Announcements Trials
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Phase

Phase 1/2 1Phase 1 1

Status

Recruiting 7Terminated 6Completed 5Active not recruiting 2

Sponsor Class

INDUSTRY 2

Study Type

Interventional 2

Sponsor

Cancer Type

Gastrointestinal 37Head & Neck 4Thoracic 2Dermatologic 2Breast 2Sarcoma 1Other solid neoplasm 1NET 1Gynecologic 1Genitourinary 1Endocrine 1CNS 1

Conditions

Melanoma 241Carcinoma, Non-Small-Cell Lung 56Carcinoma, Renal Cell 40Skin Neoplasms 39Uveal Melanoma 31Squamous Cell Carcinoma of Head and Neck 30Neoplasms 30Colorectal Neoplasms 27Sarcoma 25Neoplasm Metastasis 25Carcinoma, Merkel Cell 24Ovarian Neoplasms 23Lung Neoplasms 22Stomach Neoplasms 21Carcinoma, Basal Cell 21Breast Neoplasms 20Head and Neck Neoplasms 18Esophageal Neoplasms 16Uterine Cervical Neoplasms 15Pancreatic Neoplasms 15Carcinoma, Hepatocellular 15Lymphoma, T-Cell, Cutaneous 14Urinary Bladder Neoplasms 13Triple Negative Breast Neoplasms 13Prostatic Neoplasms 13Carcinoma, Transitional Cell 13Brain Neoplasms 13Thyroid Neoplasms 11Small Cell Lung Carcinoma 10Mycosis Fungoides 10

Interventions

obinutuzumab 1naptumomab estafenatox 1durvalumab 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Active not recruiting × Esophageal Squamous Cell Carcinoma × Dermatologic × Clear all
NCT04140500 2026-03-18

Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors

Hoffmann-La Roche

Phase 1/2 Active not recruiting
170 enrolled
DermatologicGastrointestinalThoracic

Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT03983954 2025-11-28

Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumor, Including a Cohort Expansion in Esophageal Cancer.

NeoTX Therapeutics Ltd.

Phase 1 Active not recruiting
120 enrolled
BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Mesothelioma, Ovarian Neoplasms, Prostatic Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

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