Announcements Trials
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Phase

Phase 2 1Phase 1/2 1

Status

Withdrawn 1Active not recruiting 1

Sponsor Class

OTHER 1NIH 1

Study Type

Interventional 2

Sponsor

Cancer Type

Myeloid 4Other hematologic neoplasm 2Classical hematology 2

Conditions

Myeloproliferative Disorders 2Anemia, Refractory, with Excess of Blasts 2Myelodysplastic-Myeloproliferative Diseases 1Myelodysplastic Syndromes 1Leukemia, Myelomonocytic, Chronic 1Cytopenia 1

Interventions

fludarabine phosphate 34Cyclophosphamide 34Peripheral Blood Stem Cell Transplantation 23Busulfan 22Mycophenolic Acid 21Cyclosporine 20Whole-Body Irradiation 19Tacrolimus 18Antilymphocyte Serum 18Melphalan 16Filgrastim 16Radiotherapy 15Methotrexate 14fludarabine 12Cord Blood Stem Cell Transplantation 12Methylprednisolone 10Cytarabine 10Etoposide 8sargramostim 6Granulocyte Colony-Stimulating Factor 5Cyclosporins 5Alemtuzumab 4thymoglobulin 3merphos 3Tretinoin 3Thiotepa 3Thalidomide 3Sirolimus 3Rituximab 3Leucovorin 3

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Myeloproliferative Disorders × decitabine and cedazuridine drug combination × Classical hematology × Clear all
NCT05600894 2026-05-13

Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm

National Cancer Institute (NCI)

Phase 2 Active not recruiting
132 enrolled
Classical hematologyMyeloidOther hematologic neoplasm

Anemia, Refractory, with Excess of Blasts, Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Myelomonocytic, Chronic, Myelodysplastic-Myeloproliferative Diseases

NCT06284460 2026-02-13

Phase I/II Study of a Combination of Decitabine and Cedazuridine (ASTX727) and ASTX029, an ERK Inhibitor, for Patients With RAS Pathway Mutant Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms

M.D. Anderson Cancer Center

Phase 1/2 Withdrawn
Classical hematologyMyeloid

Anemia, Refractory, with Excess of Blasts, Myeloproliferative Disorders

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