Clinical Trials

3,000 enrolled

Dysplastic Nevus Syndrome, Melanoma, Skin Neoplasms

NCT02906943 2026-06-05

OCTANE

BreastDermatologicGastrointestinalHead & NeckThoracic

10,000 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Unknown Primary, Urogenital Neoplasms, Colorectal Neoplasms

NCT03949153 2026-06-05

CRIRIN

Phase 1/2 Completed

19 enrolled

Melanoma

NCT04074096 2026-06-05

BEPCOME-MB

10 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT05136196 2026-06-05

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Phase 2 Recruiting

150 enrolled

DermatologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Melanoma, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05355701 2026-06-05

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

CNSDermatologicHead & NeckThoracic

267 enrolled

Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Thyroid Neoplasms

NCT05538130 2026-06-05

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

CNSDermatologicHead & NeckThoracic

124 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Neoplasms, Thyroid Neoplasms

NCT07005297 2026-06-05

Clinical Genetics Branch Eligibility Screening Survey

Not yet recruiting

1,000 enrolled

Classical hematologyDermatologicSarcoma

Cardiofaciocutaneous syndrome, Legius syndrome, Congenital Bone Marrow Failure Syndromes, Melanoma, Cutaneous Malignant, Chordoma, Fanconi Anemia, Melanoma, Neoplasms, Li-Fraumeni Syndrome, Pulmonary Blastoma, Costello Syndrome

NCT07328516 2026-06-05

Natural History Study of Early Life Exposures in Agriculture (ELEA)

Enrolling by invitation

64,277 enrolled

BreastDermatologicGastrointestinalGenitourinaryOther hematologic neoplasm

Breast Neoplasms, Leukemia, Melanoma, Prostatic Neoplasms, Colorectal Neoplasms

NCT07527325 2026-06-05

Fianlimab&Cemiplimab as TotalNeoadj The (TNT) ForMelanoma

Phase 2 Not yet recruiting

35 enrolled

Phase NA Not yet recruiting

Melanoma

NCT07621614 2026-06-05

A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information

51 enrolled

Phase EARLY_PHASE1 Recruiting

Melanoma

NCT07628634 2026-06-05

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

25 enrolled

CNSDermatologicGenitourinaryLymphoidSarcoma

Adenocarcinoma, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Endocrine Gland Neoplasms, Glioma, Leiomyosarcoma, Lymphoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Carcinoma, Ductal

NCT07628894 2026-06-05

Circadian-Optimized Light Therapy for the Treatment of Patients With Advanced Melanoma Receiving Tumor-Infiltrating Lymphocyte Therapy

Phase 1 Not yet recruiting

8 enrolled

Phase 1 Active not recruiting

Melanoma

NCT03132922 2026-06-04

MAGE-A4ᶜ¹º³²T for Multi-Tumor

71 enrolled 20 charts

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Adenocarcinoma, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Melanoma, Neoplasm Metastasis, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms, Sarcoma, Synovial, Liposarcoma, Myxoid

NCT04458259 2026-06-04

Study of PF-07265807 in Participants With Metastatic Solid Tumors.

Phase 1 Terminated

88 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicThoracic

Parkinson Disease 4, Autosomal Dominant Lewy Body, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Small Cell Lung Carcinoma

NCT04566393 2026-06-04

Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies

Available

CNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Glioblastoma, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT04598009 2026-06-04

Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma

Phase 2 Recruiting

25 enrolled

BreastDermatologicGenitourinaryGynecologicHead & NeckThoracic

Melanoma

NCT04895709 2026-06-04

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

Phase 1/2 Recruiting

1,109 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Melanoma, Ovarian Neoplasms, Triple Negative Breast Neoplasms

NCT04955743 2026-06-04

Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma

Phase 2 Terminated

18 enrolled 13 charts

CNSDermatologicGenitourinary

Brain Neoplasms, Carcinoma, Renal Cell, Melanoma

NCT06066138 2026-06-04

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

DermatologicGastrointestinalSarcomaThoracic

30 enrolled

Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular, Melanoma, Sarcoma, Alveolar Soft Part, Small Cell Lung Carcinoma

NCT06319196 2026-06-04

ClearMe

Phase 2 Recruiting

54 enrolled

Melanoma

NCT07237594 2026-06-04

REPLAY

4 enrolled

Melanoma

NCT07627698 2026-06-04

DUET-MEL

Phase 1/2 Recruiting

36 enrolled

Uveal Melanoma, Melanoma

NCT00923026 2026-06-03

Follow Up Protocol for Subjects Previously Enrolled on NCI Surgery Branch Studies

Enrolling by invitation

1,150 enrolled

DermatologicEndocrineNET

Adenocarcinoma, Carcinoma, Melanoma, Neuroendocrine Tumors

NCT01009177 2026-06-03

Effect of Bosentan in Patients With Metastatic Melanoma Treated With Dacarbazine (DTIC)

Phase 2 Completed

80 enrolled

Melanoma, Neoplasm Metastasis

NCT02465060 2026-06-03

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellThoracic

6,452 enrolled 1 FDA

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Glioma, Carcinoma, Hepatocellular, Lung Neoplasms, Lymphoma, Melanoma, Multiple Myeloma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Hematologic Neoplasms

NCT03958383 2026-06-03

IT-hu14.18-IL2 With Radiation, Nivolumab and Ipilimumab for Melanoma

Phase 1/2 Terminated

8 enrolled 12 charts

Phase 3 Active not recruiting

Melanoma

NCT05625399 2026-06-03

RELATIVITY-127

579 enrolled

DermatologicHead & NeckThoracic

Melanoma

NCT06897735 2026-06-03

EDDIS-a1

Phase 1 Terminated

4 enrolled

Lung Neoplasms, Melanoma, Mouth Neoplasms

NCT03771859 2026-06-02

A Study of Patients Receiving Adjuvant Nivolumab Therapy for Melanoma That Has Been Removed

Completed

152 enrolled

Phase 1/2 Active not recruiting

Melanoma

NCT04083599 2026-06-02

GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors

350 enrolled

DermatologicGastrointestinalHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Melanoma, Colorectal Neoplasms

NCT05334069 2026-06-02

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

BreastDermatologicGastrointestinalGenitourinaryHead & NeckLymphoidMyeloidOther hematologic neoplasmSarcomaThoracic

2,000 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Esophageal Neoplasms, Lung Neoplasms, Melanoma, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT06400550 2026-06-02

Identification of Metabolic Phenotypes Associated With Melanoma Metastasis

400 enrolled

Melanoma

NCT06984328 2026-06-02

Study of the Effectiveness and Safety of Acasunlimab Alone and With Pembrolizumab to Treat Advanced Melanoma of the Skin That Has Returned After Treatment With an Approved Checkpoint Inhibitor Therapy (ABBIL1TY MELANOMA-07)

1 enrolled

Phase 2 Not yet recruiting

Melanoma, Recurrence

NCT07619898 2026-06-02

PHOENIX-ECP

112 enrolled

Colitis, Hepatitis, Melanoma

NCT02332668 2026-06-01

MK-3475-051

Phase 1/2 Recruiting

370 enrolled

DermatologicLymphoid

Lymphoma, Melanoma

NCT03467516 2026-06-01

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Metastatic Uveal Melanoma

34 enrolled

Uveal Melanoma, Melanoma, Uveal Diseases, Uveal Neoplasms

NCT04168528 2026-06-01

Phase I/IIa Study of 68GaNOTA-Anti-MMR-VHH2 for PET/CT

Phase 1/2 Terminated

13 enrolled

BreastDermatologic

Breast Neoplasms, Melanoma

NCT05039801 2026-06-01

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

DermatologicGynecologicHead & NeckSarcoma

54 enrolled

Squamous Cell Carcinoma of Head and Neck, Chondrosarcoma, Melanoma, Ovarian Neoplasms, Endometrial Neoplasms

NCT05542342 2026-06-01

SITISVEAL

Phase 2 Completed

16 enrolled 14 charts

Melanoma

NCT05912244 2026-06-01

A Study of IO102/IO103, Nivolumab, and Relatlimab in People With Melanoma

43 enrolled

Melanoma

NCT07124000 2026-06-01

DP-04

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

100 enrolled

Adenocarcinoma, Anus Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Melanoma, Mouth Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Testicular Neoplasms, Thyroid Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms, Gastrointestinal Stromal Tumors, Small Cell Lung Carcinoma

NCT00937937 2026-05-29

Dinaciclib in Treating Patients With Stage IV Melanoma

72 enrolled 14 charts

Melanoma

NCT01134614 2026-05-29

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

245 enrolled 8 charts

Phase 3 Active not recruiting

Melanoma

NCT01274338 2026-05-29

Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery

1,673 enrolled 19 charts

Melanoma

NCT01708941 2026-05-29

Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

88 enrolled 14 charts

Melanoma

NCT02073123 2026-05-29

Study of IDO Inhibitor in Combination With Checkpoint Inhibitors for Adult Patients With Metastatic Melanoma

Phase 1/2 Completed

131 enrolled 23 charts

Melanoma

NCT02196181 2026-05-29

Testing Two Different Treatment Schedules of Dabrafenib and Trametinib for Skin Cancer Which Has Spread

280 enrolled

Phase 3 Active not recruiting

Melanoma

NCT02224781 2026-05-29

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

267 enrolled 8 charts