphoma, Cytomegalovirus Infections, Hodgkin Disease, Immunoblastic Lymphadenopathy, Leukemia, Hairy Cell, Leukemia, Mast-Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Multiple Myeloma, Mycosis Fungoides, Myeloproliferative Disorders, Polycythemia Vera, Sezary Syndrome, Thrombocythemia, Essential, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Biphenotypic, Acute, Leukemia, Prolymphocytic, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Neutrophilic, Chronic, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Hematologic Neoplasms, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis, Intraocular Lymphoma

NCT07270263 2025-12-26

HEM-DOAC

Phase NA Recruiting

100 enrolled

Classical hematologyLymphoidOther hematologic neoplasmPlasma cell

Leukemia, Lymphoma, Multiple Myeloma, Pulmonary Embolism, Hematologic Neoplasms, Venous Thromboembolism

NCT01881334 2025-11-20

Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants

Available

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

Adrenoleukodystrophy, Anemia, Aplastic, Anemia, Sickle Cell, Immunologic Deficiency Syndromes, Lymphoma, Metabolic Diseases, Myelodysplastic Syndromes, Thalassemia, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03320642 2025-10-21

GRAVITAS-119: Itacitinib in Combination With Calcineurin Inhibitor-Based Interventions for the Prophylaxis of Graft-Versus Host Disease

Phase 1 Terminated

84 enrolled

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

Anemia, Refractory, with Excess of Blasts, Graft vs Host Disease, Hodgkin Disease, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Hematologic Neoplasms, Lymphoma, Mantle-Cell

NCT06398457 2025-09-26

Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies

Phase EARLY_PHASE1 Recruiting

8 enrolled

Classical hematologyLymphoidMyeloidOther hematologic neoplasmPlasma cell

Anemia, Aplastic, Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Primary Myelofibrosis

NCT03399773 2025-08-26

Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes

Phase 2 Active not recruiting

31 enrolled

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

Anemia, Refractory, with Excess of Blasts, Myelodysplastic Syndromes, Leukemia, Biphenotypic, Acute, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01660347 2025-05-02

Donor Stem Cell Boost in Treating Patients With Low Blood Cells After Donor Stem Cell Transplant

Phase NA Withdrawn

Anemia, Lymphopenia, Neutropenia, Thrombocytopenia, Hematologic Neoplasms

NCT05053100 2025-05-02

Understanding the Risk of Blood Clots and Bleeding in Patients With Hematological Malignancies, HAT Study

Classical hematologyLymphoidMyeloidOther hematologic neoplasmPlasma cell

100 enrolled

Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myeloproliferative Disorders, Thrombocytopenia, Hematologic Neoplasms, Venous Thrombosis

NCT06455553 2025-02-13

VISCOTHEM-1

48 enrolled

Phase NA Not yet recruiting

Thrombocytopenia, Hematologic Neoplasms

NCT06794320 2025-01-27

Antibiotic Stewardship in Suspected Neutropenic Fever (ASTERIC Trial)

648 enrolled

Carcinoma, Emergencies, Neoplasms, Hematologic Neoplasms, Febrile Neutropenia

NCT06787326 2025-01-22

ONFIRE

228 enrolled

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

Toxemia, Hematologic Neoplasms, Febrile Neutropenia

NCT04083170 2025-01-01

Cord Blood Transplant With Dilanubicel for the Treatment of HIV Positive Hematologic Cancers

Phase 2 Terminated

1 enrolled 11 charts

Anemia, Refractory, Anemia, Refractory, with Excess of Blasts, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, HIV Infections, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT05396157 2024-11-27

Venous Thromboembolism in Hematologic Malignancy and Hematopoietic Cell Transplant Patients: a Retrospective Study

813 enrolled

Hemorrhage, Thrombocytopenia, Hematologic Neoplasms, Venous Thrombosis

NCT05298930 2024-08-21

EVAADE

Classical hematologyMyeloidOther hematologic neoplasm

15 enrolled

Anemia, Aplastic, Myelodysplastic Syndromes, Severe Combined Immunodeficiency, Hematologic Neoplasms

NCT04142372 2024-04-24

HemaTMA

Classical hematologyLymphoidMyeloidOther hematologic neoplasmPlasma cell

5,000 enrolled

Anemia, Refractory, with Excess of Blasts, Leukemia, Lymphoma, Myeloproliferative Disorders, Neoplasms, Hematologic Neoplasms, Neoplasms, Plasma Cell

NCT03878524 2024-03-04

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Phase 1 Terminated

2 enrolled

BreastClassical hematologyGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmPlasma cell

Anemia, Blast Crisis, Breast Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Thrombocytosis, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis

NCT06278896 2024-02-26

END

Phase 3 Not yet recruiting

260 enrolled

Classical hematologyOther hematologic neoplasmPlasma cell

Hematologic Neoplasms, Febrile Neutropenia

NCT06250595 2024-02-09

ENROL

Recruiting

37,090 enrolled

Bone Marrow Failure Disorders, Anemia, Anemia, Sickle Cell, Leukemia, Thalassemia, Iron Metabolism Disorders, Hematologic Neoplasms, Hemostatic Disorders, Neoplasms, Plasma Cell

NCT04439006 2023-12-26

Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization

Phase 1 Completed

10 enrolled

Classical hematologyMyeloidOther hematologic neoplasm

Anemia, Aplastic, Monoclonal Gammopathy of Undetermined Significance, Myelodysplastic Syndromes, Hematologic Neoplasms

NCT02065869 2023-09-29

Safety Study of Gene Modified Donor T-cells Following TCRαβ+ Depleted Stem Cell Transplant

Phase 1/2 Terminated

187 enrolled 8 charts

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

Primary Immunodeficiency Diseases, Cytopenia, Anemia, Anemia, Aplastic, Anemia, Sickle Cell, Fanconi Anemia, Hemoglobinopathies, Leukemia, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes, Osteopetrosis, Thalassemia, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Anemia, Diamond-Blackfan, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03733249 2023-09-26

Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study

Phase 1/2 Terminated

187 enrolled 8 charts

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

Primary Immunodeficiency Diseases, Cytopenia, Anemia, Anemia, Aplastic, Anemia, Sickle Cell, Fanconi Anemia, Hemoglobinopathies, Leukemia, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes, Thalassemia, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Anemia, Diamond-Blackfan, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03609840 2023-09-21

Study of Thiotepa and TEPA Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant Patients

25 enrolled

Anemia, Sickle Cell, Fanconi Anemia, Hemoglobinopathies, Immunologic Deficiency Syndromes, Thalassemia, Hematologic Neoplasms

NCT05061654 2023-08-14

CEF-10

Phase 4 Withdrawn

Hematologic Neoplasms, Febrile Neutropenia

NCT05038722 2023-07-13

Function of Platelets Used for Transfusions

Enrolling by invitation

240 enrolled

Classical hematologyMyeloidOther hematologic neoplasm

Thrombocytopenia, Hematologic Neoplasms

NCT04631211 2023-05-25

Thrombosomes® in Bleeding Thrombocytopenic Patients Study

Phase 2 Terminated

21 enrolled

Anemia, Aplastic, Myelodysplastic Syndromes, Myeloproliferative Disorders, Thrombocytopenia, Hematologic Neoplasms

NCT03801122 2023-05-06

TTRAP-Bleeding

Phase 2 Completed

18 enrolled

Hemorrhage, Thrombocytopenia, Hematologic Neoplasms

NCT05793073 2023-03-31

AMS Intervention for Early Adaptation of Empirical Antibiotic Therapy in High-risk Neutropenic Patients

55 enrolled

Classical hematologyLymphoidOther hematologic neoplasmPlasma cell

Neutropenia, Hematologic Neoplasms, Febrile Neutropenia

NCT05672420 2023-01-05

Umbilical Cord Derived Mesenchymal Stem Cells for Treatment-induced Myelosuppression in Hematologic Malignancies

Phase 1/2 Unknown

181 enrolled

Anemia, Hemorrhage, Infections, Leukemia, Lymphoma, Multiple Myeloma, Neutropenia, Thrombocytopenia, Hematologic Neoplasms

NCT02074436 2022-07-19

PROBLEMA

Phase 2 Terminated

29 enrolled 10 charts

Phase 1 Active not recruiting

Thrombocytopenia, Hematologic Neoplasms

NCT02477878 2022-07-12

Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant

10 enrolled

Classical hematologyLymphoidMyeloidOther hematologic neoplasmPlasma cell

Anemia, Refractory, with Excess of Blasts, Leukemia, Lymphoma, Multiple Myeloma, Myelodysplastic Syndromes, Hematologic Neoplasms

NCT03301168 2022-07-12

Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant

Phase 1/2 Active not recruiting

120 enrolled

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

Primary Immunodeficiency Diseases, Cytopenia, Anemia, Aplastic, Leukemia, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes, Osteopetrosis, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03087227 2022-05-09

NEUTROSIS

121 enrolled

Classical hematologyMyeloidOther hematologic neoplasm

Neutropenia, Hematologic Neoplasms, Febrile Neutropenia

NCT04331483 2022-02-28

EVAADE

Phase NA Withdrawn

Anemia, Aplastic, Myelodysplastic Syndromes, Severe Combined Immunodeficiency, Hematologic Neoplasms

NCT05203809 2022-01-24

THERMAL

Unknown

20 enrolled

Classical hematologyLymphoidOther hematologic neoplasmPlasma cell

Body Temperature Changes, Leukemia, Lymphoma, Hematologic Neoplasms, Neoplasms, Plasma Cell, Febrile Neutropenia

NCT01316549 2021-10-04

HCT

67 enrolled

Anemia, Sickle Cell, Fanconi Anemia, Hemoglobinopathies, Immunologic Deficiency Syndromes, Thalassemia, Hematologic Neoplasms

NCT03609814 2021-10-04

Study of Clofarabine and Fludarabine Drug Exposure in Pediatric Bone Marrow Transplantation (HCT)

30 enrolled

Anemia, Sickle Cell, Fanconi Anemia, Hemoglobinopathies, Immunologic Deficiency Syndromes, Thalassemia, Hematologic Neoplasms

NCT03609827 2021-10-04

Study of Melphalan Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant Patients

25 enrolled

Anemia, Sickle Cell, Fanconi Anemia, Hemoglobinopathies, Immunologic Deficiency Syndromes, Thalassemia, Hematologic Neoplasms

NCT02964325 2021-08-19

MIPLATE

Phase NA Terminated

422 enrolled 24 charts

Thrombocytopenia, Hematologic Neoplasms

NCT04892160 2021-05-19

Distracting Through Procedural Pain and Distress

67 enrolled