Clinical Trials

10 enrolled

Brain Neoplasms, Melanoma

NCT04899908 2026-03-19

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

BreastCNSDermatologicGastrointestinalThoracic

134 enrolled

Brain Neoplasms, Breast Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Colorectal Neoplasms

NCT02858869 2026-03-09

Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases

25 enrolled 14 charts

CNSDermatologicThoracic

Uveal Melanoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT01644591 2026-03-05

Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases

49 enrolled

Brain Neoplasms, Melanoma

NCT07112170 2026-03-05

CURB-Melanoma

Phase NA Recruiting

52 enrolled

Melanoma

NCT03340129 2026-02-02

ABC-X

Phase 2 Recruiting

218 enrolled

DermatologicGenitourinaryThoracic

Brain Neoplasms, Melanoma

NCT05830058 2026-01-05

Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

Phase 2 Recruiting

32 enrolled

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Melanoma

NCT05522660 2025-12-11

USZ-STRIKE

Phase 3 Recruiting

180 enrolled

DermatologicThoracic

Carcinoma, Non-Small-Cell Lung, Melanoma

NCT02713269 2025-10-30

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

60 enrolled

Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasms, Unknown Primary, Sarcoma, Spinal Cord Compression, Thyroid Neoplasms

NCT04572451 2025-08-01

Safety of SBRT With Anti-PD1 and Anti-IL-8 for the Treatment of Multiple Metastases in Advanced Solid Tumors and Melanoma

Phase 1 Recruiting

50 enrolled

Phase 1 Active not recruiting

Melanoma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site

NCT05341349 2025-07-30

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases

1 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryThoracic

Uveal Melanoma, Brain Neoplasms, Melanoma

NCT04588246 2025-06-06

Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

Phase 3 Terminated

19 enrolled 19 charts

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Small Cell Lung Carcinoma

NCT03898908 2025-05-21

EBRAIN-MEL

48 enrolled 24 charts

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT01703507 2025-05-16

Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma

17 enrolled 15 charts

Brain Neoplasms, Melanoma

NCT02145910 2025-05-02

Vemurafenib Combined With Whole Brain Radiation Therapy or Radiosurgery in Patients With BRAF Mutation-Positive Melanoma and Brain Metastases

Phase 1 Withdrawn

Brain Neoplasms, Melanoma

NCT01416831 2025-03-17

SBRT/IL-2

44 enrolled 12 charts

Melanoma

NCT04793737 2025-03-05

PROMMEL

Phase NA Recruiting

27 enrolled

Melanoma

NCT03167177 2025-02-21

QUILT-3.046: NANT Melanoma Vaccine: Combination Immunotherapy in Subjects With Melanoma Who Have Progressed On or After Chemotherapy and PD-1/PD-L1 Therapy

Phase 1/2 Withdrawn

BreastCNSDermatologicThoracic

Melanoma

NCT01217411 2024-11-19

RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

Phase 1/2 Terminated

5 enrolled 6 charts

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Breast Neoplasms, Male, Small Cell Lung Carcinoma

NCT05169957 2024-11-05

Hepatic Ablation of Melanoma Metastases to Enhance Immunotherapy Response, a Phase I Clinical Trial (HAMMER I)

2 enrolled

Phase NA Active not recruiting

Uveal Melanoma, Melanoma

NCT03075072 2024-10-23

Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial

196 enrolled

BreastCNSDermatologicGenitourinaryThoracic

Brain Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Kidney Neoplasms, Lung Neoplasms, Melanoma, Recurrence

NCT04498767 2024-08-26

OligoRARE

Phase NA Recruiting

200 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Urinary Bladder Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Melanoma, Pancreatic Neoplasms, Sarcoma, Skin Neoplasms, Stomach Neoplasms

NCT02978404 2024-06-28

Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases

CNSDermatologicGenitourinaryThoracic

26 enrolled

Clear-cell metastatic renal cell carcinoma, Brain Neoplasms, Melanoma, Small Cell Lung Carcinoma

NCT02107755 2024-05-21

Stereotactic Radiation Therapy and Ipilimumab in Treating Patients With Metastatic Melanoma

8 enrolled 12 charts

DermatologicGenitourinarySarcoma

Brain Neoplasms, Melanoma

NCT02527304 2024-03-06

Adaptive Staged Stereotactic Body Radiation Therapy in Treating Patients With Spinal Metastases That Cannot Be Removed by Surgery

Phase NA Completed

24 enrolled 13 charts

Carcinoma, Renal Cell, Melanoma, Sarcoma, Spinal Cord Compression

NCT03511391 2024-01-23

CHEERS

DermatologicGenitourinaryHead & NeckThoracic

99 enrolled

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Head and Neck Neoplasms, Melanoma

NCT02407171 2023-10-31

Evaluating the Combination of MK-3475 and Sterotactic Body Radiotherapy in Patients With Metastatic Melanoma or NSCLC

Phase 1/2 Completed

61 enrolled 14 charts

DermatologicThoracic

Lung Neoplasms, Melanoma

NCT00003308 2023-06-22

Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma

CNSDermatologicGenitourinaryGynecologicSarcoma

Brain Neoplasms, Carcinoma, Renal Cell, Chondrosarcoma, Kidney Neoplasms, Melanoma, Neoplasm Metastasis, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT02821182 2022-12-29

A Phase II Trial of Stereotactic Body Radiotherapy With Concurrent Anti-PD1 Treatment in Metastatic Melanoma.

20 enrolled

Melanoma

NCT02716948 2021-11-30

SRS and Nivolumab in Treating Patients With Newly Diagnosed Melanoma Metastases in the Brain or Spine

17 enrolled

Brain Neoplasms, Melanoma

NCT01497808 2021-08-10

RADVAX™: A STRATIFIED PHASE I/II DOSE ESCALATION TRIAL OF HYPOFRACTIONATED RADIOTHERAPY FOLLOWED BY IPILIMUMAB IN METASTATIC MELANOMA

Phase 1/2 Completed

22 enrolled 11 charts

Melanoma

NCT02097732 2021-05-12

Ipilimumab Induction in Patients With Melanoma Brain Metastases Receiving Stereotactic Radiosurgery

4 enrolled 10 charts

Brain Neoplasms, Melanoma

NCT04042506 2021-04-12

SBRT as a Vaccination for Metastatic Melanoma

Phase 2 Withdrawn

Melanoma

NCT01970527 2020-02-13

Phase II Trial of Stereotactic Body Radiotherapy Followed by Ipilimumab in Treating Patients With Stage IV Melanoma

23 enrolled 13 charts

BreastCNSDermatologicGastrointestinalGenitourinarySarcomaThoracic

Melanoma

NCT02005614 2019-07-01

A Pilot/Phase II Study of Gamma Knife Radiosurgery for Brain Metastases Using 3Tesla MRI and Rational Dose Selection

Phase NA Terminated

39 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Sarcoma, Colorectal Neoplasms

NCT01721603 2018-01-23

Dabrafenib and Trametinib With Radiosurgery in Melanoma Brain Mets

2 enrolled 7 charts

Melanoma

NCT02406183 2017-01-10

Trial of SBRT With Concurrent Ipilimumab in Metastatic Melanoma

13 enrolled

Melanoma, Radiation Injuries

NCT01950195 2016-11-15

SRS (Stereotactic Radiosurgery) Plus Ipilimumab

Phase 1 Terminated

4 enrolled

Melanoma, Neoplasm Metastasis

NCT01973608 2016-10-31

MSB0010445 and Stereotactic Body Radiation Therapy in Advanced Melanoma

12 enrolled 10 charts

Melanoma

NCT00587964 2016-02-22

Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicSarcomaThoracic

51 enrolled 6 charts

Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Sarcoma, Testicular Neoplasms

NCT02662725 2016-01-25

IPI+RTS

73 enrolled

Brain Neoplasms, Melanoma

NCT00003911 2013-01-31

S9903: Whole Brain Radiotherapy Followed By Stereotactic Radiosurgery for Limited Malignant Melanoma Brain Metastases

2 enrolled