Clinical Trials

Brain Neoplasms, Melanoma

NCT03340129 2026-02-02

ABC-X

218 enrolled

Brain Neoplasms, Melanoma

NCT03873818 2026-01-09

Low Dose Ipilimumab With Pembrolizumab in Treating Patients With Melanoma That Has Spread to the Brain

24 enrolled 13 charts

Phase 2 Active not recruiting

Brain Neoplasms, Melanoma

NCT02910700 2025-12-17

Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma

52 enrolled

Phase 2 Active not recruiting

Brain Neoplasms, Melanoma

NCT02374242 2025-12-10

ABC

76 enrolled

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT04955743 2025-11-24

Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma

CNSDermatologicGenitourinary

18 enrolled

Brain Neoplasms, Carcinoma, Renal Cell, Melanoma

NCT06887088 2025-10-01

ENCEFALO

33 enrolled

Brain Neoplasms, Melanoma

NCT04511013 2025-09-11

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

112 enrolled

Brain Neoplasms, Melanoma

NCT06712927 2025-09-08

Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases

60 enrolled

Brain Neoplasms, Melanoma

NCT02681549 2025-08-07

Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer (NSCLC)

41 enrolled 20 charts

CNSDermatologicThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT03898908 2025-05-21

EBRAIN-MEL

48 enrolled 24 charts

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT02978404 2024-06-28

Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases

CNSDermatologicGenitourinaryThoracic

26 enrolled

Clear-cell metastatic renal cell carcinoma, Brain Neoplasms, Melanoma, Small Cell Lung Carcinoma

NCT02107755 2024-05-21

Stereotactic Radiation Therapy and Ipilimumab in Treating Patients With Metastatic Melanoma

8 enrolled 12 charts

Brain Neoplasms, Melanoma

NCT02621515 2024-05-06

CA209-322

7 enrolled

Brain Neoplasms, Melanoma

NCT00445965 2024-04-04

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

CNSDermatologicGynecologicOther solid neoplasmSarcomaThoracic

78 enrolled 11 charts

Familial ependymoma, Uveal Melanoma, Astrocytoma, Brain Neoplasms, Chondrosarcoma, Ependymoma, Glioblastoma, Glioma, Lung Neoplasms, Medulloblastoma, Melanoma, Neoplasm Metastasis, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Glioma, Subependymal, Gliosarcoma, Rhabdoid Tumor, Optic Nerve Glioma, Small Cell Lung Carcinoma, Desmoplastic Small Round Cell Tumor

NCT03430947 2023-09-14

RadioCoBRIM

20 enrolled

Brain Neoplasms, Melanoma

NCT04644315 2023-08-07

ALpha-T

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidNETSarcomaThoracic

1 enrolled 5 charts

Thyroid Cancer, Papillary, Brain Neoplasms, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Renal Cell, Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Melanoma, Neoplasms, Neoplasms by Site, Ovarian Neoplasms, Pancreatic Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Salivary Gland Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Lymphoma, Large-Cell, Anaplastic, Cholangiocarcinoma, Neuroendocrine Tumors

NCT03563729 2023-07-13

MEMBRAINS

80 enrolled

Brain Neoplasms, Melanoma

NCT00003308 2023-06-22

Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma

CNSDermatologicGenitourinaryGynecologicSarcoma

Brain Neoplasms, Carcinoma, Renal Cell, Chondrosarcoma, Kidney Neoplasms, Melanoma, Neoplasm Metastasis, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT03911869 2023-05-31

POLARIS

13 enrolled 55 charts

Brain Neoplasms, Melanoma

NCT02115139 2022-11-08

GRAY-B

58 enrolled 15 charts

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT04434560 2022-07-26

Neoadjuvant Immunotherapy in Brain Metastases

BreastCNSDermatologicGenitourinaryGynecologicThoracic

1 enrolled 7 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Melanoma, Ovarian Neoplasms, Triple Negative Breast Neoplasms

NCT02974803 2021-08-20

Concurrent Dabrafenib + Trametinib With Sterotactic Radiation in BRAF Mutation-Positive Malignant Melanoma and Brain Metastases

6 enrolled 3 charts

Brain Neoplasms, Melanoma

NCT02097732 2021-05-12

Ipilimumab Induction in Patients With Melanoma Brain Metastases Receiving Stereotactic Radiosurgery

4 enrolled 10 charts

Brain Neoplasms, Melanoma

NCT02085070 2021-03-24

MK-3475 in Melanoma and NSCLC Patients With Brain Metastases

65 enrolled 10 charts

CNSDermatologicThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT03728465 2021-02-03

Evaluation of Safety and Efficacy of Patients With Four and More Symptomatic Brain Metastases of Melanoma

6 enrolled

Brain Neoplasms, Melanoma

NCT02308020 2020-12-19

A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer, Non-small Cell Lung Cancer, or Melanoma That Has Spread to the Brain

BreastCNSDermatologicThoracic

162 enrolled 25 charts

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT02038218 2020-09-16

DM-CHOC-PEN

BreastCNSDermatologicThoracic

29 enrolled 9 charts

Brain Neoplasms, Breast Neoplasms, Glioblastoma, Lung Neoplasms, Melanoma

NCT02537600 2020-01-27

CONVERCE

43 enrolled

BreastCNSDermatologicThoracic

Brain Neoplasms, Melanoma

NCT04001725 2019-11-13

OPTIMAL

Phase 2 Unknown

110 enrolled

Brain Neoplasms, Breast Neoplasms, Diabetes Mellitus, Lung Neoplasms, Melanoma, Neoplasms

NCT02039947 2019-05-21

Study to Evaluate Treatment of Dabrafenib Plus Trametinib in Subjects With BRAF Mutation-Positive Melanoma That Has Metastasized to the Brain

127 enrolled 17 charts

Brain Neoplasms, Melanoma

NCT01978236 2018-08-17

Dabrafenib/Trametinib, BRAF or BRAF AND MEK Pre-op With BRAF and MEK Post-op, Phase IIB, Melanoma With Brain Mets,Biomarkers and Metabolites

6 enrolled 9 charts

Brain Neoplasms, Melanoma

NCT00068666 2016-12-15

Temozolomide and Radiation Therapy in Treating Patients With Stage IV Malignant Melanoma With Measurable and Unresectable Cancer of the Central Nervous System

41 enrolled

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT00587964 2016-02-22

Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicSarcomaThoracic

51 enrolled 6 charts

Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Sarcoma, Testicular Neoplasms

NCT02662725 2016-01-25

IPI+RTS

73 enrolled

Brain Neoplasms, Melanoma

NCT00462982 2015-12-30

Sunitinib in Treating Patients With Brain Metastases Caused by Kidney Cancer or Melanoma

CNSDermatologicGenitourinary

8 enrolled 6 charts

Brain Neoplasms, Carcinoma, Renal Cell, Kidney Neoplasms, Melanoma, Neoplasm Metastasis

NCT00121420 2014-05-09

Study of Motexafin Gadolinium With Whole Brain Radiation Therapy Followed by Stereotactic Radiosurgery Boost in the Treatment of Patients With Brain Metastases

BreastCNSDermatologicGenitourinaryThoracic

45 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Kidney Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT01266967 2014-05-08

Break MB

172 enrolled 23 charts

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmSarcomaThoracic

Brain Neoplasms, Melanoma

NCT00637637 2013-08-12

External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases

Phase 2 Unknown

60 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Thyroid Cancer, Papillary, Anus Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Burkitt Lymphoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Hodgkin Disease, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Mouth Neoplasms, Mycosis Fungoides, Nasopharyngeal Neoplasms, Neoplasms, Wilms Tumor, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Parathyroid Neoplasms, Penile Neoplasms, Pheochromocytoma, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Sezary Syndrome, Stomach Neoplasms, Tongue Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Endometrial Neoplasms, Lymphoma, Large-Cell, Anaplastic, Adenocarcinoma, Follicular, Adrenocortical Carcinoma, Esthesioneuroblastoma, Olfactory, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Histiocytoma, Malignant Fibrous, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Dendritic Cell Sarcoma, Interdigitating

NCT00003911 2013-01-31

S9903: Whole Brain Radiotherapy Followed By Stereotactic Radiosurgery for Limited Malignant Melanoma Brain Metastases

2 enrolled

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT00072163 2013-01-17

Temozolomide and Thalidomide in Treating Patients With Brain Metastases Secondary to Melanoma

50 enrolled