Clinical Trials

1 enrolled

BreastCNSDermatologicOther hematologic neoplasmThoracic

Uveal Melanoma, Brain Neoplasms, Melanoma

NCT04789668 2026-03-18

Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases

Phase 1/2 Terminated

8 enrolled 13 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Hematologic Neoplasms, Triple Negative Breast Neoplasms

NCT04955743 2025-11-24

Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma

CNSDermatologicGenitourinary

18 enrolled

Brain Neoplasms, Carcinoma, Renal Cell, Melanoma

NCT04543188 2025-10-23

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

65 enrolled 52 charts

CNSDermatologicThoracic

Brain Diseases, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasms, Central Nervous System Neoplasms

NCT05388877 2025-08-19

E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma

13 enrolled

Brain Neoplasms, Melanoma

NCT04941430 2025-08-12

7T MRI Scan for the Early Detection of Melanoma Brain Metastases

2 enrolled

Brain Neoplasms, Melanoma

NCT03698162 2025-08-05

Precise DCE-MRI in Diagnosing Participants With Recurrent High Grade Glioma or Melanoma Brain Metastases

15 enrolled

Brain Neoplasms, Melanoma

NCT05831995 2024-12-06

Safety and Effectiveness of ABM-168 in Adults with Advanced Solid Tumors.

CNSDermatologicGastrointestinalThoracic

12 enrolled

Brain Neoplasms, Glioblastoma, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Colorectal Neoplasms

NCT01217411 2024-11-19

RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

Phase 1/2 Terminated

5 enrolled 6 charts

BreastCNSDermatologicThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Breast Neoplasms, Male, Small Cell Lung Carcinoma

NCT02621515 2024-05-06

CA209-322

7 enrolled

Brain Neoplasms, Melanoma

NCT02700763 2024-05-06

[18F]Dabrafenib Molecular Imaging in Melanoma Brain Metastasis

1 enrolled

Brain Neoplasms, Melanoma

NCT04187872 2023-12-27

TORCH

CNSDermatologicGastrointestinalGenitourinaryGynecologicThoracic

10 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Stomach Neoplasms, Carcinoma, Merkel Cell, Small Cell Lung Carcinoma

NCT03430947 2023-09-14

RadioCoBRIM

20 enrolled

Brain Neoplasms, Melanoma

NCT04644315 2023-08-07

ALpha-T

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidNETSarcomaThoracic

1 enrolled 5 charts

Thyroid Cancer, Papillary, Brain Neoplasms, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Renal Cell, Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Melanoma, Neoplasms, Neoplasms by Site, Ovarian Neoplasms, Pancreatic Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Salivary Gland Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Lymphoma, Large-Cell, Anaplastic, Cholangiocarcinoma, Neuroendocrine Tumors

NCT03911869 2023-05-31

POLARIS

13 enrolled 55 charts

Brain Neoplasms, Melanoma

NCT04434560 2022-07-26

Neoadjuvant Immunotherapy in Brain Metastases

BreastCNSDermatologicGenitourinaryGynecologicThoracic

1 enrolled 7 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Melanoma, Ovarian Neoplasms, Triple Negative Breast Neoplasms

NCT03332589 2022-05-20

E6201 Plus Dabrafenib for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS)

4 enrolled 9 charts

Brain Neoplasms, Melanoma

NCT02974803 2021-08-20

Concurrent Dabrafenib + Trametinib With Sterotactic Radiation in BRAF Mutation-Positive Malignant Melanoma and Brain Metastases

6 enrolled 3 charts

Brain Neoplasms, Melanoma

NCT02097732 2021-05-12

Ipilimumab Induction in Patients With Melanoma Brain Metastases Receiving Stereotactic Radiosurgery

4 enrolled 10 charts

Brain Neoplasms, Melanoma

NCT03728465 2021-02-03

Evaluation of Safety and Efficacy of Patients With Four and More Symptomatic Brain Metastases of Melanoma

6 enrolled

Brain Neoplasms, Melanoma

NCT02005614 2019-07-01

A Pilot/Phase II Study of Gamma Knife Radiosurgery for Brain Metastases Using 3Tesla MRI and Rational Dose Selection

BreastCNSDermatologicGastrointestinalGenitourinarySarcomaThoracic

39 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Sarcoma, Colorectal Neoplasms

NCT02900248 2019-04-02

N1

Terminated

23 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckMyeloidOther hematologic neoplasmPlasma cellSarcomaThoracic

Anus Neoplasms, Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Multiple Myeloma, Myelodysplastic Syndromes, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Sarcoma, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Endometrial Neoplasms, Hematologic Neoplasms

NCT01978236 2018-08-17

Dabrafenib/Trametinib, BRAF or BRAF AND MEK Pre-op With BRAF and MEK Post-op, Phase IIB, Melanoma With Brain Mets,Biomarkers and Metabolites

6 enrolled 9 charts

Brain Neoplasms, Melanoma

NCT00068666 2016-12-15

Temozolomide and Radiation Therapy in Treating Patients With Stage IV Malignant Melanoma With Measurable and Unresectable Cancer of the Central Nervous System

41 enrolled

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT00121420 2014-05-09

Study of Motexafin Gadolinium With Whole Brain Radiation Therapy Followed by Stereotactic Radiosurgery Boost in the Treatment of Patients With Brain Metastases

BreastCNSDermatologicGenitourinaryThoracic

45 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Kidney Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT00937482 2013-03-08

Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer